N-[(AMINOSULFONYL)PHENYL]-2-(1 ,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)- HYDRAZINECARBOTHIOAMIDE DERIVATIVES FOR TREATING CANCER AND IMMUNOLOGICAL DISORDERS

SPECIFICATION

TECHNICAL FIELD

The present invention relates to 1 -substituted 1 H-indole-2,3-dione derivatives shown by Formula II and 1 H-indole-2,3-dione 3-thiosemi carbazone derivative compounds having sulphamoil residue shown by Formula II I for being use as medicine, and the synthesis methods of these compounds.

PRIOR ART One of the most basic objects of medicine development studies is to develop and synthesize the compounds to selectively act on the enzyme and receptor systems seen as an important target in treatment of diseases like atherosclerotic vascular disease, diabetes, gout, Alzheimer since said systems play a critical role in pathogenesis of pluralities of inflammatory diseases and cancer, viral and bacterial infections. The success of their treatments and minimization of the side effects of the medicines will become possible by developing medicines which selectively target the target cell, enzyme or receptors without damaging healthy cells.

In general, chemotherapy medicines lead to death by creating DNA damage and cell stress. Therefore, it is difficult to find medicines having nano-molar binding affinity and which are specific to the target. The success of the cancer treatment and minimization the side effects of the chemotherapy are possible for developing selective medicines to the enzyme or receptor mechanisms. This approach will increase the susceptibility of the tumor cells to the chemotherapeutic medicines, and thus, at lower doses, this will provide obtaining anti-tumor effect. By means of this, the side effects of the chemotherapeutic medicines will also become possible.

1 H-indole-2,3-dione (isatin) is a versatile molecule having a wide spectrum. When the literature is observed, the anti-cancer, anti-viral and anti-inflammatory activity attracts attention. Particularly, it has been detected that the halogenated isatin derivatives show anticancer activity. Mannich bases of the 5-Bromo-3-o-nitrophenyl isatin hydrazone and 5- bromo-(2-oxo-3-indolinil) tiyazolidin-2,4-dione series are found to be effective against Walker carcinoma-256 and P388 lymphatic leukemia in mice. 5,7-dibromoisatin has shown cyto-toxic effect against U937 cells (human monocyte-like histiocytic lymphoma) and the N-benzyl derivatives of this molecule have shown cyto-toxic effect against metastatic breast adenocarcinoma cells (MDA-MB-231 ) and against various cancer cells. 5-Fluoro-3- substituted-2-indolinon derivative SU1 1248 (Sunitinib) has been approved by FDA in year 2006 for the treatment of gastro-intestinal-stromal tumors and advanced renal cell

SU 1 1248

(Sunitinib)

Angiogenesis is a substantially attractive target in cancer treatment. SU5416 (Semaxanib), which is tyrosine kinase inhibitor, is a potential inhibitor of VEGF (vascular endothelial growth factor) which plays an important role in angiogenesis. Pre-clinical studies have shown that the tumor growth after SU5416 treatment is inhibited and that the vascular concentration is reduced (O'Donnell et al, 2005). 3-substituted-2-indolinon compound SU9516, which is another tyrosine kinase inhibitor, selectively inhibits cdk2 (cyclin dependent kinase) and it pr Lane et al, 2001 ).

SU5416 SU9516

(Semaxanib)

One of the tyrosine kinases which play role in tumor formation is the c-Met kinase. In order to inhibit c-Met kinase signal path until now, various therapeutic strategies have been tried. Liang et al, (201 1 ) have synthesized various isatin derivative hydrazides starting from this point of view. It has been observed that since there are halogen in 5-position and hydrophobic substituents in position N1 , the inhibitor activity is increased. D25 molecule is

.

The isatin derivative anti-viral compound (I) rhino-virus effectively inhibits 3C protease. The proteases of SARS corona-virus (SARS CoV 3CL ^pro ) leading to rhino-virus and Severe Acute Respiratory Syndrome (SARS) are in sistein protease class and their active parts show structural similarity. Starting from this point of view, isatin derivative protease inhibitors (II

The structure-activity relation studies in isatin derivatives have shown that the substituents, attracting electron in position 5 of the indole ring, and the N-benzyl derivatives and the electron attracting groups which are substituted to the orthogonal para positions of the N- benzyl derivatives have increased activity against tumor cells. It has been found that 5,7- dibromo-N-(p-methyl-benzyl)isatin, which is the most effective derivative among a series compound synthesized within this scope, inhibits the metabolic activity of U937 and Jurkat cancer cells (Vine et al, 2007).

In another study, it has been detected that the N-phenethyl, N-pheneacyl, N-(1 - naphtyl)methyl and N-(2-naphtyl)methyl derivatives of 5,7-dibromoisatin show cyto-toxic effect in U937, Jurkat and MDA-MB-231 cells. It has been detected that the most efficient derivative in the test results is N-(1 -naphtyl)methyl derivative. These derivatives act by deteriorating the micro-tubule dynamics of the cells, for instance like vinblastine which is a chemotherapeutic agent (Matesic et al, 2008). The study made by Matheus et al (2007) has shown that isatin and its derivatives inhibit cyclooxygenase-2 (COX-2) related to inflammatory response in macrophage cells and the nitric oxide-synthase which can be induced, and depending on this, the study has shown that the PGE ₂ and NO levels in these cells are reduced. Since COX-2 and iNOS enzyme levels in inflamed and cancer cells substantially increase, this has shown that the isatin derivatives which inhibit these enzymes can be used both as anti-carcinogenase and as anti- inflammatory.

On the other hand, the anti-viral activities of 1 -Alkyl-1 H-indole-2,3-dione3-thiosemi- carbazone derivatives have been known for a long time. 1 -Methyl-1 H-indole-2,3-dione 3- thiosemicarbazone (methisazone) has been the first anti-viral agent used as prophylactic in pox disease (Heiner et al, 1971 ). 1 -Methyl-1 H-indole-2,3-dione 3-(N,N-diethylthio- semicarbazone) and 1 -allyl-1 7-indole-2,3-dione 3-(N,N-diallylthiosemicarbazone) compounds are effective against HIV as reverse-transcriptase inhibitors (Teitz et al, 1994).

It has been recorded that 1 -Alkyl-7-alkyl/halo-substituted 1 H-indole-2,3-dione 3-(N-aralkylthio semicarbazone) derivatives are New Delhi metallo-lactamase (NDM-1 ) inhibitors (Zhengming et al, CN 102626408a, 2012). It has been detected that 7-Substituted 1 H-indole-2,3-dione 3- [N-(substituted-phenyl) thiosemicarbazone] derivatives are very effective in inhibition of methicillin-resistant Staphylococcusaurei (MRSA) and vancomycin-resistant enterococcus (VRE) (Wang et al, CN 103483239 A, 2014). The studies of Karali et al related to 1 H-indole-2,3-dione N-alkyl/ cyclo-alkyl/ phenyl-3- thiosemicarbazone and its derivatives have shown that these derivatives are substantially anti-cancer and anti-tuberculosis effective (Karali 2002, Karali et al, 2002, Karali et al, 2007, Guzel et al, 2008). In the patent of Hall et al with title as methods for usage and definitions of compounds which are suitable for cancer cells which are resistant to medicine, said articles of Karali et al have been shown as reference, and within the scope of this study, the compounds recorded in the literature under the name of Karali et al have been tested, and it has been recorded that these compounds have substantial selective effect (2013/ EP 2240175 B1 ). , CH ₃ , OCF ₃ , F, Br, N0 ₂

, CH ₃ , morpholinomethyl, piperidinomethyl

n-alkyl (C1 -4), allyl, cyclo-hexyl, phenyl, 4- tuted phenyl, benzyl

P-glycoprotein (P-gp) plays an important role in formation of MDR - Multi-drug Resistance in cancer treatment. P-gp, whose synthesis substantially increases in cancer cells, substantially decreases the positive response to chemotherapy. Hall et al (2009 and 201 1 ) have tested the cyto-toxic effect of the 1 H-lndol-2,3-dione 3-thiosemicarbazone derivative compounds on these cancer cells producing excessive P-gp. This study has shown the importance of aromatic/hydrophobic residue in position N ⁴ of the isatin ring and thiosemi carbazone and this study has proven that N ⁴ -phenyl substituted thiosemi carbazone derivatives is much more effective than the N ⁴ -alkyl, N ⁴ -cycloalkyl and N ⁴ -non-substituted derivatives.

In another study where the anti-proliferative effect of 1 H-indole-2,3-dione thiosemi carbazone is searched, it has been determined that L3 compound has strong anti-proliferative effect on

) (Ali et al, 2014).

The structure-activity relation studies in 2-indolinon derivatives have shown that the electron attracting substituents in position 5 of the indole ring, N-alkylation and thiosemi carbazone formation increase efficiency against different virus and tumor cells (Vine et al, 2007) and moreover the studies have shown that by means of N-methylation, a small change has been detected in the activity, and by means of greater hydrophobic groups (allyl, tersiyer butyl- acetate, benzyl etc.), the N-alkylation results in effective derivatives at low nano-molar level. (Lee et al, 2001 ). Matesic et al (2008) have examined N-phenethyl, N-pheneacyl and N-(1 and 2-naphtylmethyl) isatin derivatives against different cancer cells, and they have recorded that the most efficient derivative in the test results is N-(l -naphtylmethyl). While the QSAR analyses (Sabet et al, 2010) of the isatin analogs with anti-cancer effect express the importance of the presence of the halogens attracting electron at positions 5 and 7 of the indole ring, and they have shown that an aromatic ring, bonded to the position-1 by means of 1 or 3 carbon chains, substantially affects the activity. It has been determined that 1 -Benzyl- 1 H-indole-2,3-dione 3-thiosemicarbazone is a non-toxic anti-oxidant and a promising anti- atherogenic agent (Barcelos et al, 2012). Moreover, the studies related to isatin 1 H-indole- 2,3-dione 3-thiosemicarbazone derivatives have proven that N ⁴ -phenyl substituted thiosemi carbazone derivatives are much more effective than the N ⁴ -alkyl, N ⁴ -cycloalkyl and N ⁴ -non- substituted derivatives.

The synthesis of seven new thiosemi carbazone derivatives obtained by the condensation of thiosemi carbazide derivatives having 4-Sulphamoilphenyl residue with substituted 1 H- indole-2,3-dione derivatives, the anti-cancer and anti-viral results thereof have been presented in Tetrahedron congress (Karali et al, 2013). In this congress, the activity findings of 1 H-indole-2,3-dione3-(4-sulphamoilphenyl)thiosemi-carbazone synthesized by Abdel- Rahman et al (2010) and whose biological activity scan has not been made have also been provided. These eight derivatives have been kept outside the scope of the patent.

R _{1 =} H, 5-CH ₃ , 5-OCF ₃ , 5-F, 5-CI, 5-Br, 5-N0 ₂ , 5,7-diBr

In the known state of the art, various 1 H-indole-2,3-dione derivatives and the anti-cancer, anti-viral and anti-inflammatory effects of the derivatives thereof having this structure have been recorded. In the related art, new therapeutic agents, which selectively target pathogen virus and bacteria and tumor cells without damaging healthy cells, are strongly required. These small molecules, which will act on enzyme systems which are seen as an important target in treatment of diseases like atherosclerotic vascular disease, diabetes, gout, Alzheimer, are strictly going to attract attention at the global level since they will play a critical role in pathogenesis of pluralities of inflammatory diseases. These molecules which are not recorded in literature and which are synthesized within the scope of the patent are compounds which will selectively target the treatment of said diseases.

OBJECT OF THE INVENTION

By means of the developed compounds, it is aimed to suppress specifically related enzyme or receptor mechanisms against various diseases including cancer and diseases in the immunity system, and thus, it will become possible to develop medicines which selectively target disease cells without damaging healthy cells and to become successful in the treatments and to minimize the side effects of the medicines. Accordingly, the basic object of the present invention is to synthesize Formula II and Formula III molecules which selectively target receptor or enzyme systems and which will provide overcoming of the disadvantages led by the agents which are present in the known state of the art.

