Title:
(N-ALKYLCARBAMOYL) METHYL ENULOSIDES AND RELATED PYRANOSIDE CONTAINING AN ALFA, BETA, GAMA, DELTA - UNSATURATED ESTER, THEIR PREPARATION AND THEIR EFFICACY AS ANTIBACTERIAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2012/095793
Kind Code:
A3
Abstract:
The present invention comprises compounds of formula (I) and (II), embodying a 3-enopyranoside-2-ulose system and compound of formula (III), presenting a pyranoside α,β,γ,δ-unsaturated ester skeleton, derived from compound of formula (IV); processes for their preparation and their use as antibacterial agents.
Inventors:
GRASES SANTOS SILVA RAUTER AMELIA PILAR (PT)
RIBEIRO MARTINS XAVIER NUNO MANUEL (PT)
GUERRA JUSTINO JORGE ALBERTO (PT)
GOMES DE SOUSA NEVES ANA MARIA (PT)
PATRICIO GOULART DE MEDEIROS MARGARIDA ALEXANDRA (PT)
QUENEAU YVES (FR)
RIBEIRO MARTINS XAVIER NUNO MANUEL (PT)
GUERRA JUSTINO JORGE ALBERTO (PT)
GOMES DE SOUSA NEVES ANA MARIA (PT)
PATRICIO GOULART DE MEDEIROS MARGARIDA ALEXANDRA (PT)
QUENEAU YVES (FR)
Application Number:
PCT/IB2012/050125
Publication Date:
May 23, 2013
Filing Date:
January 10, 2012
Export Citation:
Assignee:
UNIV LISBOA (PT)
INST POLITECNICO DE SANTAREM ESCOLA SUPERIOR AGRARIA (PT)
GRASES SANTOS SILVA RAUTER AMELIA PILAR (PT)
RIBEIRO MARTINS XAVIER NUNO MANUEL (PT)
GUERRA JUSTINO JORGE ALBERTO (PT)
GOMES DE SOUSA NEVES ANA MARIA (PT)
PATRICIO GOULART DE MEDEIROS MARGARIDA ALEXANDRA (PT)
QUENEAU YVES (FR)
INST POLITECNICO DE SANTAREM ESCOLA SUPERIOR AGRARIA (PT)
GRASES SANTOS SILVA RAUTER AMELIA PILAR (PT)
RIBEIRO MARTINS XAVIER NUNO MANUEL (PT)
GUERRA JUSTINO JORGE ALBERTO (PT)
GOMES DE SOUSA NEVES ANA MARIA (PT)
PATRICIO GOULART DE MEDEIROS MARGARIDA ALEXANDRA (PT)
QUENEAU YVES (FR)
International Classes:
C07D309/32; A61K31/351; A61K31/7028; A61P31/04; C07H15/04
Foreign References:
| PT105476A | 2012-07-11 |
Other References:
NUNO M. XAVIER ET AL: "Synthesis of sugars embodying conjugated carbonyl systems and related triazole derivatives from carboxymethyl glycoside lactones. Evaluation of their antimicrobial activity and toxicity", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 2, 2 December 2010 (2010-12-02), pages 926 - 938, XP055056049, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2010.11.060
TIN Y C ET AL: "Solid Phase Synthesis of Peptidoglycan Monomers for the Generation of a Combinatorial Library", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 37, no. 45, 4 November 1996 (1996-11-04), pages 8097 - 8100, XP004031054, ISSN: 0040-4039, DOI: 10.1016/0040-4039(96)01849-7
TIN Y C ET AL: "Solid Phase Synthesis of Peptidoglycan Monomers for the Generation of a Combinatorial Library", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 37, no. 45, 4 November 1996 (1996-11-04), pages 8097 - 8100, XP004031054, ISSN: 0040-4039, DOI: 10.1016/0040-4039(96)01849-7
Attorney, Agent or Firm:
VIEIRA PEREIRA FERREIRA, Maria Silvina (Modet & Co.Rua Castilh, 50-9º -163 Lisboa, PT)
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