Title:
MRI CONTRAST AGENT FOR ARTERIOSCLEROSIS DETECTION
Document Type and Number:
WIPO Patent Application WO/2006/025304
Kind Code:
A1
Abstract:
An MRI contrast agent comprising a contrast unit containing an unpaired electron having atom and/or molecule and capable of raising or lowering any MRI signal and, linked thereto, a detection unit capable of selectively recognizing any arteriosclerosis region and binding to the region. For example, the chemical structure contained in the detection unit can be represented by the formula (I) wherein at least one of R1 to R11 is, for example, a sulfonate group, and X is, for example, a substituted or unsubstituted phenyl group.
More Like This:
| JPS6379647 | NMR APPARATUS |
Inventors:
KATAYAMA YOSHIKI (JP)
SHIMOKAWA HIROAKI (JP)
SHIMOKAWA HIROAKI (JP)
Application Number:
PCT/JP2005/015631
Publication Date:
March 09, 2006
Filing Date:
August 29, 2005
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
KATAYAMA YOSHIKI (JP)
SHIMOKAWA HIROAKI (JP)
KATAYAMA YOSHIKI (JP)
SHIMOKAWA HIROAKI (JP)
International Classes:
A61B5/055; A61K49/10; A61K51/02; C07C309/50; (IPC1-7): A61K49/10; A61B5/055; A61K51/02; C07C309/50
Domestic Patent References:
| WO2004075925A1 | 2004-09-10 | |||
| WO2000050042A1 | 2000-08-31 |
Other References:
YAMAMOTO T. ET AL: "First functionalized MRI contrast agen recognizing vascular lesions", ANAL.SCI., vol. 20, no. 1, January 2004 (2004-01-01), pages 5 - 7, XP002979741
IKUTA K. ET AL: "Kekkan Naihi Shogai Bui o Ninshiki suru Shinki Kinoka Zoeizai no Kaihatsu", THE CHEMICAL SOCIETY OF JAPAN, KOEN YOKOSHU, vol. 83, no. 2, 2003, pages 972 1-G3-46, XP002999515
YAMAMOTO T. ET AL: "Kekkan Naihi Shogai Sensing o Shiko shita Shinki MRI Zoeizai", THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY NENKAI KOEN YOSHISHU, vol. 52, 2003, pages 141, IG23, XP002999516
URASAKI T. ET AL: "Kekkan Naihi Shogai o Ninshiki suru Shinki MRI Zoeizai no Gosei to Hyoka", THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY NENKAI KOEN YOSHISHU, vol. 52, 18 August 2004 (2004-08-18), pages 141, J1018, XP002999517
YAMAMOTO T. ET AL: "In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent", BIOORG.MED.CHEM.LETT., vol. 14, no. 11, 2004, pages 2787 - 2790, XP004841288
IKUTA K. ET AL: "Kekkan Naihi Shogai Bui o Ninshiki suru Shinki Kinoka Zoeizai no Kaihatsu", THE CHEMICAL SOCIETY OF JAPAN, KOEN YOKOSHU, vol. 83, no. 2, 2003, pages 972 1-G3-46, XP002999515
YAMAMOTO T. ET AL: "Kekkan Naihi Shogai Sensing o Shiko shita Shinki MRI Zoeizai", THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY NENKAI KOEN YOSHISHU, vol. 52, 2003, pages 141, IG23, XP002999516
URASAKI T. ET AL: "Kekkan Naihi Shogai o Ninshiki suru Shinki MRI Zoeizai no Gosei to Hyoka", THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY NENKAI KOEN YOSHISHU, vol. 52, 18 August 2004 (2004-08-18), pages 141, J1018, XP002999517
YAMAMOTO T. ET AL: "In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent", BIOORG.MED.CHEM.LETT., vol. 14, no. 11, 2004, pages 2787 - 2790, XP004841288
Attorney, Agent or Firm:
Tsutsui, Satoru (3-30-15 Hakataekimae, Hakata-ku, Fukuoka-sh, Fukuoka 11, JP)
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