Title:
MONOCLONAL ANTIBODY FOR SPECIFICALLY RECOGNIZING GLYPICAN-3, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/166876
Kind Code:
A1
Abstract:
Provided are an isolated monoclonal antibody specifically binding to glypican-3 (GPC3) with high affinity, a nucleic acid molecule encoding a GPC3 antibody, an expression vector, a host cell, a method for preparing a GPC3 antibody, and an immunoconjugate, chimeric antigen receptor, immunocompetent cell, multispecific molecule, and pharmaceutical composition comprising the GPC3 antibody. Further provided are a method for detecting GPC3, and a method for treating GPC3-related diseases comprising hepatocellular carcinoma.
Inventors:
YOU SHUMEI (CN)
HU YINGYING (CN)
YANG CUIQING (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
HU YINGYING (CN)
YANG CUIQING (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
Application Number:
PCT/CN2022/074950
Publication Date:
August 11, 2022
Filing Date:
January 29, 2022
Export Citation:
Assignee:
JIANGSU SIMCERE PHARM CO LTD (CN)
International Classes:
A61K39/395; C07K16/30; A61P35/00; C12N15/13
Foreign References:
CN111662385A | 2020-09-15 | |||
CN111925445A | 2020-11-13 | |||
CN104520331A | 2015-04-15 | |||
US20190367607A1 | 2019-12-05 |
Other References:
NAKANO KIYOTAKA; ISHIGURO TAKAHIRO; KONISHI HIROKO; TANAKA MEGUMI; SUGIMOTO MASAMICHI; SUGO IZUMI; IGAWA TOMOYUKI; TSUNODA HIROYUK: "Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization", ANTI-CANCER DRUGS, vol. 21, no. 10, 1 November 2010 (2010-11-01), US , pages 907 - 916, XP008177208, ISSN: 0959-4973, DOI: 10.1097/CAD.0b013e32833f5d68
JIANG JIA-HAO, FU-MOU SUN, YU HAN, YA WANG, CAI JIA-LING, MIN WANG, JUAN ZHANG: "Screening and characterization of human anti-GPC3 single chain Fv antibody fragment selected by phage display", ACTA PHARMACEUTICA SINICA, vol. 52, 31 December 2017 (2017-12-31), CN , pages 1877 - 1883, XP055943367, ISSN: 0513-4870, DOI: 10.16438/j.0513-4870.2017-0687
ZHANG YONGDONG, QIU DONGRI, LI RONGHUA, LIU YAWU, SHI SHUAINAN, WANG YULIANG: "Preparation of a monoclonal antibody against the carcinoembryonic antigen, glypican‑3", MOLECULAR MEDICINE REPORTS, vol. 19, no. 5, 13 March 2019 (2019-03-13), GR , pages 3989 - 3995, XP055791336, ISSN: 1791-2997, DOI: 10.3892/mmr.2019.10019
JIANG JIA-HAO, FU-MOU SUN, YU HAN, YA WANG, CAI JIA-LING, MIN WANG, JUAN ZHANG: "Screening and characterization of human anti-GPC3 single chain Fv antibody fragment selected by phage display", ACTA PHARMACEUTICA SINICA, vol. 52, 31 December 2017 (2017-12-31), CN , pages 1877 - 1883, XP055943367, ISSN: 0513-4870, DOI: 10.16438/j.0513-4870.2017-0687
ZHANG YONGDONG, QIU DONGRI, LI RONGHUA, LIU YAWU, SHI SHUAINAN, WANG YULIANG: "Preparation of a monoclonal antibody against the carcinoembryonic antigen, glypican‑3", MOLECULAR MEDICINE REPORTS, vol. 19, no. 5, 13 March 2019 (2019-03-13), GR , pages 3989 - 3995, XP055791336, ISSN: 1791-2997, DOI: 10.3892/mmr.2019.10019
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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