A MOUSE UNABLE TO EXPRESS FUNCTIONAL ALPHA-4 INTEGRIN PROTEIN, AND METHODS FOR ASSAYING COMPOUNDS OR AGENTS FOR ALPHA-4 INTEGRIN PROTEIN ANTAGONIST ACTIVITY AND A GENETIC MARKER FOR EVALUATING EFFICACY OF MODULATORS OF SIGNALING ACTIVITY OF A VLA-4 RECEPTOR

Title:

Document Type and Number:

WIPO Patent Application WO2002101017

Kind Code:

A3

Abstract:

Provided herein is a mouse that is unable to express functional alpha-4-integrin protein, and methods for assaying agents for alpha-4 integrin antagonist activity, as well as genetic markers for analyzing the efficacy of VLA-4 modulators, and particularly antagonists.

Inventors:

WASEL-NIELEN MONIKA (US)
KIRSCHBAUM BERNHARD (DE)
FOSTER MARTYN (GB)
POLITES GREGORY (US)
KHORKOVA OLGA (US)
ZHU BIN (US)

Application Number:

PCT/US2002/018477

Publication Date:

September 04, 2003

Filing Date:

June 07, 2002

Export Citation:

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Assignee:

AVENTIS PHARMA INC (US)
WASEL-NIELEN MONIKA (US)
KIRSCHBAUM BERNHARD (DE)
FOSTER MARTYN (GB)
POLITES GREGORY (US)
KHORKOVA OLGA (US)
ZHU BIN (US)

International Classes:

A01K67/027; C12N15/09; C12N15/85; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; C12R1/91; (IPC1-7): C07K14/00; A01K67/027; C12N15/00

Foreign References:

Other References:

LIU S. ET AL.: "alpha-4 Integrins in cardiovascular development and diseases", TRENDS IN CARDIOVASCULAR MEDICINE, vol. 10, no. 6, 2000, pages 253 - 257, XP002955786
PEREIRA S. ET AL.: "Resting murine, neutrophils express functional alpha-4 integrins that signal through src family kinases", THE JOURNAL OF IMMUNOLOGY, vol. 166, 2001, pages 4115 - 4123, XP002963969
See also references of EP 1406997A4

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