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Title:
MONOCLONAL ANTIBODY OR ANTIBODY FRAGMENT AGAINST CANINE CD20
Document Type and Number:
WIPO Patent Application WO/2021/066134
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a monoclonal antibody against canine CD20, the antibody being superior in effect to conventional antibodies. Provided is a monoclonal antibody or an antibody fragment against canine CD20, the monoclonal antibody comprising: a heavy chain variable region that comprises the amino acid sequence represented by SEQ ID NO:1 or an amino acid sequence with deletion, substitution or addition of one to several amino acids in the amino acid sequence represented by SEQ ID NO:1; a light chain variable region that comprises the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence with deletion, substitution or addition of one to several amino acids in the amino acid sequence represented by SEQ ID NO:2; and a light chain constant region that comprises the amino acid sequence represented by SEQ ID NO:3 or an amino acid sequence with deletion, substitution or addition of one to several amino acids in the amino acid sequence represented by SEQ ID NO:3.

Inventors:
MIZUNO TAKUYA (JP)
Application Number:
PCT/JP2020/037514
Publication Date:
April 08, 2021
Filing Date:
October 02, 2020
Export Citation:
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Assignee:
NIPPON ZENYAKU KOGYO CO LTD (JP)
International Classes:
A61K39/395; A61P35/00; A61P35/02; A61P43/00; C07K16/28; C12N15/13; G01N33/53
Foreign References:
JP2019026625A2019-02-21
JP2014532649A2014-12-08
JP2016013104A2016-01-28
Other References:
RUE S. M. ET AL.: "Identification of a candidate therapeutic antibody for treatment of canine B- cell lymphoma", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 164, 2015, pages 148 - 159, XP029124750, DOI: 10.1016/j.vetimm.2015.02.004
MIZUNO TAKUYA, KATO YUKINARI, KANEKO MIKA K., SAKAI YUSUKE, SHIGA TOSHINORI, KATO MASAHIRO, TSUKUI TOSHIHIRO, TAKEMOTO HIROFUMI, T: "Generation of a canine anti-canine CD 20 antibody for canine lymphoma treatment", SCIENTIFIC REPORTS, vol. 10, 10 July 2020 (2020-07-10), pages 1 - 12, XP055811125, DOI: 10.1038/s41598-020-68470-9
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
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