Another object of the present invention is to determine the methods to be used in obtaining the molecules, shown by Formula II and Formula III, with high efficiency and in a pure manner. BRIEF DESCRIPTION OF THE INVENTION

One of the basic targets of searches for developing medicine against pluralities of diseases including cancer and diseases in the immunity system is to suppress the related enzyme or receptor mechanisms which are specific to the disease. However, the success of the treatments and the minimization of the side effects of medicines will become possible by means of developing medicines which selectively target disease cells and/or pathogens without damaging healthy cells.

Within the scope of the present invention, the molecules shown by Formula II and which are suitable for use in the treatment of various diseases and the -(non) substituted 1 H-indole-2,3- dione 3-thiosemi carbazone derivatives shown by Formula III are described.

Since 1 H-indole-2,3-dione derivatives and sulphonamide residue substantially increase the anti-cancer, anti-viral and anti-inflammatory effects, in this study, 2, 3 or 4-sulphamoil- phenylthio-semi-carbazides D have been used, and by means of interaction of these derivatives with derivatives II having 1 -alkyl, alkenyl, aralkyl, alkanoic acid, alkanoic acid alkyl ester of 1 H-indole-2,3-dione and 1 H-indole-2,3-dione, 1 -(non) substituted 1 H-indole-2,3- dione 3-thiosemi carbazone derivatives I II, which have sulphamoil residue in positions 2, 3 or 4 of the phenyl ring, have been synthesized. These derivatives have sulphonamide residue in position 4 of the phenyl ring. Within the scope of this study, substituted III derivatives have been synthesized which are at positions 1 , 5, 6 and/or 7 of the indole ring first having sulphonamide residue at positions 2 and 3 of the phenyl ring besides the III derivatives having 4-sulphonamideophenyl residue which are not recorded in the literature, and various synthesis methods of the III derivatives have been recorded. DETAILED DESCRIPTION OF THE INVENTION

From one perspective, the present invention relates to 2-indolinon derivative molecules whose general chemical structure is shown by Formula I I.

Here, F>1 is selected from a group comprising hydrogen, alkyl, metoxy, trifluorometoxy, halogen, nitro, carbonitryl, carboxamide, sodium sulphonate, sulphonamide.

F>2 is selected from a group comprising hydrogen, halogens.

F>3 is selected from a group comprising hydrogen, methyl, trifluoromethyl, metoxy, halogen. F>4 is independently selected from a group comprising alkyl, alkenil, alkanoic acid, alkanoic acid alkyl ester, benzyl, substituted benzyl, 1 -naphtylmethyl, 2-naphtylmethyl.

In Formula II,

In R said alkyl is selected from groups comprising methyl, isopropyl and tersiyer butyl. The halogen in F^ is selected from fluor, chlor, bromine and iodine groups.

The halogen in R ₂ is selected from fluor, chlor and bromine groups.

The halogen in R ₃ is selected from fluor, chlor and bromine groups.

In a preferred application of the present invention, in R _{1 :} fluor groups can be selected, and in R ₂ , chlor groups can be selected; in R _{1 :} chlor groups can be selected, and in R ₃ , methyl groups can be selected; in and R ₃ , dichlor groups can be selected; in and R ₃ , dibromine groups can be selected.

R ₄ is selected from a group comprising saturated or unsaturated, branched or unbranched Ci-3 alkyl, branched or unbranched C ₂ . ₄ alkanoic acid, branched or unbranched C ₂ . ₄ alkyl ester of C ₂ . ₄ branched or unbranched alkanoic acid.

R ₄ is selected from a group comprising saturated or unsaturated, branched or unbranched Ci-3 alkyl; methyl, ethyl, n-propyl, isopropyl, allyl. R ₄ is selected from a group comprising branched or unbranched C ₂ . ₄ alkanoic acid, acetic acid, 2-methyl acetic acid, propaneonic acid, butanoic acid. R ₄ is selected from a group comprising branched or unbranched C ₂ . ₄ alkyl ester of branched or unbranched alkanoic acid, ethyl acetate, isopropyl acetate, tersiyer butyl acetate, ethyl propanoate, ethyl 2-methylacetate, ethyl butanoate. In R ₄ , substituted benzyl carries Ci_ ₄ straight or branched alkyl, trifluoromethyl, metoxy, trifluorometoxy, fluor, chlor, bromine, iodine, nitro, carbonitryl, carboxy, hydroxy groups in positions 2, 3 or 4 of the phenyl ring. Here, as the Ci_ ₄ straight or branched alkyl, it is selected from a group comprising methyl, ethyl, isopropyl and tersiyer butyl groups. Substituted benzyl moreover may carry a group selected from 2,4-dimethyl, 2,5-dimethyl, 2,6-dimethyl, 3,4-dimethyl, 3,5-dimethyl, 2,3-difluor, 2,4-difluor, 2,5-difluor, 2,6-difluor, 3,4- difluor, 3,5-difluor, 2,4-dichlor, 2,6-dichlor, 3,4-dichlor, 3,5-dichlor, 2-chlor-4-fluor, 2-chlor-6- fluor, 3,4,5-trifluor, 2,3,4,5,6-pentafluor in phenyl ring.

The general chemical name of the compounds shown by Formula II is 1 -Substituted 1 7- indole-2,3-dione derivatives. In order to describe these molecules within the scope of the present invention, the terms of "Formula II" and/or Ί -substituted 1 H-indole-2,3-dione" can be interchangeably used.

In a preferred application of the present invention, as the Formula II compound, 1 -methyl-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide compound (Formula 11-1 ) is used. In order to describe this molecule within the scope of the present invention, the terms of "11-1 ", "Formula 11-1 " and/or "1 -methyl-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide" are interchangeably used. In a preferred application of the present invention, as the Formula II compound, 1 -Methyl-5- fluoro-6-chloro-1 7-indole-2,3-dione compound (Formula II-2) is used. In order to describe this molecule within the scope of the present invention, the terms of "II-2", "Formula II-2" and/or "1 -Methyl-5-fluoro-6-chloro-1 - -indole-2,3-dione" are interchangeably used. The particular examples described in the present invention and belonging to the molecules shown by Formula II are given below. These examples have been given for describing the present invention in a better manner, and the invention is not limited to these examples in any manner. The chemical structures given in the examples show the R ₄ group, and the R ₂ and R ₃ groups to be used are selected from the R _{1 :} R ₂ , R ₃ groups described above, and naming is realized accordingly. In an application of the present invention, the compounds shown by Formula II are selected l-1 H-indole-2,3-dione

and from the derivatives thereof, for instance 1 -Methyl-2,3-dioxo-2,3-dihydro-1 7-indole-5- sulphonamide, 1 -Methyl-5-fluoro-6-chloro-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected

H-indole-2,3-dione

and from the derivatives thereof, for instance 1 -Ethyl-5-trifluorometoxy-1 7-indole-2,3-dione, 1 -Ethyl-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, Sodium 1 -ethyl-2,3-dioxo, 2,3-dihydro- 1 H-indole-5-sulphonate, 1 -Ethyl-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -Ethyl-7- trifluoromethyl-1 H-indole-2,3-dione, 1 -Ethyl-5-fluoro-6-chloro-1 H-indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected l-1 H-indole-2,3-dione

and from the derivatives thereof, for instance 1 -Propyl-5-(propane-2-yl)-1 H-indole-2,3-dione, 1 - Propyl-5-t-butyl-1 7-indole-2,3-dione, 1 -Propyl-5-trifluorometoxy-1 7-indole-2,3-dione, 1 - Propyl-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 - Propyl-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 - Propyl-7-trifluoromethyl-1 H-indole-2,3-dione, 1 - Propyl-7-metoxy- 1 H-indole-2,3-dione, 1 - Propyl-5-fluoro-6-chloro-1 7-indole-2,3-dione, 1 - Propyl-5-chloro-7- methyl-1 H-indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 1 -(Propane-2-yl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(Propane-2-yl)-5-trifluorometoxy-1 Hindole-2,3-dione, 1 -(Propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(Propane-2-yl)-2,3-dioxo- 2,3-dihydro-1 Hindole-5-carboxamide, Sodium 1 -(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 1 -(Propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 - (Propane-2-yl)-7-trif luoromethyl-1 H-indole-2,3-dione, 1 -(Propane-2-yl)-5-fluoro-6-chloro-1 H- indole-2,3-dione, 1 -(Propane-2-yl)-5-chloro-7-methyl-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected nyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2-Propenyl)-5-(propane-2-yl)-1 H-indole-2,3-dione, 1 - (2-Propenyl)-5-t-butyl-1 H-indole-2,3-dione, 1 -(2-Propenyl)-5-trifluorometoxy-1 H-indole-2,3- dione, 1 -(2-Propenyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2-Propenyl)-2,3- dioxo-2,3-dihydro-1 7-indole-5-carboxamide, 1 -(2-Propenyl)-2,3-dioxo-2,3-dihydro-1 H-indole- 5-sulphonamide, 1 -(2-Propenyl)-7-trif luoromethyl-1 H-indole-2,3-dione, 1 -(2-Propenyl)-7- metoxy-1 7-indole-2,3-dione, 1 -(2-Propenyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected -Dioxo-2,3-dihydro-1 H-indole-1 -acetic acid

and from its derivatives, for instance 5- t-Butyl-2,3-dioxo-2,3-dihydro-1 7-indole-1 -aceticacid, 5-Trifluorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -aceticacid, 5-Cyano-2,3-dioxo-2,3- dihydro-1 H-indole-1 -aceticacid, 5-Karbamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -aceticacid, sodium 1 -(carboxymethyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 5-Sulphamoil-2,3- dioxo-2,3-dihydro-1 H-indole-1 -aceticacid, 7-Metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 - aceticacid, 5-Fluoro-6-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -aceticacid, 5-Chloro-7- methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -aceticacid, 5,7-Dibromo-2,3-dioxo-2,3-dihydro-1 H- indole-1 -acetic acid.

In an application of the present invention, the compounds shown by Formula II are selected ihydro-1 7-indole-1 -yl)propaneoic acid

and from its derivatives, for instance 3-[5-(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propaneoic acid,3-[5-t-butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propaneoic acid, 3- [5- trifluorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propaneoic acid,3-[5-iyodo-2,3-dioxo- 2,3-dihydro-1 H-indole-1 -yl]propaneoic acid,3-[5-cyano-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propaneoic acid,3-[5-karbamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propaneoic acid, Sodium 1 -(2-carboxyethyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 3-[5-sulphamoil- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propaneoic acid,3-[7-trifluoromethyl-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl]propaneoic acid,3-[7-metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propaneoic acid,3-[5-f luoro-6-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propaneoic acid,3-[5-chloro-7-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propaneoic acid,3-[5,7- dichloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propaneoic acid,3-[5,7-dibromo-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl]propaneoic acid. In an application of the present invention, the compounds shown by Formula II are selected

-2,3-dihydro-1 H-indole-1 -yl)propaneoic acid

and from its derivatives, for instance2-[5-(Propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propaneoic acid, 2-(5-t-Butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)propaneoic acid, 2-(5- Trifluorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)propaneoic acid, 2-(5-Karbamoil-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)propaneoic acid, Sodium 1 -(1 -carboxyethyl)-2,3-dioxo-2,3- dihydro-1 H-indole-5-sulphonate, 2-(5-Sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)propaneoic acid, 2-(7-Trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)propaneoic acid, 2-(7-Metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)propaneoic acid, 2-(5-Chloro-7- methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)propaneoic acid, 2-(5-Fluoro-6-chloro-2,3-dioxo- 2,3-dihydro-1 H-indole-1 -yl)propaneoic acid, 2-(5,7-Dibromo-2,3-dioxo-2,3-dihydro-1 H-indole- 1 -yl)propaneoic acid.

