Title:
MULTIBINDING INHIBITORS OF TOPOISOMERASE
Document Type and Number:
WIPO Patent Application WO1999064054
Kind Code:
A9
Abstract:
Disclosed are multibinding compounds which inhibit topoisomerases which are essential enzymes in higher encaryotes for DNA replication and repair. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligant is capable of binding to a topoisomerase and the distance between ligands is between about 2-50 ANGSTROM . The multibinding compounds of this invention are useful in the treatment and prevention of cancer, microbial infections and the like.
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Inventors:
LINSELL MARTIN S (US)
MEIER-DAVIS SUSAN (US)
GRIFFIN JOHN H (US)
MEIER-DAVIS SUSAN (US)
GRIFFIN JOHN H (US)
Application Number:
PCT/US1999/012908
Publication Date:
March 02, 2000
Filing Date:
June 08, 1999
Export Citation:
Assignee:
ADVANCED MEDICINE INC (US)
LINSELL MARTIN S (US)
MEIER DAVIS SUSAN (US)
GRIFFIN JOHN H (US)
LINSELL MARTIN S (US)
MEIER DAVIS SUSAN (US)
GRIFFIN JOHN H (US)
International Classes:
C07D499/44; A01N57/34; A61K31/00; A61K31/357; A61K31/397; A61K31/407; A61K31/421; A61K31/424; A61K31/431; A61K31/439; A61K31/444; A61K31/4545; A61K31/496; A61K31/522; A61K31/536; A61K31/5377; A61K31/546; A61K31/551; A61K31/65; A61K31/7028; A61K31/7034; A61K31/7036; A61K31/7042; A61K31/7048; A61K31/7052; A61K31/7056; A61K31/7064; A61K31/7068; A61K31/7072; A61K38/00; A61K39/00; A61K39/395; A61K39/44; A61K47/48; A61K51/00; A61P31/04; A61P31/18; A61P43/00; C07C233/36; C07C233/78; C07C237/24; C07C237/26; C07C271/20; C07C275/42; C07C321/04; C07C323/12; C07C335/08; C07C335/32; C07D207/333; C07D211/58; C07D215/56; C07D233/90; C07D235/30; C07D263/28; C07D265/18; C07D401/06; C07D401/12; C07D401/14; C07D405/04; C07D413/14; C07D453/02; C07D471/04; C07D471/14; C07D473/00; C07D473/34; C07D475/04; C07D475/08; C07D477/00; C07D487/04; C07D487/06; C07D493/04; C07D493/06; C07D495/04; C07D498/04; C07D498/18; C07D501/20; C07D519/00; C07H15/236; C07H15/238; C07H15/26; C07H17/08; C07H19/06; C07H19/20; C07K2/00; C07K4/00; C12N9/99; C12P19/38; C12Q1/26; C12Q1/44; C12Q1/48; C12Q1/533; C40B30/04; C40B40/04; G01N33/15; G01N33/50; G01N33/53; G01N33/543; G01N33/566; G01N33/573; G01N33/68; G01N33/92; G01N37/00; C07B61/00; C07D207/32; (IPC1-7): A61K38/00; A61K39/00; A61K39/44; A61K39/395; A61K51/00; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566; C07G11/00
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