MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS

Title:

MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS

Document Type and Number:

WIPO Patent Application WO2004002491

Kind Code:

A8

Abstract:

The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

Inventors:

GRAUPE MICHAEL (US)
PALMER JAMES T (US)
PATTERSON JOHN W (US)
PICKETT STEPHEN D (GB)
ALDOUS DAVID J (US)
THURAIRATNAM SUKANTHINI (US)
TIMM ANDREAS P (US)
HALLEY FRANK (FR)
LAI JUSTINE (GB)
LINK JOHN (US)
LI JIAYAO (US)

Application Number:

PCT/US2003/019960

Publication Date:

February 17, 2005

Filing Date:

June 25, 2003

Export Citation:

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Assignee:

AVENTIS PHARMA INC (US)
AXYS PHARM INC (US)
GRAUPE MICHAEL (US)
PALMER JAMES T (US)
PATTERSON JOHN W (US)
PICKETT STEPHEN D (GB)
ALDOUS DAVID J (US)
THURAIRATNAM SUKANTHINI (US)
TIMM ANDREAS P (US)
HALLEY FRANK (FR)
LAI JUSTINE (GB)
LINK JOHN (US)
LI JIAYAO (US)

International Classes:

A61K31/4245; A61K31/5375; A61K31/5377; C07C317/44; C07C323/60; C07D205/08; C07D207/24; C07D213/40; C07D223/12; C07D263/32; C07D263/56; C07D271/06; C07D271/10; C07D277/26; C07D277/64; C07D285/08; C07D295/185; C07D413/04; C07D413/12; C07D498/04; (IPC1-7): A61K31/5375; C07D271/06; C07D263/56; C07D413/12; C07D498/04; C07D213/40; C07D295/185; A61K31/5377; A61K31/4245

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