Title:
MUCIN PRODUCTION INHIBITOR
Document Type and Number:
WIPO Patent Application WO2005041858
Kind Code:
A3
Abstract:
A drug which inhibits the excess production of mucin in the respiratory tract epithelium to ameliorate the function of the respiratory tract and is hence useful in the prevention of or treatments for respiratory diseases accompanied by the excess secretion of mucus. The mucin production inhibitor comprises as an active ingredient either a benzimidazole derivative represented by the following formula (1): (wherein A represents a triazole group; R<1> and R<2> are the same or different and each represents an aliphatic hydrocarbon group optionally having an alicyclic hydrocarbon group or represents an alicyclic hydrocarbon group; R<3> represents hydrogen or a substituent; and R<4> represents hydrogen or a protective group for the nitrogen atom) or a pharmaceutically acceptable salt of the derivative.
Inventors:
SASAKI EIJI (JP)
KITEI MAMORU (JP)
KITEI MAMORU (JP)
Application Number:
PCT/JP2004/015634
Publication Date:
August 11, 2005
Filing Date:
October 21, 2004
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
SASAKI EIJI (JP)
KITEI MAMORU (JP)
SASAKI EIJI (JP)
KITEI MAMORU (JP)
International Classes:
A61K31/4196; A61P11/00; A61P11/10; A61P11/12; A61P29/00; A61P31/06; A61P43/00; C07D403/04; A61K; (IPC1-7): A61K31/4196; A61P11/00; A61P11/10; A61P11/12; A61P29/00; A61P31/06; A61P43/00
Domestic Patent References:
| WO1999024425A1 | 1999-05-20 |
Foreign References:
| JP2002338493A | 2002-11-27 |
Other References:
ASAKA T ET AL: "Shinki PDE4 Sentakuteki Sogaizai TAS-303 no Mucin Sansei Oyobi Kido Johi no Haisaibo ni Taisuru Sayo.", JAPANESE JOURNAL OF ALLERGOLOGY., vol. 52, no. 8/9, 2003, pages 934, XP002996090
OMORI K ET AL: "Shinki phosphodiesterase (PDE) 4 Sentakuteki Sogaiyaku TAS-203 no Koensho Sayo.", JAPANESE JOURNAL OF ALLERGOLOGY., vol. 52, no. 8/9, 2003, pages 934, XP002996091
TAMAKI J.: "COPD ni Okeru Kido Kabunpitsu no Mechanism-Chiryo Senryaku eno Feedback.", vol. 57, no. 10, 2002, pages 2373 - 2379, XP002996092
TAMAKI J.: "Tokushu 2 Mansei Kokyuki Shikkan to Kido Bunpitsu no Kiso to Rinsho 2. Kiso 1)Kido Bunpitsu no Mechanism.", MEDICINE AND DRUG JOURNAL., vol. 38, no. 12, 2002, pages 121 - 126, XP002996093
NOGAMI Y ET AL: "Tokushu 2 Mansei Kokyuki Shikkan to Kido Bunpitsu no Kiso to Rinsho 2. Kiso 2) Kido Bunpitsu no Topics-Mucin Idenshi to sono Hatsugen Chosetsu ni Tsuite.", MEDICINE AND DRUG JOURNAL., vol. 38, no. 12, 2002, pages 127 - 132, XP002996094
MATSU H.: "Tokushu 2 Mansei Kokyuki Shikkan to Kido Bunpitsu no Kiso to Rinsho 2. Kiso 2) Kiso 3) Kido Bunpitsueki ni yoru Kansen Bogyo Kiko to sono Hatan.", MEDICINE AND DRUG JOURNAL., vol. 38, no. 12, 2002, pages 133 - 138, XP002996095
OMORI K ET AL: "Shinki phosphodiesterase (PDE) 4 Sentakuteki Sogaiyaku TAS-203 no Koensho Sayo.", JAPANESE JOURNAL OF ALLERGOLOGY., vol. 52, no. 8/9, 2003, pages 934, XP002996091
TAMAKI J.: "COPD ni Okeru Kido Kabunpitsu no Mechanism-Chiryo Senryaku eno Feedback.", vol. 57, no. 10, 2002, pages 2373 - 2379, XP002996092
TAMAKI J.: "Tokushu 2 Mansei Kokyuki Shikkan to Kido Bunpitsu no Kiso to Rinsho 2. Kiso 1)Kido Bunpitsu no Mechanism.", MEDICINE AND DRUG JOURNAL., vol. 38, no. 12, 2002, pages 121 - 126, XP002996093
NOGAMI Y ET AL: "Tokushu 2 Mansei Kokyuki Shikkan to Kido Bunpitsu no Kiso to Rinsho 2. Kiso 2) Kido Bunpitsu no Topics-Mucin Idenshi to sono Hatsugen Chosetsu ni Tsuite.", MEDICINE AND DRUG JOURNAL., vol. 38, no. 12, 2002, pages 127 - 132, XP002996094
MATSU H.: "Tokushu 2 Mansei Kokyuki Shikkan to Kido Bunpitsu no Kiso to Rinsho 2. Kiso 2) Kiso 3) Kido Bunpitsueki ni yoru Kansen Bogyo Kiko to sono Hatan.", MEDICINE AND DRUG JOURNAL., vol. 38, no. 12, 2002, pages 133 - 138, XP002996095
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