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Title:
MUTATED GLUCOSE DEHYDROGENASE
Document Type and Number:
WIPO Patent Application WO/2005/103248
Kind Code:
A1
Abstract:
By substituting the amino acid residue(s) at the 472- and/or 475-positions of a glucose dehydrogenase having the amino acid sequence represented by SEQ ID NO:13 by other amino acid residue(s), the substrate specificity of this enzyme for glucose is improved.

Inventors:
YAMAOKA HIDEAKI (JP)
Application Number:
PCT/JP2005/007687
Publication Date:
November 03, 2005
Filing Date:
April 22, 2005
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Assignee:
ARKRAY INC (JP)
YAMAOKA HIDEAKI (JP)
International Classes:
C12N1/21; C12N9/04; C12N15/09; C12Q1/32; (IPC1-7): C12N15/09; C12N1/21; C12N9/04; C12Q1/32
Domestic Patent References:
WO2003091430A12003-11-06
Foreign References:
JP2000312588A2000-11-14
Other References:
SODE K. ET AL: "improved substrate specificity and dynamic range for glucose measurement of Escherichia coli PQQ glucose dehydrogenase by site directed mutagenesis.", BIOTECHNOL LETT., vol. 19, no. 11, 1997, pages 1073 - 1077, XP000992302
See also references of EP 1739174A4
Attorney, Agent or Firm:
Kawaguchi, Yoshiyuki (4-10 Higashi Nihonbashi 3-chom, Chuo-ku Tokyo, JP)
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