Title:
MUTANT IDH2 INHIBITOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/057975
Kind Code:
A1
Abstract:
A compound (as shown in formula I) as a mutant isocitrate dehydrogenase 2 (IDH2) inhibitor, and a preparation method and a pharmaceutical composition thereof. Also disclosed is a use of the compound or pharmaceutical composition thereof in treatment of mutant IDH2-mediated diseases. The IDH2 inhibitor can inhibit generation of 2-HG in cells carrying the most common IDH2 mutant, and is an ideal target with low toxicity for efficient targeting of anti-tumor drugs.
Inventors:
XU XIAOFENG (CN)
WANG CHAO (CN)
MA TENG (CN)
RONG HONGFEI (CN)
DING LIEMING (CN)
WANG JIABING (CN)
WANG CHAO (CN)
MA TENG (CN)
RONG HONGFEI (CN)
DING LIEMING (CN)
WANG JIABING (CN)
Application Number:
PCT/CN2020/118127
Publication Date:
April 01, 2021
Filing Date:
September 27, 2020
Export Citation:
Assignee:
BETTA PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D239/50; A61K31/53; A61P35/00; C07D401/04; C07D401/14; C07D403/12
Domestic Patent References:
WO2018014852A1 | 2018-01-25 | |||
WO2016177347A1 | 2016-11-10 | |||
WO2013102431A1 | 2013-07-11 |
Foreign References:
CN110051673A | 2019-07-26 | |||
CN110054614A | 2019-07-26 | |||
JPH11158073A | 1999-06-15 |
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