In an application of the present invention, the compounds shown by Formula II are selected

-2,3-dihydro-1 7-indole-1 -yl)butanoic acid

and from its derivatives, for instance 4-(5-(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 7-indole-1 - yl)butanoicacid,4-(5-t-butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoicacid, 4-(5- trifluorometoxy-2,3-dioxo-2,3-dihydro-1 - -indole-1 -yl)butanoicacid,4-(5-iyodo-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl)butanoicacid,4-(5-nitro-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)butanoicacid,4-(5-cyano-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoicacid, 4-(5-karbamoil- 2, 3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoic acid, Sodium 1 -(3-carboxypropyl)-2,3-dioxo- 2,3-dihydro-1 H-indole-5-sulphonate, 4-(5-sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)butanoicacid,4-(7-trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoicacid,4-(7- metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoicacid,4-(5-fluoro-6-chloro-2,3-dioxo-2, 3- dihydro-1 H-indole-1 -yl)butanoicacid,4-(5-chloro-7-methyl-2,3-dioxo-2,3-dihydro- 1 H-indole-1 - yl)butanoicacid,4-(5,7-dichloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoicacid,4-(5, 7- dibromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoic acid. In an application of the present invention, the compounds shown by Formula II are selected dihydro-1 H-indole-1 -acetate

and from its derivatives, for instance ethyl 5-(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole- 1 -acetate, ethyl 5- t-butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, ethyl 5-trifluorometoxy- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, ethyl 5-iyodo-2,3-dioxo-2,3-dihydro-1 H-indole-1 - acetate, ethyl 5-cyano-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, ethyl 5-karbamoil-2,3- dioxo-2,3-dihydro-1 H-indole-1 -acetate, Sodium 1 -(2-etoxy-2-oxoethyl)-2,3-dioxo-2,3-dihydro- 1 H-indole-5-sulphonate, ethyl 5-sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, ethyl 7-trif luoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 acetate, ethyl 7-metoxy-2,3-dioxo-2,3- dihydro-1 H-indole-1 acetate, ethyl 5-f luoro-6-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 acetate, ethyl 5-chloro-7-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 acetate. In an application of the present invention, the compounds shown by Formula II are selected oxo-2,3-dihydro-1 H-indole-1 -acetate

and from its derivatives, for instancePropane-2-yl 5-(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H- indole-1 -acetate, Propane-2-yl 5-t-butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Propane- 2-yl 5-trifluorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Propane-2-yl 5-iyodo-2,3- dioxo-2,3-dihydro-1 H-indole-1 -acetate, Propane-2-yl 5-cyano-2,3-dioxo-2,3-dihydro-1 H- indole-1 -acetate, Propane-2-yl 5-karbamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Sodium 1 -[2-oxo-2-(propane-2-yloxy)ethyl]-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, Propane-2-yl 5-sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Propane-2-yl 7- trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Propane-2-yl 7-metoxy-2,3-dioxo- 2,3-dihydro-1 H-indole-1 -acetate, Propane-2-yl 7-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 - acetate, Propane-2-yl 5-fluoro-6-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Propane- 2-yl 5-chloro-7-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Propane-2-yl 5,7-dichloro- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Propane-2-yl 5,7-dibromo-2,3-dioxo-2,3-dihydro- 1 H-indole-1 -acetate.

In an application of the present invention, the compounds shown by Formula II are selected dihydro-1 H-indole-1 -acetate

and from its derivatives, for instance t-Butyl 5-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - acetate, t-Butyl 5-(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 5-t-butyl- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 5-trif luorometoxy-2,3-dioxo-2,3-dihydro- 1 H-indole-1 -acetate, t-Butyl 5-fluoro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 5- iyodo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 5-cyano-2,3-dioxo-2,3-dihydro-1 H- indole-1 -acetate, t-Butyl 5-karbamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, Sodium 1 - (2-t-butoxy-2-oxoethyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, t-Butyl 5-sulphamoil- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 6-chloro-2,3-dioxo-2,3-dihydro-1 H-indole- 1 -acetate, t-Butyl 6-bromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 7-methyl-2,3- dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 7-trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H- indole-1 -acetate, t-Butyl 7-metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 7- fluoro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 7-chloro-2,3-dioxo-2,3-dihydro-1 H- indole-1 -acetate, t-Butyl 7-bromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 5-fluoro- 6-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 5-chloro-7-methyl-2,3-dioxo-2,3- dihydro-1 H-indole-1 -acetate, t-Butyl 5,7-dichloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate, t-Butyl 5,7-dibromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -acetate.

In an application of the present invention, the compounds shown by Formula II are selected ydro-1 H-indole-1 -yl)propanoate

and from its derivatives, for instance ethyl 3-[5-(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl]propanoate, ethyl 3-[5-t-butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 3-[5-trifluorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 3-[5-iyodo- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 3-[5-cyano-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl]propanoate, ethyl 3-[5-karbamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propanoate, Sodium 1 -(3-etoxy-3-oxopropyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, ethyl 3-[5-sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 3- [7-trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 3-[7-metoxy-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 3-[5-fluoro-6-chloro-2,3-dioxo-2,3-dihydro- 1 H-indole-1 -yl]propanoate, ethyl 3-[5-chloro-7-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propanoate, ethyl 3-[5,7-dichloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 3- [5,7-dibromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate.

In an application of the present invention, the compounds shown by Formula II are selected from ethyl 2-(2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)propanoate

and from its derivatives, for instance ethyl 2-[5-(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl]propanoate, ethyl 2-[5-t-butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5-metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5- trifluorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5-f luoro-2,3-dioxo- 2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5-iyodo-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propanoate, ethyl 2-[5-nitro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5- cyano-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5-karbamoil-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl]propanoate, Sodium 1 -(1 -etoxy-1 -oxopropane-2-yl)-2,3-dioxo-2,3- dihydro-1 H-indole-5-sulphonate, ethyl 2-[5-sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propanoate, ethyl 2-[6-fluoro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[6- chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[6-bromo-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[7-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propanoate, ethyl 2-[7-metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[7- trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[7-chloro-2,3-dioxo- 2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[7-bromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl]propanoate, ethyl 2-[5-fluoro-6-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5-chloro-7-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5,7- dichloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl]propanoate, ethyl 2-[5,7-dibromo-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl]propanoate.

In an application of the present invention, the compounds shown by Formula II are selected o-1 H-indole-1 -yl)butanoat

and from its derivatives, for instance ethyl 4-(5-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)butanoat, ethyl 4-(5-(propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4- (5-t-butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5-metoxy-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5-trifluorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole- 1 -yl)butanoat, ethyl 4-(5-fluoro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5- chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5-bromo-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5-iyodo-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)butanoat, ethyl 4-(5-nitro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5-cyano- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5-karbamoil-2,3-dioxo-2,3-dihydro- 1 H-indole-1 -yl)butanoat, Sodium 1 -(4-etoxy-4-oxobutyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, ethyl 4-(5-sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(6- fluoro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(6-chloro-2,3-dioxo-2,3-dihydro- 1 H-indole-1 -yl)butanoat, ethyl 4-(6-bromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(7-trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(7-metoxy- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(7-fluoro-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)butanoat, ethyl 4-(7-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4- (7-bromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5-fluoro-6-chloro-2,3-dioxo- 2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5-chloro-7-methyl-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)butanoat, ethyl 4-(5,7-dichloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat, ethyl 4-(5,7-dibromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)butanoat.

In an application of the present invention, the compounds shown by Formula II are selected

1 H-indole-2,3-dione

and from its derivatives, for instance 1 -Benzyl-7-metoxy-1 H-indole-2,3-dione,1 -Benzyl-5- fluoro-6-chloro-1 H-indole-2,3-dione,1 -Benzyl-5,7-dichloro-1 Hindole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected ylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-Methylbenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(4-Methylbenzyl)-5-t-butyl-1 H-indole-2,3-dione, 1 -(4-Methylbenzyl)-5-trifluorometoxy- 1 H-indole-2,3-dione,1 -(4-Methylbenzyl)-5-iyodo-1 H-indole-2,3-dione ϋ 1 -(4-Methylbenzyl)- 2,3-dioxo-2,3-dihydro-1 - -indole-5-carbonitryl, Sodium 1 -(4-methylbenzyl)-2,3-dioxo-2,3- dihydro-1 7-indole-5-sulphonate, 1 -(4-Methylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonamide, 1 -(4-Methylbenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(4-Methylbenzyl)-5- fluoro-6-chloro-1 Hindole-2,3-dione,1 -(4-Methylbenzyl)-5-chloro-7-methyl-1 H-indole-2,3- dione,1 -(4-Methylbenzyl)-5,7-dichloro-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected oromethylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-Trif luoromethylbenzyl)-5-(propane-2-yl)-1 H-indole- 2,3-dione,1 -(4-Trifluoromethylbenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(4- Trifluoromethylbenzyl)-5-metoxy-1 - -indole-2,3-dione,1 -(4-Trif luoromethylbenzyl)-5-bromo- 1 H-indole-2,3-dione,1 -(4-Trifluoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5- carbonitryl, 1 -(4-Trifluoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(4-trifluoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5-sulphonate, 1 -(4- Trif luoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(4-

Trifluoromethylbenzyl)-6-fluoro-1 - -indole-2,3-dione,1 -(4-Trif luoromethylbenzyl)-6-chloro-1 7- indole-2,3-dione,1 -(4-Trifluoromethylbenzyl)-7-methyl-1 H-indole-2,3-dione,1 -(4- Trifluoromethylbenzyl)-7-metoxy-1 - -indole-2,3-dione,1 -(4-Trif luoromethylbenzyl)-5-fluoro-6- chloro-1 H-indole-2,3-dione,1 -(4-Trifluoromethylbenzyl)-5-chloro-7-methyl-1 H-indole-2,3- dione,1 -(4-Trif luoromethylbenzyl)-5,7-dichloro-1 - -indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected enzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-Metoxybenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(4-Metoxybenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(4-Metoxybenzyl)-2,3-dioxo-2,3- dihydro-1 - -indole-5-carbonitryl, 1 -(4-Metoxybenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5- carboxamide, Sodium 1 -(4-metoxybenzyl)-2,3-dioxo-2,3-dihydro-1 Hindole-5-sulphonate, 1 - (4-Metoxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(4-Metoxybenzyl)-7- metoxy-1 H-indole-2,3-dione,1 -(4-Metoxybenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 -(4- Metoxybenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione, 1 -(4-Metoxybenzyl)-57-dichloro-1 H- indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 - 4-Trif luorometoxybenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-Trifluorometoxybenzyl)-5-(propane-2-yl)-1 H-indole- 2,3-dione,1 -(4-Trifluorometoxybenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(4- Trifluorometoxybenzyl)-5-metoxy-1 - -indole-2,3-dione,1 -(4-Trif luorometoxybenzyl)-5-bromo- 1 H-indole-2,3-dione,1 -(4-Trifluorometoxybenzyl)-5-iyodo-1 - -indole-2,3-dione,1 -(4- Trifluorometoxybenzyl)-5-nitro-1 - -indole-2,3-dione, 1 -(4-Trifluorometoxybenzyl)-2,3-dioxo- 2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(4-Trifluorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carboxamide, Sodium 1 -(4-trif luorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole- 5-sulphonate, 1 -(4-Trif luorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(4-Trifluorometoxybenzyl)-6-fluoro-1 - -indole-2,3-dione,1 -(4-Trifluorometoxybenzyl)-6- chloro-1 H-indole-2,3-dione,1 -(4-Trifluorometoxybenzyl)-6-bromo-1 - -indole-2,3-dione,1 -(4- Trifluorometoxybenzyl)-7-methyl-1 H-indole-2,3-dione,1 -(4-Trif luorometoxybenzyl)-7- trifluoromethyl-1 H-indole-2,3-dione,1 -(4-Trifluorometoxybenzyl)-7-metoxy-1 H-indole-2,3- dione,1 -(4-Trifluorometoxybenzyl)-5-fluoro-6-chloro-1 - -indole-2,3-dione,1 -(4- Trifluorometoxybenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(4-Trif luorometoxybenzyl)- 5,7-dichloro-1 H-indole-2,3-dione,1 -(4-Trifluorometoxybenzyl)-5,7-dibromo-1 - -indole-2,3- dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(4-Fluorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-Fluorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(4-Fluorobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(4-Fluorobenzyl)-5-iyodo-1 A7-indole- 2,3-dione,1 -(4-Fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5-carbonitryl, 1 -(4- Fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 Hindole-5-carboxamide, Sodium 1 -(4-forobenzyl)-2,3- dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(4-Fluorobenzyl)-7-metoxy-1 H-indole-2,3- dione,1 -(4-Fluorobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 -(4-Fluorobenzyl)-5-chloro- 7-methyl-1 H-indole-2,3-dione,1 -(4-Fluorobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(4- Fluorobenzyl)-5,7-dibromo-1 - -indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(4-Chlorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-Chlorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(4-Chlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(4-Chlorobenzyl)- 2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(4-chlorobenzyl)-2,3-dioxo-2,3- dihydro-1 7-indole-5-sulphonate, 1 -(4-Chlorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonamide, 1 -(4-Chlorobenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(4-Chlorobenzyl)-5- fluoro-6-chloro-1 - -indole-2,3-dione,1 -(4-Chlorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3- dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(4-Bromobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-Bromobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(4-Bromobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(4-Bromobenzyl)-5-iyodo-1 - -indole- 2,3-dione,1 -(4-Bromobenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5-carbonitryl, 1 -(4- Bromobenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5-carboxamide, Sodium 1 -(4-bromobenzyl)- 2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(4-Bromobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(4-Bromobenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(4-

Bromobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 -(4-Bromobenzyl)-5-chloro-7-methyl- 1 H-indole-2,3-dione,1 -(4-Bromobenzyl)-5,7-dichloro-1 - -indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(4-iyodobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-iyodobenzyl)- 5-(propane-2-yl)-1 H-indole-2,3- dionel -(4-iyodobenzyl)- 5-t-butyl-1 H-indole-2,3-dione,1 -(4-iyodobenzyl)-5-trifluorometoxy- 1 H-indole-2,3-dione,1 -(4-iyodobenzyl)-5-iyodo-1 7-indole-2,3-dione,1 -(4-iyodobenzyl)-5-nitro- 1 H-indole-2,3-dione,1 -(4-iyodobenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5-carbonitryl, 1 -(4- iyodobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(4-iyodobenzyl)-2,3- dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(4-iyodobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(4-iyodobenzyl)-7-trif luoromethyl-1 H-indole-2,3-dione,1 -(4- iyodobenzyl)-7-metoxyl-1 - -indole-2,3-dione,1 -(4-iyodobenzyl)-5-chloro-7-methyl-1 H-indole- 2,3-dione,1 -(4-iyodobenzyl)-5-fluoro-6-chloro-1 7-indole-2,3-dione,1 -(4-iyodobenzyl)-5,7- dichloro-1 H-indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 1 -(4-Nitrobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(4-Nitrobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(4-Nitrobenzyl)-5-t-butyl-1H-indole-2,3-dione,1-(4-N itrobenzyl)-2,3-dioxo-2,3-dihydro- 1 H-indole-5-carbonitryl, 1 -(4-Nitrobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1-(4-nitrobenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-sulphonate, 1-(4-Nitrobenzyl)- 2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(4-Nitrobenzyl)-6-chloro-1 H-indole-2,3- dione,1-(4-Nitrobenzyl)-7-methyl-1H-indole-2,3-dione,1-(4-Ni trobenzyl)-7-trifluoromethyl-1H- indole-2,3-dione,1-(4-Nitrobenzyl)-7-metoxy-1 --indole-2,3-dione,1-(4-Nitrobenzyl)-7-fluoro- 1H-indole-2,3-dione,1-(4-Nitrobenzyl)-7-chloro-1H-indole-2,3 -dione,1-(4-Nitrobenzyl)-5- fluoro-6-chloro-1H-indole-2,3-dione.1-(4-Nitrobenzyl)-5-chlo ro-7-methyl-1H-indole-2,3- dione,1 -(4-Nitrobenzyl)-5,7-dichloro-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(4-Cyanobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(4-Cyanobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(4-Cyanobenzyl)-5-t-butyl-1 --indole-2,3-dione,1-(4-Cyanobenzyl)-5-metoxy-1 -- indole-2,3-dione,1-(4-Cyanobenzyl)-5-trifluorometoxy-1 --indole-2,3-dione,1-(4- Cyanobenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(4-Cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carbonitryl, 1 -(4-Cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(4-cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(4-

Cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(4-Cyanobenzyl)-7- trifluoromethyl-1H-indole-2,3-dione,1-(4-Cyanobenzyl)-7-meto xy-1 H-indole-2,3-dione,1-(4- Cyanobenzyl)-5-fluoro-6-chloro-1 --indole-2,3-dione,1-(4-Cyanobenzyl)-5-chloro-7-methyl- 1H-indole-2,3-dione,1-(4-Cyanobenzyl)-5,7-dichloro-1 7-indole-2,3-dione,1-(4-Cyanobenzyl)- 5,7-dibromo-1 H-indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected nzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(4-Ethylbenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(4-Ethylbenzyl)-5-t-butyl-1 --indole-2,3-dione,1-(4-Ethylbenzyl)-5-metoxy-1 --indole- 2,3-dione,1-(4-Ethylbenzyl)-5-trifluorometoxy-1 H-indole-2,3-dione,1-(4-Ethylbenzyl)-5-iyodo- 1H-indole-2,3-dione,1-(4-Ethylbenzyl)-5-nitro-1H-indole-2,3- dione,1-(4-Ethylbenzyl)-2,3- dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(4-Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole- 5-carboxamide, Sodium 1-(4-Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1- (4-Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(4-Ethylbenzyl)-6-fluoro- 1H-indole-2,3-dione,1-(4-Ethylbenzyl)-7-trifluoromethyl-1H-i ndole-2,3-dione,1-(4- Ethylbenzyl)-7-metoxy-1 --indole-2,3-dione,1-(4-Ethylbenzyl)-5-fluoro-6-chloro-1 --indole-2,3- dione,1-(4-Ethylbenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1-(4-Ethylbenzyl)-5,7- dichloro-1 --indole-2,3-dione,1-(4-Ethylbenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected e-2-yl)benzyl]-1 H-indole-2,3-dione

and from its derivatives, for instance 1-[4-(propane-2-yl)benzyl]-5-methyl-1 H-indole-2,3- dione,1-[4-(propane-2-yl)benzyl]-5-(propane-2-yl)-1H-indole- 2,3-dione,1-[4-(propane-2- yl)benzyl]-5-t-butyl-1H-indole-2,3-dione,1-[4-(propane-2-yl) benzyl]-5-metoxy-1H-indole-2,3- dione,1-[4-(propane-2-yl)benzyl]-5-trifluorometoxy-1H-indole -2,3-dione,1-[4-(propane-2- yl)benzyl]-5-fluoro-1 7-indole-2,3-dione,1-[4-(propane-2-yl)benzyl]-5-chloro-1 H-indole-2,3- dione,1-[4-(propane-2-yl)benzyl]-5-bromo-1H-indole-2,3-dione ,1-[4-(propane-2-yl)benzyl]-5- iyodo-1 7-indole-2,3-dione,1-[4-(propane-2-yl)benzyl]-5-nitro-1 --indole-2,3-dione,1-[4- (propane-2-yl)benzyl]-2,3-dioxo-2,3-dihydro-1H-indole-5-carb onitryl, 1-[4-(propane-2- yl)benzyl]-2,3-dioxo-2,3-dihydro-1 H-indole-5-carboxamide, Sodium 1 -[4-(propane-2- yl)benzyl]-2,3-dioxo-2,3-dihydro-1H-indole-5-sulphonate, 1-[4-(propane-2-yl)benzyl]-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -[4-(propane-2-yl)benzyl]-6-fluoro-1 H-indole- 2,3-dione -[4-(propane-2-yl)benzyl]-6-chloro-1H-indole-2,3-dione,1-[4- (propane-2-yl)benzyl]- 6-bromo-1 H-indole-2,3-dione,1-[4-(propane-2-yl)benzyl]-7-methyl-1H-in dole-2,3-dione,1-[4- (propane-2-yl)benzyl]-7-trifluoromethyl-1H-indole-2,3-dione, 1-[4-(propane-2-yl)benzyl]-7- metoxy-1Hindole-2,3-dione,1-[4-(propane-2-yl)benzyl]-7-fluor o-1 --indole-2,3-dione,1-[4- (propane-2-yl)benzyl]-7-chloro-1 H-indole-2,3-dione,1 -[4-(propane-2-yl)benzyl]-7-bromo-1 H- indole-2,3-dione,1-[4-(propane-2-yl)benzyl]-5-fluoro-6-chlor o-1 H-indole-2,3-dione,1-[4-

(propane-2-yl)benzyl]-5-chloro-7-methyl-1H-indole-2,3-dio ne,1-[4-(propane-2-yl)benzyl]-5,7- dichloro-1 --indole-2,3-dione,1-[4-(propane-2-yl)benzyl]-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected nzyl)-1H-indole-2,3-dione

and from its derivatives, for instance 1-(4-t-butylbenzyl)-5-methyl-1H-indole-2,3-dione,1-(4-t- butylbenzyl)-5-(propane-2-yl)-1Hindole-2,3-dione,1-(4-t-buty lbenzyl)-5-t-butyl-1H-indole-2,3- dione,1-(4- t-butylbenzyl)-5-metoxy-1 --indole-2,3-dione,1-(4- t-butylbenzyl)-5- trifluorometoxy-1 H-indole-2,3-dione,1-(4- t-butylbenzyl)-5-chloro-1 7-indole-2,3-dione,1-(4- t- butylbenzyl)-5-bromo-1 --indole-2,3-dione,1-(4- t-butylbenzyl)-5-iyodo-1 H-indole-2,3-dione,1- (4-t-butylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1-(4-t-butylbenzyl)-2,3-dioxo- 2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(4-t-butylbenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 1 -(4-t-butylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 - (4-t-butylbenzyl)-6-fluoro1H-indole-2,3-dione,1-(4-t-butylbe nzyl)-6-chloro-1H-indole-2,3- dione,1-(4-t-butylbenzyl)-7-methyl-1 H-indole-2,3-dione,1-(4-t-butylbenzyl)-7-metoxy-1 -- indole-2,3-dione,1-(4-t-butylbenzyl)-7-fluoro1 --indole-2,3-dione,1-(4-t-butylbenzyl)-7-chloro- 1H-indole-2,3-dione,1-(4-t-butylbenzyl)-5-fluoro-6-chloro-1H -indole-2,3-dione,1-(4- t- butylbenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(4-t-butylbenzyl)-5,7-dichloro-1 H- indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected ,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid

and from its derivatives, for instance 4-[(5-(Propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid,4-[(5-t-Butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5-Metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5- Trif luorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5-Chloro-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5-Bromo-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)methyl]benzoic acid,4-[(5-iyodo-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid,4-[(5-Nitro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5-Cyano-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5-Karbamoil- 2, 3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, Sodium 1 -(4-carboxybenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 4-[(5-Sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole- 1 -yl)methyl]benzoic acid,4-[(6-Chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(6-Bromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(7-Methyl-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(7-Trifluoromethyl-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(7-Metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid,4-[(7-Fluoro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(7-Chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5-Fluoro-6- chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5-Chloro-7-methyl-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,4-[(5,7-Dichloro-2,3-dioxo-2,3-dihydro- 1 H-indole-1 -yl)methyl]benzoic acid.

