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Patent Searching and Data


Title:
MULTIBINDING INHIBITORS OF CYCLOOXYGENASE-2
Document Type and Number:
WIPO Patent Application WO1999063939
Kind Code:
A3
Abstract:
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment of inflammation, pain, fever and the like.

Inventors:
JUDICE J KEVIN (US)
HIGGINS DEBORAH L (US)
GRIFFIN JOHN H (US)
Application Number:
PCT/US1999/012895
Publication Date:
February 10, 2000
Filing Date:
June 07, 1999
Export Citation:
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Assignee:
ADVANCED MEDICINE INC (US)
JUDICE J KEVIN (US)
HIGGINS DEBORAH L (US)
GRIFFIN JOHN H (US)
International Classes:
C07D231/12; A61K31/00; A61K31/341; A61K31/40; A61K31/415; A61K47/48; A61P29/00; A61P43/00; C07C233/36; C07C233/78; C07C237/24; C07C271/20; C07C321/04; C07C323/12; C07C335/08; C07C335/32; C07D207/333; C07D211/58; C07D215/56; C07D233/90; C07D235/30; C07D307/58; C07D401/06; C07D401/12; C07D401/14; C07D405/04; C07D413/14; C07D471/04; C07D471/14; C07D473/00; C07D473/34; C07D475/04; C07D475/08; C07D487/04; C07D487/06; C07D493/04; C07D493/06; C07D498/04; C07D519/00; C07H19/20; C12Q1/26; C12Q1/44; C12Q1/48; C12Q1/533; C40B20/06; C40B30/04; C40B40/04; C40B50/08; G01N33/573; G01N33/68; G01N33/92; C07B61/00; C07D207/32; (IPC1-7): A61K31/21; A61K31/165; A61K38/00; A61K39/00; A61K39/44; A61K39/395; A61K51/00; C07C69/74; C07C203/04; C07C235/44; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566
Domestic Patent References:
WO1997016405A11997-05-09
WO1992005802A11992-04-16
WO1997021445A11997-06-19
Foreign References:
US5559103A1996-09-24
GB2319032A1998-05-13
US5783698A1998-07-21
Other References:
KHANNA ET AL: "1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2", J. MED. CHEM.,, vol. 40, no. 11, 23 May 1997 (1997-05-23), pages 1619 - 1633
KHANNA ET AL: "1,2-Diarylimidazoles as Potent Cyclooxygenase-2 Selective and Orally Active Antiinflammatory Agents", J. MED. CHEM.,, vol. 40, no. 11, 23 May 1997 (1997-05-23), pages 1634 - 1647
STEWART ET AL: "Discovery of a New Cyclooxygenase-2 Lead Compound through 3-D Database Searching and Combinatorial Chemistry", BIOORG. MED. CHEM. LETT.,, vol. 8, 3 March 1998 (1998-03-03), pages 529 - 534
LIANG ET AL: "Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library", SCIENCE, vol. 274, 29 December 1996 (1996-12-29), pages 1520 - 1522
SHUKER ET AL: "Discovering High-Affinity Ligands for Proteins: SAR by NMR", SCIENCE, vol. 274, 29 December 1996 (1996-12-29), pages 1531 - 1534
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