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Title:
MONOCLONAL ANTIBODY FOR SPECIFICALLY RECOGNIZING GLYPICAN-3, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/166876
Kind Code:
A1
Abstract:
Provided are an isolated monoclonal antibody specifically binding to glypican-3 (GPC3) with high affinity, a nucleic acid molecule encoding a GPC3 antibody, an expression vector, a host cell, a method for preparing a GPC3 antibody, and an immunoconjugate, chimeric antigen receptor, immunocompetent cell, multispecific molecule, and pharmaceutical composition comprising the GPC3 antibody. Further provided are a method for detecting GPC3, and a method for treating GPC3-related diseases comprising hepatocellular carcinoma.

Inventors:
YOU SHUMEI (CN)
HU YINGYING (CN)
YANG CUIQING (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
Application Number:
PCT/CN2022/074950
Publication Date:
August 11, 2022
Filing Date:
January 29, 2022
Export Citation:
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Assignee:
JIANGSU SIMCERE PHARM CO LTD (CN)
International Classes:
C07K16/30; A61K39/395; A61P35/00; C12N15/13
Foreign References:
CN111662385A2020-09-15
CN111925445A2020-11-13
CN104520331A2015-04-15
US20190367607A12019-12-05
Other References:
NAKANO KIYOTAKA; ISHIGURO TAKAHIRO; KONISHI HIROKO; TANAKA MEGUMI; SUGIMOTO MASAMICHI; SUGO IZUMI; IGAWA TOMOYUKI; TSUNODA HIROYUK: "Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization", ANTI-CANCER DRUGS, vol. 21, no. 10, 1 November 2010 (2010-11-01), US , pages 907 - 916, XP008177208, ISSN: 0959-4973, DOI: 10.1097/CAD.0b013e32833f5d68
JIANG JIA-HAO, FU-MOU SUN, YU HAN, YA WANG, CAI JIA-LING, MIN WANG, JUAN ZHANG: "Screening and characterization of human anti-GPC3 single chain Fv antibody fragment selected by phage display", ACTA PHARMACEUTICA SINICA, vol. 52, 31 December 2017 (2017-12-31), CN , pages 1877 - 1883, XP055943367, ISSN: 0513-4870, DOI: 10.16438/j.0513-4870.2017-0687
ZHANG YONGDONG, QIU DONGRI, LI RONGHUA, LIU YAWU, SHI SHUAINAN, WANG YULIANG: "Preparation of a monoclonal antibody against the carcinoembryonic antigen, glypican‑3", MOLECULAR MEDICINE REPORTS, vol. 19, no. 5, 13 March 2019 (2019-03-13), GR , pages 3989 - 3995, XP055791336, ISSN: 1791-2997, DOI: 10.3892/mmr.2019.10019
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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