In an application of the present invention, the compounds shown by Formula II are selected benzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(4-Hydroxybenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(4-Hydroxybenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(4-Hydroxybenzyl)-5- trifluorometoxy-1 H-indole-2,3-dione, 1 -(4-Hydroxybenzyl)-5-iyodo-1 - -indole-2,3-dione,1 -(4- Hydroxybenzyl)-2,3-dioxo-2,3-dihydro-1 A7-indole-5-carbonitryl, 1 -(4-Hydroxybenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-carboxamide, Sodium 1 -(4-hydroxybenzyl)-2,3-dioxo-2,3- dihydro-1 7-indole-5-sulphonate, 1 -(4-Hydroxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonamide, 1 -(4-Hydroxybenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1 -(4- Hydroxybenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(4-Hydroxybenzyl)-5-fluoro-6-chloro-1 - - indole-2,3-dione,1 -(4-Hydroxybenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(4- Hydroxybenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(4-Hydroxybenzyl)-5,7-dibromo-1 H- indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected lbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(3-Methylbenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(3-Methylbenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(3-Methylbenzyl)-5-trifluorometoxy- 1 H-indole-2,3-dione,1 -(3-Methylbenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(3-Methylbenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-carbonitryl,1 -(3-Methylbenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carboxamide, Sodium 1 -(3-methylbenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5- sulphonate, 1 -(3-Methylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3- Methylbenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione, 1 -(3-Methylbenzyl)-7-metoxy-1 H-indole- 2,3-dione,1 -(3-Methylbenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 -(3-Methylbenzyl)-5- chloro-7-methyl-1 H-indole-2,3-dione,1 -(3-Methylbenzyl)-5,7-dichloro-1 - -indole-2,3-dione,1 - (3-Methylbenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3-Trif luoromethylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3-Trifluoromethylbenzyl)-5-(propane-2-yl)-1H-indole- 2,3-dione,1-(3-Trifluoromethylbenzyl)-5-t-butyl-1H-indole-2, 3-dione,1-(3- Trifluoromethylbenzyl)-5-metoxy-1 --indole-2,3-dione,1-(3-Trifluoromethylbenzyl)-5- trifluorometoxy-1 H-indole-2,3-dione,1-(3-Trifluoromethylbenzyl)-5-bromo-1 --indole-2,3- dione,1-(3-Trifluoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-carbonitryl,1-(3- Trif luoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, sodium 1 -(3- trifluoromethylbenzyl)-2,3, dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3-

Trif luoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3- Trifluoromethylbenzyl)-6-fluoro-1 --indole-2,3-dione,1-(3-Trifluoromethylbenzyl)-6-chloro-1 -- indole-2,3-dione,1-(3-Trifluoromethylbenzyl)-6-bromo-1 --indole-2,3-dione,1-(3- Trifluoromethylbenzyl)-7-trifluoromethyl-1H-indole-2,3-dione ,1-(3-Trifluoromethylbenzyl)-7- metoxy-1 --indole-2,3-dione,1-(3-Trifluoromethylbenzyl)-7-bromo-1 --indole-2,3-dione.1-(3- Trifluoromethylbenzyl)-5-fluoro-6-chloro-1 --indole-2,3-dione,1-(3-Trifluoromethylbenzyl)-5- chloro-7-methyl-1H-indole-2,3-dione,1-(3-Trifluoromethylbenz yl)-5,7-dichloro-1 H-indole-2,3- dione,1-(3-Trifluoromethylbenzyl)-5,7-dibromo-1 --indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected enzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3-Metoxybenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(3-Metoxybenzyl)-5-t-butyl-1 H-indole-2,3-dione,1-(3-Metoxybenzyl)-5-metoxy-1 7- indole-2,3-dione,1-(3-Metoxybenzyl)-5-iyodo-1 --indole-2,3-dione,1-(3-Metoxybenzyl)-5-nitro- 1H-indole-2,3-dione,1-(3-Metoxybenzyl)-2,3-dioxo-2,3-dihydro -1 --indole-5-carbonitryl, Sodium 1 -(3-metoxybenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3- Metoxybenzyl)-2,3-dioxo-2,3-dihydro-1 Hindole-5-sulphonamide, 1 -(3-Metoxybenzyl)-7- trifluoromethyl-1 H-indole-2,3-dione -(3-Metoxybenzyl)-7-metoxy-1 Hindole-2,3-dione,1 -(3- Metoxybenzyl)-5 luoro-6-chloro-1 Hindole-2,3-dione -(3-Metoxybenzyl)-5-chloro-7-methyl- 1 H-indole-2,3-dione,1 -(3-Metoxybenzyl)-5,7-dichloro-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected ometoxybenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(3-Trifluorometoxybenzyl)-1 H-indole-2,3-dione,1 -(3- Trifluorometoxybenzyl)-5-methyl-1 H-indole-2,3-dione,1 -(3-Trif luorometoxybenzyl)-5- (propane-2-yl)-1 H-indole-2,3-dione,1 -(3-Trifluorometoxybenzyl)-5-t-butyl-1 - -indole-2,3- dione,1 -(3-Trifluorometoxybenzyl)-5-metoxy-1 - -indole-2,3-dione,1 -(3- Trifluorometoxybenzyl)-5-trifluorometoxy-1 H-indole-2,3-dione,1 -(3-Trif luorometoxybenzyl)-5- fluoro-1 H-indole-2,3-dione,1 -(3-Trifluorometoxybenzyl)-5-chloro-1 - -indole-2,3-dione,1 -(3- Trifluorometoxybenzyl)-5-bromo-1 H-indole-2,3-dione,1 -(3-Trif luorometoxybenzyl)-5-iyodo- 1 H-indole-2,3-dione,1 -(3-Trifluorometoxybenzyl)-5-nitro-1 H-indole-2,3-dione,1 -(3- Trifluorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl,1 -(3- Trif luorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3- trifluorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3-

Trif luorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3-

Trifluorometoxybenzyl)-6-fluoro-1 H-indole-2,3-dione,1 -(3-Trif luorometoxybenzyl)-6-chloro- 1 H-indole-2,3-dione,1 -(3-Trifluorometoxybenzyl)-7-methyl-1 H-indole-2,3-dione. 1 -(3- Trifluorometoxybenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione. 1 -(3-Trifluorometoxybenzyl)-7- metoxy-1 - -indole-2,3-dione,1 -(3-Trifluorometoxybenzyl)-7-fluoro-1 - -indole-2,3-dione,1 -(3- Trifluorometoxybenzyl)-7-chloro-1 H-indole-2,3-dione,1 -(3-Trif luorometoxybenzyl)-7-bromo- 1 H-indole-2,3-dione,1 -(3-Trifluorometoxybenzyl)-5-fluoro-6-chloro-1 - -indole-2,3-dione,1 -(3- Trifluorometoxybenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(3-Trif luorometoxybenzyl)- 5,7-dichloro-1 H-indole-2,3-dione,1 -(3-Trifluorometoxybenzyl)-5,7-dibromo-1 - -indole-2,3- dione. In an application of the present invention, the compounds shown by Formula II are selected benzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(3-Fluorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(3-Fluorobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(3-Fluorobenzyl)-5-trifluorometoxy- 1 H-indole-2,3-dione,1 -(3-Fluorobenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(3-Fluorobenzyl)-2,3- dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(3-Fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carboxamide, Sodium 1 -(3-f luorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, 1 -(3-Fluorobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione, 1 -(3-Fluorobenzyl)-7- metoxy-1 - -indole-2,3-dione,1 -(3-Fluorobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 -(3- Fluorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(3-Fluorobenzyl)-5,7-dichloro-1 H- indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected enzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(3-Chlorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(3-Chlorobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(3-Chlorobenzyl)-5-trifluorometoxy- 1 H-indole-2,3-dione,1 -(3-Chlorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(3- Chlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3-chlorobenzyl)- 2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(3-Chlorobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(3-Chlorobenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(3-

Chlorobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 -(3-Chlorobenzyl)-5-chloro-7-methyl- 1H-indole-2,3-dione,1-(3-Chlorobenzyl)-57-dichloro-1H-indole -2,3-dione,1-(3-Chlo

5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected mobenzyl)-1H-indole-2,3-dione

and from its derivatives, for instance 1-(3-Bromobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(3-Bromobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1-(3-Bromobenzyl)-5-trifluorometoxy- 1H-indole-2,3-dione,1-(3-Bromobenzyl)-5-iyodo-1 --indole-2,3-dione,1-(3-Bromobenzyl)-5- nitro-1 7-indole-2,3-dione,1-(3-Bromobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(3-Bromobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3- bromobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3-Bromobenzyl)-2,3-dioxo- 2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3-Bromobenzyl)-7-trifluoromethyl-1 H-indole-2,3- dione,1-(3-Bromobenzyl)-7-metoxy-1 H-indole-2,3-dione,1-(3-Bromobenzyl)-5-fluoro-6-chloro- 1H-indole-2,3-dione,1-(3-Bromobenzyl)-5-chloro-7-methyl-1H-i ndole-2,3-dione,1-(3-

Bromobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(3-Bromobenzyl)-5,7-dibromo-1 H-indole- 2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3-iyodobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3-iyodobenzyl)-5-methyl-1H-indole-2,3-dione,1-(3- lyodobenzyl)-5-(propane-2-yl)-1H-indole-2,3-dione,1-(3-iyodo benzyl)-5-t-butyl-1H-indole-2,3- dione,1-(3-iyodobenzyl)-5-metoxy-1 H-indole-2,3-dione,1-(3-iyodobenzyl)-5-trifluorometoxy- 1H-indole-2,3-dione,1-(3-iyodobenzyl)-5-fluoro-1 --indole-2,3-dione,1-(3-iyodobenzyl)-5- chloro-1 H-indole-2,3-dione,1-(3-iyodobenzyl)-5-bromo-1 --indole-2,3-dione,1-(3- iyodobenzyl)-5-iyodo-1Hindole-2,3-dione,1-(3-iyodobenzyl)-5- nitro-1 H-indole-2,3-dione,1-(3- iyodobenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-carbonitryl, 1 -(3-iyodobenzyl)- 2,3-dioxo-2,3- dihydro-1 --indole-5-carboxamide, Sodium 1 -(3-iyodobenzyl)- 2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 1 -(3-iyodobenzyl)- 2,3-dioxo-2,3-dihydro-1Hindole-5-sulphonamide, 1- (3-iyodobenzyl)-6-fluoro-1H-indole-2,3-dione,1-(3-iyodobenzy l)-6-chloro-1H-indole-2,3- dione,1-(3-iyodobenzyl)-6-bromo-1 --indole-2,3-dione,1-(3-iyodobenzyl)-7-methyl-1 H-indole- 2,3-dione,1-(3-iyodobenzyl)-7-trifluoromethyl-1H-indole-2,3- dione,1-(3-iyodobenzyl)-7- metoxy-1 --indole-2,3-dione,1-(3-iyodobenzyl)-7-fluoro-1 --indole-2,3-dione,1-(3- iyodobenzyl)-7-chloro-1 --indole-2,3-dione,1-(3-iyodobenzyl)-5-fluoro-6-chloro-1 --indole-2,3- dione,1-(3-iyodobenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1-(3-iyodobenzyl)-5,7- dichloro-1 --indole-2,3-dione,1-(3-iyodobenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3-Nitrobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3-Nitrobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(3-Nitrobenzyl)-5-t-butyl-1 --indole-2,3-dione,1-(3-Nitrobenzyl)-5-trifluorometoxy-1 7- indole-2,3-dione,1-(3-Nitrobenzyl)-5-chloro-1 7-indole-2,3-dione,1-(3-Nitrobenzyl)-5-iyodo- 1H-indole-2,3-dione,1-(3-Nitrobenzyl)-2,3-dioxo-2,3-dihydro- 1H-indole-5-carbonitryl, 1-(3- Nitrobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1-(3-nitrobenzyl)-2,3- dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3-Nitrobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole- 5-sulphonamide, 1-(3-Nitrobenzyl)-6-chloro-1 H-indole-2,3-dione,1-(3-Nitrobenzyl)-6-bromo- 1H-indole-2,3-dione,1-(3-Nitrobenzyl)-7-trifluoromethyl-1H-i ndole-2,3-dione,1-(3-Nitrobenzyl)- 7-metoxy-1 H-indole-2,3-dione,1 -(3-Nitrobenzyl)-7-fluoro-1 H-indole-2,3-dione,1 -(3- Nitrobenzyl)-7-chloro-1 --indole-2,3-dione,1-(3-Nitrobenzyl)-7-bromo-1 --indole-2,3-dione,1- (3-Nitrobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione 1 -(3-Nitrobenzyl)-5-chloro-7-methyl-1 H- indole-2,3-dione,1-(3-Nitrobenzyl)-5,7-dichloro-1H-indole-2, 3-dione,1-(3-Nitrobenzyl)-5,7- dibromo-1 H-indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3-Cyanobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3-Cyanobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(3-Cyanobenzyl)-5-t-butyl-1H-indole-2,3-dione,1-(3-C yanobenzyl)-5-metoxy-1H- indole-2,3-dione,1-(3-Cyanobenzyl)-5-trifluorometoxy-1 --indole-2,3-dione,1-(3- Cyanobenzyl)-5-iyodo-1 --indole-2,3-dione,1-(3-Cyanobenzyl)-5-nitro-1 H-indole-2,3-dione,1- (3-Cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(3-Cyanobenzyl)-2,3-dioxo- 2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3-cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 1 -(3-Cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 - (3-Cyanobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1-(3-Cyanobenzyl)-7-metoxy-1 -- indole-2,3-dione,1-(3-Cyanobenzyl)-5-fluoro-6-chloro-1H-indo le-2,3-dione,1-(3-

