Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
MUTANT IDH2 INHIBITOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/057975
Kind Code:
A1
Abstract:
A compound (as shown in formula I) as a mutant isocitrate dehydrogenase 2 (IDH2) inhibitor, and a preparation method and a pharmaceutical composition thereof. Also disclosed is a use of the compound or pharmaceutical composition thereof in treatment of mutant IDH2-mediated diseases. The IDH2 inhibitor can inhibit generation of 2-HG in cells carrying the most common IDH2 mutant, and is an ideal target with low toxicity for efficient targeting of anti-tumor drugs.

Inventors:
XU XIAOFENG (CN)
WANG CHAO (CN)
MA TENG (CN)
RONG HONGFEI (CN)
DING LIEMING (CN)
WANG JIABING (CN)
Application Number:
PCT/CN2020/118127
Publication Date:
April 01, 2021
Filing Date:
September 27, 2020
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
BETTA PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D239/50; A61K31/53; A61P35/00; C07D401/04; C07D401/14; C07D403/12
Domestic Patent References:
WO2018014852A12018-01-25
WO2016177347A12016-11-10
WO2013102431A12013-07-11
Foreign References:
CN110051673A2019-07-26
CN110054614A2019-07-26
JPH11158073A1999-06-15
Download PDF: