MULTI-ORGAN MODEL - UNIV YONSEI IACF

Title:

MULTI-ORGAN MODEL

Document Type and Number:

WIPO Patent Application WO/2022/265352

Kind Code:

A1

Abstract:

The present invention relates to a multi-organ model. The multi-organ model of the present invention allows excellent cultures of organoids of each organ through hydrogel properties and the connection state of organoids of each organ and enables a more accurate reflection of a microenvironment and the interaction between organs in the body. In addition, the addition of free fatty acid treatment enables the phenotype of nonalcoholic fatty liver to be more accurately imitated so that the effect of candidate drugs on peripheral organs can also be analyzed.

Inventors:

CHO SEUNG WOO (KR)
CUI BAOFANG (KR)
KIM SU KYEOM (KR)
KIM SU RAN (KR)
BAE JUNG HO (KR)

Application Number:

PCT/KR2022/008401

Publication Date:

December 22, 2022

Filing Date:

June 14, 2022

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV YONSEI IACF (KR)

International Classes:

C12N5/071; C12M1/00; C12M3/00; C12M3/06; C12N5/077; G01N33/50

Foreign References:

KR20190143830A	2019-12-31
KR20200115343A	2020-10-07
US20150253309A1	2015-09-10
KR20200124449A	2020-11-03

Other References:

BAUER SOPHIE, WENNBERG HULDT CHARLOTTE, KANEBRATT KAJSA P., DURIEUX ISABELL, GUNNE DANIELA, ANDERSSON SHALINI, EWART LORNA, HAYNES: "Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model", SCIENTIFIC REPORTS, vol. 7, no. 1, XP093016123, DOI: 10.1038/s41598-017-14815-w