Title:
"MULTI-TARGET" COMPOUNDS WITH INHIBITORY ACTIVITY TOWARDS HISTONE DEACETYLASES AND TUBULIN POLYMERISATION, FOR USE IN THE TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2017/118822
Kind Code:
A3
Abstract:
The present invention relates to the design of new molecules, referred to as "multi-target" molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDAC) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the "multi-target" molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one "multi-target" molecule, and the use of such compositions in the treatment of cancer.
Inventors:
ALAMI MOUÂD (FR)
HAMZE ABDALLAH (FR)
BRION JEAN-DANIEL (FR)
BIGNON JÉRÔME (FR)
DUBOIS JOËLLE (FR)
HAMZE ABDALLAH (FR)
BRION JEAN-DANIEL (FR)
BIGNON JÉRÔME (FR)
DUBOIS JOËLLE (FR)
Application Number:
PCT/FR2017/050032
Publication Date:
November 23, 2017
Filing Date:
January 05, 2017
Export Citation:
Assignee:
UNIV PARIS-SUD (FR)
CENTRE NATIONAL DE LA RECHERCHE SCIENT (CNRS) (FR)
CENTRE NATIONAL DE LA RECHERCHE SCIENT (CNRS) (FR)
International Classes:
C07C259/06; A61K31/16; A61K31/165; A61K31/403; A61K31/404; A61K31/44; A61K31/47; A61K31/517; A61K45/06; C07C235/38; C07C235/64; C07C259/10; C07D209/42; C07D209/86; C07D213/65; C07D213/81; C07D215/14; C07D239/74; A61P35/00
Domestic Patent References:
| WO2008122620A1 | 2008-10-16 | |||
| WO2013026942A1 | 2013-02-28 |
Other References:
XUAN ZHANG ET AL: "The discovery of colchicine-SAHA hybrids as a new class of antitumor agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 11, 31 March 2013 (2013-03-31), GB, pages 3240 - 3244, XP055300402, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2013.03.049
XUAN ZHANG ET AL: "Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY., vol. 95, 18 March 2015 (2015-03-18), FR, pages 127 - 135, XP055300400, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2015.03.035
MAHAL KATHARINA ET AL: "Biological evaluation of 4,5-diarylimidazoles with hydroxamic acid appendages as novel dual mode anticancer agents", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER VERLAG, BERLIN, vol. 75, no. 4, 25 January 2015 (2015-01-25), pages 691 - 700, XP035472840, ISSN: 0344-5704, [retrieved on 20150125], DOI: 10.1007/S00280-015-2685-Z
MAHAPATRA DEBARSHI KAR ET AL: "Anti-cancer chalcones: Structural and molecular target perspectives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 98, 14 May 2015 (2015-05-14), pages 69 - 114, XP029163227, ISSN: 0223-5234, DOI: 10.1016/J.EJMECH.2015.05.004
XUAN ZHANG ET AL: "Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY., vol. 95, 18 March 2015 (2015-03-18), FR, pages 127 - 135, XP055300400, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2015.03.035
MAHAL KATHARINA ET AL: "Biological evaluation of 4,5-diarylimidazoles with hydroxamic acid appendages as novel dual mode anticancer agents", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER VERLAG, BERLIN, vol. 75, no. 4, 25 January 2015 (2015-01-25), pages 691 - 700, XP035472840, ISSN: 0344-5704, [retrieved on 20150125], DOI: 10.1007/S00280-015-2685-Z
MAHAPATRA DEBARSHI KAR ET AL: "Anti-cancer chalcones: Structural and molecular target perspectives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 98, 14 May 2015 (2015-05-14), pages 69 - 114, XP029163227, ISSN: 0223-5234, DOI: 10.1016/J.EJMECH.2015.05.004
Attorney, Agent or Firm:
REGIMBEAU (FR)
Download PDF:
Previous Patent: SINGLE-MODE MICROWAVE APPLICATOR, DEVICE AND METHOD FOR THERMAL TREATMENT OF PRODUCTS
Next Patent: STRETCHER TROLLEY
Next Patent: STRETCHER TROLLEY