Title:
MOUSE MAIT-LIKE CELLS AND MOUSE RICH IN MAIT CELLS
Document Type and Number:
WIPO Patent Application WO/2021/085450
Kind Code:
A1
Abstract:
Provided is a MAIT-like cell enriched mouse. Also, provided are: a MAIT cell enriched mouse having introduced therein a MAIT-like cell obtained by inducing the differentiation of an artificial pluripotent stem cell derived by reprogramming of a mouse-derived MAIT cell; and a MAIT cell enriched mouse that is produced through a chimeric mouse using a MAIT cell-derived artificial pluripotent stem cell, and that has, in an allele, a TCR α chain gene or a TCR β chain gene for which gene rearrangement has been done in a MAIT cell-specific manner.
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Inventors:
WAKAO HIROSHI (JP)
SUGIMOTO CHIE (JP)
SUGIMOTO CHIE (JP)
Application Number:
PCT/JP2020/040361
Publication Date:
May 06, 2021
Filing Date:
October 28, 2020
Export Citation:
Assignee:
DOKKYO MEDICAL UNIV (JP)
International Classes:
A01K67/027; C12N5/0783; C12Q1/02
Domestic Patent References:
| WO2014069672A1 | 2014-05-08 |
Other References:
WAKAO, H. ET AL.: "Expansion of Functional Human Mucosal-Associated Invariant T Cells via Reprogramming to Pluripotency and Redifferentiation.", CELL STEM CELL, vol. 12, no. 5, pages 546 - 558, XP055243716, DOI: 10.1016/j.stem. 2013.03.00 1
WAKAO, HIROSHI ET AL.: "Emerging and Re-emerging Infectious Diseases IV. Special Lecture, Prevention and treatment for intractable infectious diseases through the iPS C-based technology : status quo and perspective", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 74, no. 12, 1 December 2016 (2016-12-01), pages 2064 - 2069
CHIBA ASAKO, CHIBA ASAKO, TAJIMA RYOHSUKE, TOMI CHIHARU, MIYAZAKI YUSEI, YAMAMURA TAKASHI, MIYAKE SACHIKO: "Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis", ARTHRITIS & RHEUMATISM, WILEY INTERSCIENCE, US, vol. 64, no. 1, 1 January 2012 (2012-01-01), US , pages 153 - 161, XP055932063, ISSN: 0004-3591, DOI: 10.1002/art.33314
NAKAO, H.: "Reprogramming of MAIT Cells to Pluripotency and Redifferentiation.", METHODS IN MOLECULAR BIOLOGY, vol. 2098, 3 December 2019 (2019-12-03), pages 237 - 257, XP055932061, DOI: 10.1007/978-1-0716-0207-2_16
WAKAO, HIROSHI ET AL.: "Emerging and Re-emerging Infectious Diseases IV. Special Lecture, Prevention and treatment for intractable infectious diseases through the iPS C-based technology : status quo and perspective", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 74, no. 12, 1 December 2016 (2016-12-01), pages 2064 - 2069
CHIBA ASAKO, CHIBA ASAKO, TAJIMA RYOHSUKE, TOMI CHIHARU, MIYAZAKI YUSEI, YAMAMURA TAKASHI, MIYAKE SACHIKO: "Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis", ARTHRITIS & RHEUMATISM, WILEY INTERSCIENCE, US, vol. 64, no. 1, 1 January 2012 (2012-01-01), US , pages 153 - 161, XP055932063, ISSN: 0004-3591, DOI: 10.1002/art.33314
NAKAO, H.: "Reprogramming of MAIT Cells to Pluripotency and Redifferentiation.", METHODS IN MOLECULAR BIOLOGY, vol. 2098, 3 December 2019 (2019-12-03), pages 237 - 257, XP055932061, DOI: 10.1007/978-1-0716-0207-2_16
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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