Cyanobenzyl)-5-chloro-7-methyl-1H-indole-2,3-dione,1-(3-C yanobenzyl)-5,7-dichloro-1 H- indole-2,3-dione,1-(3-Cyanobenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1-(3-Ethylbenzyl)-1H-indole-2,3-dione

and from its derivatives, for instance 1-(3-Ethylbenzyl)-1H-indole-2,3-dione,1-(3-Ethylbenzyl)- 5-methyl-1H-indole-2,3-dione,1-(3-Ethylbenzyl)-5-(propane-2- yl)-1H-indole-2,3-dione,1-(3- Ethylbenzyl)-5-t-butyl-1H-indole-2,3-dione,1-(3-Ethylbenzyl) -5-metoxy-1H-indole-2,3-dione,1- (3-Ethylbenzyl)-5-trifluorometoxy-1 --indole-2,3-dione,1-(3-Ethylbenzyl)-5-fluoro-1 --indole- 2,3-dione,1-(3-Ethylbenzyl)-5-chloro-1H-indole-2,3-dione,1-( 3-Ethylbenzyl)-5-bromo-1H- indole-2,3-dione,1-(3-Ethylbenzyl)-5-iyodo-1H-indole-2,3-dio ne,1-(3-Ethylbenzyl)-5-nitro-1H- indole-2,3-dione,1-(3-Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1H- indole-5-carbonitryl, 1-(3- Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3-ethylbenzyl)-2,3- dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3-Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(3-Ethylbenzyl)-6-fluoro-1 7-indole-2,3-dione,1 -(3-Ethylbenzyl)-6- chloro-1 H-indole-2,3-dione -(3-Ethylbenzyl)-6-bromo-1 H-indole-2,3-dione -(3-Eth

7-methyl-1 H-indole-2,3-dione,1 -(3-Ethylbenzyl)-7-trifluoromethyl-1 H-ind

Ethylbenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(3-Ethylbenzyl)-7-fluoro-1 H-indole-2,3-di (3-Ethylbenzyl)-7-chloro-1 H-indole-2,3-dione,1 -(3-E ^

dione,1 -(3-Ethylbenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 -(3-Ethylbenzyl)-5-chloro-7- methyl-1 H-indole-2,3-dione,1 -(3-Ethylbenzyl)-5,7-dichloro-1 H-indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 1 -[3-(Propane-2-yl)benzyl]-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -[3-(Propane-2-yl)benzyl]-1 H-indole-2,3-dione,1 -[3- (Propane-2-yl)benzyl]-5-methyl-1 H-indole-2,3-dione,1 -[3-(Propane-2-yl)benzyl]-5-(propane-2- yl)-1 H-indole-2,3-dione,1 -[3-(Propane-2-yllbenzyl]-5-t-butyl-1 H-indole-2,3-dione,1 -[3- (Propane-2-yl)benzyl]-5-metoxy-1 H-indole-2,3-dione,1 -[3-(Propane-2-yl)benzyl]-5- trifluorometoxy-1 H-indole-2,3-dione, 1 -[3-(Propane-2-yl)benzyl]-5-fluoro-1 - -indole-2,3- dione,1 -[3-(Propane-2-yl)benzyl]-5-chloro-1 H-indole-2,3-dione,1 -[3-(Propane-2-yl)benzyl]-5- iyodo-1 H-indole-2,3-dione,1 -[3-(Propane-2-yl)benzyl]-5-nitro-1 H-indole-2,3-dione,1 -[3- (Propane-2-yl)benzyl]-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -[3-(Propane-2- yl)benzyl]-2,3-dioxo-2,3-dihydro-1 H-indole-5-carboxamide, Sodium 1 -[3-(propane-2- yl)benzyl]-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -[3-(Propane-2-yl)benzyl]-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -[3-(Propane-2-yl)benzyl]-6-fluoro-1 H-indole- 2,3-dione,1 -[3-(Propane-2-yl)benzyl]-6-chloro-1 H-indole-2,3-dione,1 -[3-(Propane-2- yl)benzyl]-6-bromo-1 H-indole-2,3-dione,1 -[3-(Propane-2-yl)benzyl]-7-methyl-1 H-indole-2,3- dione,1 -[3-(Propane-2-yl)benzyl]-7-trifluoromethyl-1 H-indole-2,3-dione,1 -[3-(Propane-2- yl)benzyl]-7-metoxy-1 - -indole-2,3-dione,1 -[3-(Propane-2-yl)benzyl]-7-fluoro-1 H-indole-2,3- dione,1 -[3-(Propane-2-yl)benzyl]-7-chloro-1 7-indole-2,3-dione,1 -[3-(Propane-2-yl)benzyl]-7- bromo-1 H-indole-2,3-dione,1 -[3-(Propane-2-yl)benzyl]-5-fluoro-6-chloro-1 H-indole-2,3- dione,1 -[3-(Propane-2-yl)benzyl]-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -[3-(Propane-2- yl)benzyl]-5,7-dichloro-1Hindole-2,3-dione,1-[3-(Propane-2-y l)benzyl]^ indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected benzyl)-1H-indole-2,3-dione

and from its derivatives, for instance 1-(3-t-Butylbenzyl)-1H-indole-2,3-dione,1-(3-t- Butylbenzyl)-5-methyl-1 H-indole-2,3-dione,1-(3-t-Butylbenzyl)-5-(propane-2-yl)-1H-i ndole- 2,3-dione,1-(3-t-Butylbenzyl)-5-t-butyl-1H-indole-2,3-dione, 1-(3-t-Butylbenzyl)-5-metoxy-1H- indole-2,3-dione,1-(3-t-Butylbenzyl)-5-trifluorometoxy-1H-in dole-2,3-dione,1-(3-t-

Butylbenzyl)-5 luoro-1H-indole-2,3-dione,1-(3-t-Butylbenzyl)-5-chloro-1H-in dole-2,3-dione,1- (3-t-Butylbenzyl)-5-bromo-1H-indole-2,3-dione,1-(3-t-Butylbe nzyl)-5-iyodo-1H-indole-2,3- dione,1-(3-t-Butylbenzyl)-2,3-dioxo-2,3-dihydro-1H-indole-5- carbonitryl, 1-(3-t-Butylbenzyl)- 2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3-t-butylbenzyl)-2,3-dioxo-2,3- dihydro-1 H-indole-5-sulphonate, 1 -(3-t-Butylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonamide, 1-(3-t-Butylbenzyl)-6-fluoro-1 H-indole-2,3-dione,1-(3-t-Butylbenzyl)-6-chloro- 1H-indole-2,3-dione,1-(3-t-Butylbenzyl)-6-bromo-1H-indole-2, 3-dione,1-(3-t-Butylbenzyl)-7- methyl-1H-indole-2,3-dione,1-(3-t-Butylbenzyl)-7-trifluorome thyl-1H-indole-2,3-dione,1-(3-t- Butylbenzyl)-7-metoxy-1H-indole-2,3-dione,1-(3-t-Butylbenzyl )-7-fluoro-1H-indole-2,3- dione,1-(3-t-Butylbenzyl)-7-chloro-1H-indole-2,3-dione,1-(3- t-Butylbenzyl)-7-bromo-1H- indole-2,3-dione,1-(3-t-Butylbenzyl)-5-fluoro-6-chloro-1H-in dole-2,3-dione,1-(3-t-Butylbenzyl)- 5-chloro-7-methyl-1H-indole-2,3-dione,1-(3-t-Butylbenzyl)-5, 7-dichloro-1H-indole-2,3-dione,1- (3-t-Butylbenzyl)-5,7-dibromo-1H-indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 3-[(2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid

and from its derivatives, for instance 3-[(5-(Propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid,3-[(5-t-Butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(5-Metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(5- Trif luorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(5-Chloro-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(5-Bromo-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)methyl]benzoic acid,3-[(5-iyodo-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid,3-[(5-Nitro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(5-Cyano-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(5-Karbamoil- 2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(5-Cyano-2,3-dioxo-2,3-dihydro- 1 H-indole-1 -yl)methyl]benzoic acid, Sodium 1 -(3-carboxybenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 3-[(5-Sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(6-Chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(6-Bromo-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(7-Methyl-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)methyl]benzoic acid,3-[(7-Trif luoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid,3-[(7-Trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid,3-[(7-Metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 3-[(7-Chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(7-Bromo-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 3-[(5-Fluoro-6-chloro-2,3-dioxo-2,3- dihydro-1 H-indole-1 -yl)methyl]benzoic acid,3-[(5-Chloro-7-methyl-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)methyl]benzoic acid,3-[(5,7-Dichloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid,3-[(5,7-Dibromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid. In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3-Hydroxybenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(3-Hydroxybenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(3-Hydroxybenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(3-Hydroxybenzyl)-5- trifluorometoxy-1 H-indole-2,3-dione, 1 -(3-Hydroxybenzyl)-5-iyodo-1 - -indole-2,3-dione,1 -(3- Hydroxybenzyl)-5-nitro-1 - -indole-2,3-dione,1 -(3-Hydroxybenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carbonitryl, Sodium 1 -(3-hydroxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, 1 -(3-Hydroxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3- Hydroxybenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1 -(3-Hydroxybenzyl)-7-metoxy-1 - - indole-2,3-dione,1 -(3-Hydroxybenzyl)-5-fluoro-6-chloro-1 - -indole-2,3-dione,1 -(3- Hydroxybenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(3-Hydroxybenzyl)-5,7-dichloro-1 H- indole-2,3-dione,1 -(3-Hydroxybenzyl)-5,7-dibromo-1 - -indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected hylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2-Methylbenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(2-Methylbenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(2-Methylbenzyl)-5-iyodo-1 H-indole- 2,3-dione,1 -(2-Methylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2- Methylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(2-methylbenzyl)- 2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2-Methylbenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(2-Methylbenzyl)-7-trif luoromethyl-1 H-indole-2,3-dione,1 -(2-

Methylbenzyl)-7-metoxy-1 - -indole-2,3-dione,1 -(2-Methylbenzyl)-5-fluoro-6-chloro-1 H-indole- 2,3-dione,1 -(2-Methylbenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(2-Methylbenzyl)-5,7- dichloro-1 - -indole-2,3-dione,1 -(2-Methylbenzyl)-5,7-dibromo-1 - -indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2-Trif luoromethylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2-Trifluoromethylbenzyl)-5-(propane-2-yl)-1H-indole- 2,3-dione,1-(2-Trifluoromethylbenzyl)-5-t-butyl-1H-indole-2, 3-dione,1-(2- Trifluoromethylbenzyl)-5-metoxy-1 --indole-2,3-dione,1-(2-Trifluoromethylbenzyl)-5-bromo- 1H-indole-2,3-dione,1-(2-Trifluoromethylbenzyl)-5-iyodo-1 H-indole-2,3-dione,1-(2-

