Title:
MONOPHOSPHINE LIGAND BASED ON TETRAMETHYL SPIROBIINDANE SKELETON AND INTERMEDIATE THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/213987
Kind Code:
A1
Abstract:
Disclosed are a monophosphine ligand based on a tetramethyl spirobiindane skeleton and an intermediate thereof, and a preparation method therefor and the use thereof. The monophosphine ligand is a compound having the structure represented by the general formula I or I', or an enantiomer, a racemate or a diastereomer of the compound, and includes a phosphonite ligand, a phosphite ligand, a phosphoramidite ester ligand, phosphoric acid and phosphoramide. The monophosphine ligand is obtained by taking a known 3,3,3',3'-tetramethyl-1,1'-spirobiindane-7,7'-diformaldehyde derivative as a raw material via a preparation route in which a compound of the general formula II is used as a key intermediate. The present invention develops a novel monophosphine ligand, which can be used as a ligand in metal-catalyzed organic reactions or for directly catalyzing organic reactions, and in particular can be widely used as a chiral monophosphine ligand in many chiral catalytic reactions including asymmetric addition, asymmetric hydrogenation, asymmetric coupling, and asymmetric allyl alkylation, etc. and has economic practicability and industrial application prospects.
Inventors:
LIN XUFENG (CN)
SHAN HUANYU (CN)
ZHOU QIAOXIA (CN)
SHAN HUANYU (CN)
ZHOU QIAOXIA (CN)
Application Number:
PCT/CN2018/086893
Publication Date:
November 14, 2019
Filing Date:
May 15, 2018
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
B01J31/22; C07F9/6574; C07B53/00; C07C37/56; C07C39/17; C07C41/26; C07C303/40; C07D209/44; C07D291/08; C07F9/6571; C07F15/00
Foreign References:
| CN1887893A | 2007-01-03 | |||
| CN102516302A | 2012-06-27 | |||
| CN102030780A | 2011-04-27 | |||
| CN1439643A | 2003-09-03 |
Other References:
FANGXI XU: "Spinol-Derived Phosphoric Acids: Synthesis and Application in Enantioselective Friedel-Crafts Reaction of Indoles with Imines", J. ORG. CHEM., vol. 75, no. 24, 17 November 2010 (2010-11-17), pages 8677 - 8680, XP055651293
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO.,LTD. (CN)
Download PDF: