Title:
MULTIPLE MODIFIED DERIVATIVES OF GELATIN AND CROSSLINKED MATERIAL THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/083542
Kind Code:
A1
Abstract:
A kind of multiply modified derivatives of gelatin having not only the structure
of formula (I) but also one of structures of formula (II), (III), and (IV) as well.
In the formulas, G refers to gelatin residue comprising A type, B type and the type
of gene restructuring; R1 refers to alkylene, or a linkage group with amide; R2
refers to alkyl, or aryl; R3 refers to alkylene; R4 refers to carboxyl or carboxylate.
The multiple modifying ways of gelatin comprise the modifying way of hydrophobic
activating the amide of branch amine group of gelatin, the modifying way of carboxylating
the amide of branch amine group of gelatin, the modifying way of thiolating the
branch carboxyl group of gelatin, and the modifying way of thiolating the modified
product of carboxylating the amide of branch amine group of gelatin. The multiply
modified derivatives of gelatin have versatile chemical structures and multi-functions.
The multiply modified derivatives of gelatin linked with crosslinking agent
can provide crosslinked gelatin material. The crosslinked gelatin material
can be used for matrix of bacterial growth.
Inventors:
SONG CHAN (CN)
Application Number:
PCT/CN2007/002863
Publication Date:
July 17, 2008
Filing Date:
September 29, 2007
Export Citation:
Assignee:
BIOREGEN BIOMEDICAL SHANGHAI C (CN)
SONG CHAN (CN)
SONG CHAN (CN)
International Classes:
C09H5/00; C08H1/06; C09J189/00; A61K8/98; A61K9/40
Foreign References:
| EP0576911A2 | 1994-01-05 | |||
| JP2002053599A | 2002-02-19 | |||
| EP0576912A2 | 1994-01-05 | |||
| US6509039B1 | 2003-01-21 | |||
| JPH01144477A | 1989-06-06 | |||
| JPH0196200A | 1989-04-14 | |||
| US4055554A | 1977-10-25 | |||
| CN1162971A | 1997-10-22 |
Other References:
LOU X. ET AL.: "Preparation and Characterization of Thiolated Chitosan and Gelatin", CHEMISTRY, no. 6, June 2006 (2006-06-01), pages 452 - 457, XP008133467
DU M. ET AL.: "Modified Gelatin Emulsion", FOOD SCIENCE, no. 11, November 1993 (1993-11-01), pages 47 - 50, XP008138034
See also references of EP 2103662A4
OLSEN ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 55, 2003, pages 1547
KUIJPERS ET AL., JOURNAL OF BIOMATERIALS SCIENCE: POLYMER EDITION, vol. 11, 2000, pages 225
MA ET AL.: "disclosed a hydrophobically poly-latic acid modified gelatin derivative with amphipathic properties", JOURNAL OF BIOMATERIALS SCIENCE: POLYMER EDITION, vol. 13, 2002, pages 67
VAN DEN BULCKE ET AL.: "disclosed methylacrylamide modified gelatin derivative", BIOMACROMOLECULES, vol. 1, 2000, pages 31
MORIKAWA; MATSUDA ET AL.: "disclosed a N-isopropylacrylamide grafted gelatin derivative with temperature-responsive gelation property", JOURNAL OF BIOMATERIALS SCIENCE: POLYMER EDITION, vol. 13, 2002, pages 167
SHU ET AL., BIOMATERIALS, vol. 24, 2003, pages 3825
SHU ET AL., BIOMACROMOLECULES, vol. 3, 2002, pages 1304
DU M. ET AL.: "Modified Gelatin Emulsion", FOOD SCIENCE, no. 11, November 1993 (1993-11-01), pages 47 - 50, XP008138034
See also references of EP 2103662A4
OLSEN ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 55, 2003, pages 1547
KUIJPERS ET AL., JOURNAL OF BIOMATERIALS SCIENCE: POLYMER EDITION, vol. 11, 2000, pages 225
MA ET AL.: "disclosed a hydrophobically poly-latic acid modified gelatin derivative with amphipathic properties", JOURNAL OF BIOMATERIALS SCIENCE: POLYMER EDITION, vol. 13, 2002, pages 67
VAN DEN BULCKE ET AL.: "disclosed methylacrylamide modified gelatin derivative", BIOMACROMOLECULES, vol. 1, 2000, pages 31
MORIKAWA; MATSUDA ET AL.: "disclosed a N-isopropylacrylamide grafted gelatin derivative with temperature-responsive gelation property", JOURNAL OF BIOMATERIALS SCIENCE: POLYMER EDITION, vol. 13, 2002, pages 167
SHU ET AL., BIOMATERIALS, vol. 24, 2003, pages 3825
SHU ET AL., BIOMACROMOLECULES, vol. 3, 2002, pages 1304
Attorney, Agent or Firm:
DING & ASSOCIATES PATENT TRADEMARK & LAW (Zhang Jiang High-Tech ZonePu Dong, Shanghai 3, CN)
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