Trifluoromethylbenzyl)-5-nitro-1 H-indole-2,3-dione,1-(2-Trifluoromethylbenzyl)-2,3-dioxo-2,3 - dihydro-1 --indole-5-carbonitryl, 1 -(2-Trifluoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole- 5-carboxamide, Sodium 1 -(2-trifluoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, 1 -(2-Trifluoromethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 - (2-Trifluoromethylbenzyl)-6-fluoro-1 --indole-2,3-dione,1-(2-Trifluoromethylbenzyl)-6-chloro- 1H-indole-2,3-dione,1-(2-Trifluoromethylbenzyl)-6-bromo-1 --indole-2,3-dione,1-(2- Trifluoromethylbenzyl)-7-methyl-1 H-indole-2,3-dione,1-(2-Trifluoromethylbenzyl)-7- trifluoromethyl-1H-indole-2,3-dione,1-(2-Trifluoromethylbenz yl)-7-metoxy-1 H-indole-2,3- dione,1-(2-Trifluoromethylbenzyl)-7-bromo-1 --indole-2,3-dione,1-(2-Trifluoromethylbenzyl)- 5-fluoro-6-chloro-1 H-indole-2,3-dione,1-(2-Trifluoromethylbenzyl)-5-chloro-7-me thyl-1H- indole-2,3-dione,1-(2-Trifluoromethylbenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1-(2- Trifluoromethylbenzyl)-5,7-dibromo-1 --indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1-(2-Metoxybenzyl)-1H-indole-2,3-dione

and from its derivatives, for instance 1-(2-Metoxybenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2-Metoxybenzyl)-5-t-butyl-1 H-indole-2,3-dione,1-(2-Metoxybenzyl)-5-metoxy-1 H- indole-2,3-dione,1-(2-Metoxybenzyl)-5-trifluorometoxy-1 H-indole-2,3-dione,1-(2- Metoxybenzyl)-5-iyodo-1 H-indole-2,3-dione,1-(2-Metoxybenzyl)-5-nitro-1 --indole-2,3- dione,1-(2-Metoxybenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1-(2-Metoxybenzyl)- 2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(2-metoxybenzyl)-2,3-dioxo-2,3- dihydro-1 H-indole-5-sulphonate, 1 -(2-Metoxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonamide, 1 -(2-Metoxybenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1 -(2-Metoxybenzyl)- 7-metoxy-1 H-indole-2,3-dione,1 -(2-Metoxybenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 - (2-Metoxybenzyl)-5,7-dichloro-1 H-indole-2, 3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2-Trif luorometoxybenzyl)-1 H-indole-2, 3-dione

and from its derivatives, for instance 1 -(2-Trifluorometoxybenzyl)-1 H-indole-2, 3-dione, 1 -(2- Trifluorometoxybenzyl)-5-methyl-1 H-indole-2,3-dione,1 -(2-Trifluorometoxybenzyl)-5- (propane-2-yl)-1 H-indole-2,3-dione,1 -(2-Trifluorometoxybenzyl)-5-t-butyl-1 - -indole-2,3- dione,1 -(2-Trifluorometoxybenzyl)-5-metoxy-1 - -indole-2,3-dione,1 -(2- Trifluorometoxybenzyl)-5-trifluorometoxy-1 H-indole-2,3-dione,1 -(2-Trif luorometoxybenzyl)-5- fluoro-1 H-indole-2,3-dione,1 -(2-Trifluorometoxybenzyl)-5-chloro-1 - -indole-2,3-dione,1 -(2- Trifluorometoxybenzyl)-5-bromo-1 H-indole-2, 3-dione, 1 -(2-Trifluorometoxybenzyl)-5-iyodo- 1 H-indole-2, 3-dione, 1 -(2-Trifluorometoxybenzyl)-5-nitro-1 H-indole-2,3-dione,1 -(2- Trifluorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl,1 -(2- Trif luorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, sodium 1 -(2- trifluorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate,1 -(2- Trif luorometoxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2-

Trifluorometoxybenzyl)-6-fluoro-1 H-indole-2, 3-dione,1 -(2-Trif luorometoxybenzyl)-6-chloro- 1 H-indole-2,3-dione,1 -(2-Trif luorometoxybenzyl)-6-bromo-1 - -indole-2,3-dione, 1 -(2- Trifluorometoxybenzyl)-7-methyl-1 H-indole-2, 3-dione,1 -(2-Trif luorometoxybenzyl)-7- trifluoromethyl-1 H-indole-2, 3-dione,1 -(2-Trif luorometoxybenzyl)-7-metoxy-1 H-indole-2, 3- dione,1 -(2-Trifluorometoxybenzyl)-7-fluoro-1 H-indole-2,3-dione,1 -(2-Trifluorometoxybenzyl)- 7-chloro-1 H-indole-2, 3-dione,1 -(2-Trifluorometoxybenzyl)-7-bromo-1 H-indole-2, 3-dione,1 -(2- Trifluorometoxybenzyl)-5-fluoro-6-chloro-1 H-indole-2, 3-dione,1 -(2-Trif luorometoxybenzyl)-5- chloro-7-methyl-1 H-indole-2, 3-dione,1 -(2-Trifluorometoxybenzyl)-5,7-dichloro-1 H-indole-2,3- dione,1 -(2-Trif luorometoxybenzyl)-5,7-dibromo-1 H-indole-2, 3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2-Fluorobenzyl)-1 H-indole-2, 3-dione

and from its derivatives, for instance1 -(2-Fluorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(2-Fluorobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(2-Fluorobenzyl)-5-iyodo-1 - -indole- 2,3-dione,1 -(2-Fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2- Fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5-carboxamide, Sodium 1 -(2-fluorobenzyl)- 2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2-Fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(2-Fluorobenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(2-Fluorobenzyl)- 5-fluoro-6-chloro-1 H-indole-2,3-dione, 1 -(2-Fluorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3- dione,1 -(2-Fluorobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2-Fluorobenzyl)-5,7-dibromo- 1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected obenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2-Chlorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(2-Chlorobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(2-Chlorobenzyl)-5-iyodo-1 - -indole- 2,3-dione,1 -(2-Chlorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2- Chlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(2-chlorobenzyl)- 2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2-Chlorobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(2-Chlorobenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(2-

Chlorobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1 -(2-Chlorobenzyl)-5-chloro-7-methyl- 1 H-indole-2,3-dione,1 -(2-Chlorobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2-Chlorobenzyl)- 5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2-Bromobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2-Bromobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2-Bromobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1-(2-Bromobenzyl)-5-trifluorometoxy- 1H-indole-2,3-dione,1-(2-Bromobenzyl)-5-nitro-1H-indole-2,3- dione,1-(2-Bromobenzyl)-2,3- dioxo-2,3-dihydro-1 Hindole-5-carbonitryl, 1 -(2-Bromobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carboxamide, Sodium 1 -(2-bromobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, 1 -(2-Bromobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2- Bromobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1-(2-Bromobenzyl)-7-metoxy-1 H-indole- 2,3-dione,1-(2-Bromobenzyl)-5-fluoro-6-chloro-1 --indole-2,3-dione,1-(2-Bromobenzyl)-5- chloro-7-methyl-1H-indole-2,3-dione,1-(2-Bromobenzyl)-5,7-di chloro-1 --indole-2,3-dione,1- (2-Bromobenzyl)-5,7-dibromo-1 --indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2-iodobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2-iyodobenzyl)-5-methyl-1H-indole-2,3-dione,1-(2- iyodobenzyl)-5-(propane-2-yl)-1H-indole-2,3-dione,1-(2-iyodo benzyl)-5-t-butyl-1H-indole-2,3- dione,1-(2-iyodobenzyl)-5-metoxy-1 H-indole-2,3-dione,1-(2-iyodobenzyl)-5-trifluorometoxy- 1H-indole-2,3-dione,1-(2-iyodobenzyl)-5-fluoro-1 --indole-2,3-dione,1-(2-iyodobenzyl)-5- chloro-1 H-indole-2,3-dione,1-(2-iyodobenzyl)-5-bromo-1 --indole-2,3-dione,1-(2- iyodobenzyl)-5-iyodo-1 7-indole-2,3-dione,1-(2-iyodobenzyl)-5-nitro-1 H-indole-2,3-dione,1-(2- iyodobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(2-iyodobenzyl)-2,3-dioxo-2,3- dihydro-1 7-indole-5-carboxamide, Sodium 1 -(2-iyodobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 1 -(2-iyodobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 - (2-iyodobenzyl)-6-bromo-1H-indole-2,3-dione,1-(2-iyodobenzyl )-7-methyl-1H-indole-2,3- dione,1-(2-iyodobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1-(2-iyodobenzyl)-7-metoxy- 1H-indole-2,3-dione,1-(2-iyodobenzyl)-7-fluoro-1 --indole-2,3-dione,1-(2-iyodobenzyl)-7- chloro-1 H-indole-2,3-dione -(2-iyodobenzyl)-7-bromo-1Hindole-2,3-dione,1-(2- iyodobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione ,1 -(2-iyodobenzyl)-5-chloro-7-methyl-1 H- indole-2,3-dione -(2-iyodobenzyl)-57-dichloro-1Hindole-2,3-dione,1-(2-iyodobe nzyl)-5,7- dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2-Nitrobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2-Nitrobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2-Nitrobenzyl)-5-t-butyl-1H-indole-2,3-dione,1-(2-N itrobenzyl)-5-trifluorometoxy-1H- indole-2,3-dione,1-(2-Nitrobenzyl)-5-iyodo-1H-indole-2,3-dio ne,1-(2-Nitrobenzyl)-2,3-dioxo- 2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2-Nitrobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- carboxamide, Sodium 1-(2-nitrobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1-(2- Nitrobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2-Nitrobenzyl)-6-chloro-1 H- indole-2,3-dione,1-(2-Nitrobenzyl)-6-bromo-1H-indole-2,3-dio ne,1-(2-Nitrobenzyl)-7- trifluoromethyl-1H-indole-2,3-dione,1-(2-Nitrobenzyl)-7-meto xy-1 H-indole-2,3-dione,1-(2- Nitrobenzyl)-7-fluoro-1H-indole-2,3-dione,1-(2-Nitrobenzyl)- 7-chloro-1H-indole-2,3-dione,1- (2-Nitrobenzyl)-7-bromo-1 --indole-2,3-dione,1-(2-Nitrobenzyl)-5-fluoro-6-chloro-1 --indole- 2,3-dione,1-(2-Nitrobenzyl)-5-chloro-7-methyl-1H-indole-2,3- dione,1-(2-Nitrobenzyl)-5,7- dichloro-1 7-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected obenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2-Cyanobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2-Cyanobenzyl)-5-t-butyl-1 --indole-2,3-dione,1-(2-Cyanobenzyl)-5-metoxy-1 -- indole-2,3-dione,1-(2-Cyanobenzyl)-5-trifluorometoxy-1 --indole-2,3-dione,1-(2- Cyanobenzyl)-5-iyodo-1 7-indole-2,3-dione,1-(2-Cyanobenzyl)-5-nitro-1 H-indole-2,3-dione,1- (2-Cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-carbonitryl, 1 -(2-Cyanobenzyl)-2,3-dioxo- 2,3-dihydro-1 --indole-5-carboxamide, Sodium 1 -(2-cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 1 -(2-Cyanobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 - (2-Cyanobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1-(2-Cyanobenzyl)-7-metoxy-1 -- indole-2,3-dione,1-(2-Cyanobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1-(2-

Cyanobenzyl)-5-chloro-7-methyl-1H-indole-2,3-dione,1-(2-C yanobenzyl)-5,7-dichloro-1 H- indole-2,3-dione,1-(2-Cyanobenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1-(2-Ethylbenzyl)-1H-indole-2,3-dione

and from its derivatives, for instance 1-(2-Ethylbenzyl)-1H-indole-2,3-dione,1-(2-Ethylbenzyl)-

