Title:
MONOSIALOGANGLIOSIDE-BASED NEUROPROTECTIVE AGENT OBTAINED FROM PORCINE BRAIN
Document Type and Number:
WIPO Patent Application WO/2018/020326
Kind Code:
A3
Abstract:
Method for isolating monosialotetrahexosylganglioside (GMl) involves preparing porcine brain extract, adding sodium hydroxide, separating, conducting adsorption and desorption of extract, stirring, transferring mixture, adding hydrochloric acid, separating, washing, drying, performing chromatographic separation, collecting fraction, concentrating, dissolving in e.g. trichloromethane, passing through resin column, concentrating, adding acetone, filtering, drying, diluting, adding activated carbon, stirring, re- filtering, concentrating, adding acetone, cooling and drying.
Inventors:
MANDROVSKIY VALERIY ALEXEEVICH (RU)
Application Number:
PCT/IB2017/001232
Publication Date:
April 26, 2018
Filing Date:
July 25, 2017
Export Citation:
Assignee:
LONG SHENG PHARMA LTD (CN)
International Classes:
C07H15/10; C07H1/08
Foreign References:
| CN102020684A | 2011-04-20 | |||
| CN101899074A | 2010-12-01 | |||
| CN104151372A | 2014-11-19 | |||
| CN85102590A | 1985-11-10 |
Other References:
LIN QIN ET AL.: "Studies on Determination of Monosialotetrahexosylganglioside Sodium Salt and Its Impurities", CHINESE JOURNAL OF PHARMACEUTICAL ANALYSIS, 31 December 2005 (2005-12-31), pages 153 - 156
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