Title:
MYCOSPORINE-LIKE AMINO ACIDS PORPHYRA-334 AND SHINORINE AND METHOD FOR EXTRACTING PORPHYRA-334 AND SHINORINE FROM SEAWEEDS
Document Type and Number:
WIPO Patent Application WO/2021/114218
Kind Code:
A1
Abstract:
Provided are mycosporine-like amino acids Porphyra-334 and Shinorine and a method for extracting Porphyra-334 and Shinorine from seaweeds. The method comprises the following steps: leaching, flocculating, filtering, performing chromatography, and concentrating Porphyra-334 and Shinorine. A Porphyra-334 crystal having a purity of at least 97% and a Shinorine crystal having a purity of at least 95% can be obtained through the above-mentioned method. The method can be used to effectively remove impurities in the seaweeds, so that the yield thereof is 20-30% higher than that of a traditional ion exchange resin and the process wastewater is less, and therefore, the method can be used for large-scale industrial production. The whole process is carried out continuously and conveniently, and the operation time is fast.
Inventors:
LE ZHANXIAN (CN)
Application Number:
PCT/CN2019/125103
Publication Date:
June 17, 2021
Filing Date:
December 13, 2019
Export Citation:
Assignee:
LE ZHANXIAN (CN)
International Classes:
A61K8/97; A61K36/02; A61K36/04; A61P17/18; C07C249/02
Foreign References:
| CN102740869A | 2012-10-17 | |||
| CN1473822A | 2004-02-11 | |||
| JP4973975B2 | 2012-07-11 | |||
| CN108484438A | 2018-09-04 | |||
| CN104887615A | 2015-09-09 | |||
| CN104495754B | 2016-06-29 | |||
| CN101489527A | 2009-07-22 | |||
| FR2803201B1 | 2004-11-26 |
Other References:
JIN NINGNING: "Study on the Isolation, Purification and Application of Mycosporine-like Amino Acids (maas) in Gracilaria Changii", CHINA MASTER’S THESES FULL-TEXT DATABASE, 1 June 2012 (2012-06-01), XP055820827
VOLKMANN MARC, GORBUSHINA ANNA A.: "A broadly applicable method for extraction and characterization of mycosporines and mycosporine-like amino acids of terrestrial, marine and freshwater origin", FEMS MICROBIOLOGY LETTERS, NO LONGER PUBLISHED BY ELSEVIER, vol. 255, no. 2, 1 February 2006 (2006-02-01), pages 286 - 295, XP055820833, ISSN: 0378-1097, DOI: 10.1111/j.1574-6968.2006.00088.x
VOLKMANN MARC, GORBUSHINA ANNA A.: "A broadly applicable method for extraction and characterization of mycosporines and mycosporine-like amino acids of terrestrial, marine and freshwater origin", FEMS MICROBIOLOGY LETTERS, NO LONGER PUBLISHED BY ELSEVIER, vol. 255, no. 2, 1 February 2006 (2006-02-01), pages 286 - 295, XP055820833, ISSN: 0378-1097, DOI: 10.1111/j.1574-6968.2006.00088.x
Attorney, Agent or Firm:
FUZHOU GEMHOPE PATENT AGENCY (CN)
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