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Patent Searching and Data


Title:
MOTILIDE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2001060833
Kind Code:
A3
Abstract:
The present invention provides novel macrolide compounds of the formulas (I, II, III or IV) wherein: R is hydroxyl or methoxy; R<1> is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR<9>, (a, b, c, and d) where R<9> is C1-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R<10> and R<11> are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl; R<2> and R<3> are each independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl, alkynylaryl or R<2> and R<3> together form a cycloalkyl or a cycloaryl moiety; R<4> is hydrogen or methyl; R<5> is hydrogen, hydroxyl, oxo, or together with R<6> and the carbons to which they are attached form a cyclic carbonate; R<6> is hydrogen, hydroxyl, OR<12> where R<12> is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R5 and the carbons to which they are attached form a cyclic carbonate; R7 is methyl, C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; R<8> is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; and, x is a single or a double bond.

Inventors:
ASHLEY GARY (US)
BURLINGAME MARK (US)
CARRERAS CHRISTOPHER (US)
SANTI DANIEL (US)
Application Number:
PCT/US2001/005218
Publication Date:
January 24, 2002
Filing Date:
February 15, 2001
Export Citation:
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Assignee:
KOSAN BIOSCIENCES INC (US)
ASHLEY GARY (US)
BURLINGAME MARK (US)
CARRERAS CHRISTOPHER (US)
SANTI DANIEL (US)
International Classes:
A61K31/7048; A61P1/00; A61P1/04; A61P1/10; A61P1/14; A61P1/16; A61P17/00; C07H17/08; (IPC1-7): C07H17/08; A61K31/70
Domestic Patent References:
WO1993013780A11993-07-22
Foreign References:
US5854407A1998-12-29
US4677097A1987-06-30
Other References:
See also references of EP 1255763A2
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