MONOSUBSTITUTED OR POLYSUBSTITUTED AMPHIPHILIC HYPOCRELLIN DERIVATIVE, PREPARATION METHOD THEREFOR, AND USES THEREOF

WIPO Patent Application WO/2017/067497

A9

Disclosed are a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof. In the present invention, the amphiphilic hypocrellin derivative having substituted functional groups such as condensed ethylene glycol and quaternary ammonium salt shows in its absorption spectrum a substantial redshift and an enhanced molar extinction coefficient compared to hypocrellin precursor, and can highly effectively produce reactive oxygen species such as singlet state oxygen under light-sensitive conditions. By adjusting the hydrophobicity and hydrophilicity of said derivative, said derivative can have different amphiphilicity and enhanced biocompatibility with cells or tissues. The amphiphilic hypocrellin derivative can satisfy the requirements for different clinical medications and addresses the conflict between medicinal hydrophilicity and lipophilicity caused by different administration methods. Compared to the first and second generation commercial photosensitizer, under the same conditions, the amphiphilic hypocrellin derivative photosensitizer of the present invention has higher photodynamic capabilities in the eradication of live tumor cells.

WANG PENGFEI (CN)
WU JIASHENG (CN)
LIU WEIMIN (CN)
GU YING (CN)
GE JIECHAO (CN)
ZHENG XIULI (CN)
ZHANG HONGYAN (CN)

PCT/CN2016/102832

January 25, 2018

October 21, 2016

Click for automatic bibliography generation  

TECHNICAL INST OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (CN)

C07C221/00; A61K41/00; A61P35/00; C07C213/06; C07C217/12; C07C225/32; C07C249/02; C07C251/24; C07C319/18; C07C323/25

BEIJING JANLEA PATENT AGENCY CO., LTD. (CN)

View/Download PDF      PDF Help

Previous Patent: METHOD FOR ASSIGNING TIME-DOMAIN RESOURCES, BASE STATION AND USER EQUIPMENT

Next Patent: TILTING, FORWARD-SHIFTING, ROTATABLE PARKING EQUIPMENT