5-methyl-1H-indole-2,3-dione,1-(2-Ethylbenzyl)-5-(propane -2-yl)-1H-indole-2,3-dione,1-(2-

Ethylbenzyl)-5-t-butyl-1H-indole-2,3-dione,1-(2-Ethylbenz yl)-5-metoxy-1H-indole-2,3-dione,1- (2-Ethylbenzyl)-5-trifluorometoxy-1H-indole-2,3-dione,1-(2-E thylbenzyl)-5-fluoro-1H-indole- 2,3-dione,1-(2-Ethylbenzyl)-5-chloro-1H-indole-2,3-dione,1-( 2-Ethylbenzyl)-5-bromo-1H- indole-2,3-dione,1-(2-Ethylbenzyl)-5-iyodo-1H-indole-2,3-dio ne,1-(2-Ethylbenzyl)-5-nitro-1H- indole-2,3-dione,1-(2-Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1H- indole-5-carbonitryl, 1-(2- Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(2-ethylbenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2-Ethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(2-Ethylbenzyl)-6-fluoro-1 H-indole-2,3-dione,1 -(2-Ethylbenzyl)-6- chloro-1H-indole-2,3-dione,1-(2-Ethylbenzyl)-6-bromo-1H-indo le-2,3-dione,1-(2-Ethylbenzyl)- 7-methyl-1H-indole-2,3-dione,1-(2-Ethylbenzyl)-7-trifluorome thyl-1H-indole-2,3-dione,1-(2- Ethylbenzyl)-7-metoxy-1 --indole-2,3-dione,1-(2-Ethylbenzyl)-7-fluoro-1 --indole-2,3-dione,1- (2-Ethylbenzyl)-7-chloro-1H-indole-2,3-dione,1-(2-Ethylbenzy l)-7-bromo-1H-indole-2,3- dione,1-(2-Ethylbenzyl)-5-fluoro-6-chloro-1H-indole-2,3-dion e,1-(2-Ethylbenzyl)-5-chloro-7- methyl-1 H-indole-2,3-dione,1 -(2-Ethylbenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2- Ethylbenzyl)-5.7-dibromo-1 --indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 1 -[2-(Propane-2-yl)benzyl]-1 H-indole-2,3-dione

and from its derivatives, for instance 1-[2-(Propane-2-yl)benzyl]-1H-indole-2,3-dione,1-[2- (Propane-2-yl)benzyl]-5-methyl-1H-indole-2,3-dione,1-[2-(Pro pane-2-yl)benzyl]-5-(propane-2- yl)-1H-indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-5-t-butyl -1H-indole-2,3-dione,1-[2- (Propane-2-yl)benzyl]-5-metoxy-1 --indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-5- trifluorometoxy-1 H-indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-5-fluoro-1 --indole-2,3- dione,1-[2-(Propane-2-yl)benzyl]-5-chloro-1 A7-indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-5- bromo-1 --indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-5-iyodo-1 H-indole-2,3-dione,1-[2- (Propane-2-yl)benzyl]-5-nitro-1H-indole-2,3-dione,1-[2-(Prop ane-2-yl)benzyl]-2,3-dioxo-2,3- dihydro-1H-indole-5-carbonitryl, 1-[2-(Propane-2-yl)benzyl]-2,3-dioxo-2,3-dihydro-1H-indole- 5-carboxamide, Sodium 1 -[2-(propane-2-yl)benzyl]-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, 1-[2-(Propane-2-yl)benzyl]-2,3-dioxo-2,3-dihydro-1H-indole-5 -sulphonamide, 1- [2-(Propane-2-yl)benzyl]-6-fluoro-1H-indole-2,3-dione,1-[2-( Propane-2-yl)benzyl]-6-chloro- 1H-indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-6-bromo-1 --indole-2,3-dione,1-[2-(Propane- 2-yl)benzyl]-7-methyl-1 H-indole-2,3-dione,1 -[2-(Propane-2-yl)benzyl]-7-trifluoromethyl-1 H- indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-7-metoxy-1 7-indole-2,3-dione,1-[2-(Propane-2- yl)benzyl]-7-fluoro-1H-indole-2,3-dione,1-[2-(Propane-2-yl)b enzyl]-7-chloro-1H-indole-2,3- dione,1-[2-(Propane-2-yl)benzyl]-7-bromo-1 --indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-5- fluoro-6-chloro-1 --indole-2,3-dione,1-[2-(Propane-2-yl)benzyl]-5-chloro-7-met hyl-1H-indole- 2,3-dione,1-[2-(Propane-2-yl)benzyl]-5,7-dichloro-1H-indole- 2,3-dione,1-[2-(Propane-2- yl)benzyl]-5,7-dibromo-1 --indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2-t-butylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2-t-butylbenzyl)-1H-indole-2,3-dione,1-(2-t- butylbenzyl)-5-methyl-1Hindole-2,3-dione,1-(2-t-butylbenzyl) -5-(propane-2-yl)-1Hindole-2,3- dione -(2-t-butylbenzyl)-5-t-buty

indole-2,3-dione,1 -(2-t-butylbenzyl)-5-trifluorometoxy-1 H-indole-2,3-dione,1 -(2-t-butylbenzyl)- 5 luoro-1 H-indole-2,3-dione -(2-t-butylbenzyl)-5-chloro-1 H-indole-2,3-dione,1 -(2-t- butylbenzyl)-5-bromo-1 Hindole-2,3-dione,1 -(2-t-butylbenzyl)-5-iyodo-1 H-indole-2,3-dione,1 - (2-t-butylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2-t-butylbenzyl)-2,3-dioxo- 2,3-dihydro-1 Hindole-5-carboxamide, Sodium 1 -(2-t-butylbenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 1 -(2-t-butylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 - (2-t-butylbenzyl)-6-fluoro-1 H-indole-2,3-dione,1 -(2-t-butylbenzyl)-6-chloro-1 H-indole-2,3- dione ,1 -(2-t-butylbenzyl)-6-bromo-1 H-indole-2,3-dione,1 -(2-t-butylbenzyl)-7-methyl-1 H- indole-2,3-dione,1 -(2-t-butylbenzyl)-7-triflu^

7-metoxy-1 H-indole-2,3-dione,1 -(2-t-butylbenzyl)-7-fluoro-1 H-indole-2,3-dione,1 -(2-t- butylbenzyl)-7-chloro-1 Hindole-2,3-dione,1 -(2-t-butylbenzyl)-7-bromo-1 H-indole-2,3-dione,1 - (2-t-butylbenzyl)-5 luoro-6-chloro-1 Hindole-2,3-dione -(2-t-butylbenzyl)-5-chloro-7-methyl^ 1 H-indole-2,3-dione -(2-t-butylbenzyl)-57-dichloro-1 H-indole-2,3-dione -(2-t-butylben 5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected xo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid

and from its derivatives, for instance 2-[(5-Methyl-2,3-dioxo-2,3-dihydro-1 7-indole-1 - yl)methyl]benzoic acid, 2-[(5-(Propane-2-yl)-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid, 2-[(5-t-Butyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(5-Metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(5- Trif luorometoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(5-Fluoro-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(5-Chloro-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)methyl]benzoic acid, 2-[(5-Bromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid, 2-[(5-iyodo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(5-Nitro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(5-Cyano-2,3-dioxo- 2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(5-Karbamoil-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)methyl]benzoic acid, sodium 1 -(2-carboxybenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate,2-[(5-Sulphamoil-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(6-Fluoro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(6-Chloro-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(6-Bromo-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)methyl]benzoic acid, 2-[(7-Methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid, 2-[(7-Trifluoromethyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid, 2-[(7-Metoxy-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(7-Fluoro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(7-Chloro-2,3- dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(7-Bromo-2,3-dioxo-2,3-dihydro-1 H- indole-1 -yl)methyl]benzoic acid, 2-[(5-Fluoro-6-chloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid, 2-[(5-Chloro-7-methyl-2,3-dioxo-2,3-dihydro-1 H-indole-1 - yl)methyl]benzoic acid, 2-[(5,7-Dichloro-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid, 2-[(5,7-Dibromo-2,3-dioxo-2,3-dihydro-1 H-indole-1 -yl)methyl]benzoic acid.

In an application of the present invention, the compounds shown by Formula II are selected oxybenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2-Hydroxybenzyl)-5-methyl-1 H-indole-2,3-dione,1 -(2- Hydroxybenzyl)-5-(propane-2-yl)-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-5-t-butyl-1 H- indole-2,3-dione,1 -(2-Hydroxybenzyl)-5-metoxy-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-5- trifluorometoxy-1 H-indole-2,3-dione, 1 -(2-Hydroxybenzyl)-5-fluoro-1 H-indole-2,3-dione,1 -(2- Hydroxybenzyl)-5-chloro-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-5-bromo-1 H-indole-2,3- dionel -(2-Hydroxybenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-5-nitro-1 H- indole-2,3-dione,1 -(2-Hydroxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2- Hydroxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carboxamide, Sodium 1 -(2- hydroxybenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2-Hydroxybenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2-Hydroxybenzyl)-6-f luoro-1 H-indole-2,3- dione,1 -(2-Hydroxybenzyl)-6-chloro-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-6-bromo-1 H indole-2,3-dione,1 -(2-Hydroxybenzyl)-7-methyl-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-7- trifluoromethyl-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-7-metoxy-1 H-indole-2,3-dione, 1 -(2- Hydroxybenzyl)-7-f luoro-1 H-indole-2,3-dione, 1 -(2-Hydroxybenzyl)-7-chloro-1 H-indole-2,3- dione,1 -(2-Hydroxybenzyl)-7-bromo-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-5-fluoro-6- chloro-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(2- Hydroxybenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2-Hydroxybenzyl)-5,7-dibromo-1 H- indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2,4-Dimethylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2,4-Dimethylbenzyl)-5-methyl-1H-indole-2,3-dione,1- (2,4-Dimethylbenzyl)-5-(propane-2-yl)-1H-indole-2,3-dione,1- (2,4-Dimethylbenzyl)-5-t-butyl- 1H-indole-2,3-dione,1-(2,4-Dimethylbenzyl)-5-metoxy-1H-indol e-2,3-dione,1-(2,4- Dimethylbenzyl)-5-trifluorometoxy-1 --indole-2,3-dione,1-(2,4-Dimethylbenzyl)-5-iyodo-1 -- indole-2,3-dione,1-(2,4-Dimethylbenzyl)-5-nitro-1 --indole-2,3-dione,1-(2,4-Dimethylbenzyl)- 2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2,4-Dimethylbenzyl)-2,3-dioxo-2,3-dihydro- 1H-indole-5-carboxamide, Sodium 1-(2,4-Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, 1 -(2,4-Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,4- Dimethylbenzyl)-6-fluoro-1 H-indole-2,3-dione,1 -(2,4-Dimethylbenzyl)-6-chloro-1 H-indole-2,3- dione,1-(2,4-Dimethylbenzyl)-6-bromo-1 --indole-2,3-dione,1-(2,4-Dimethylbenzyl)-7-methyl- 1H-indole-2,3-dione,1-(2,4-Dimethylbenzyl)-7-trifluoromethyl -1H-indole-2,3-dione,1-(2,4- Dimethylbenzyl)-7-metoxy-1 H-indole-2,3-dione,1-(2,4-Dimethylbenzyl)-7-fluoro-1 --indole- 2,3-dione,1-(2,4-Dimethylbenzyl)-7-chloro-1H-indole-2,3-dion e,1-(2,4-Dimethylbenzyl)-7- bromo-1 --indole-2,3-dione,1-(2,4-Dimethylbenzyl)-5-fluoro-6-chloro- 1 H-indole-2,3-dione,1- (2,4-Dimethylbenzyl)-5-chloro-7-methyl-1H-indole-2,3-dione,1 -(2,4-Dimethylbenzyl)-5,7- dichloro-1 --indole-2,3-dione,1-(2,4-Dimethylbenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2,5-Dimethylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2,5-Dimethylbenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2,5-Dimethylbenzyl)-5-t-butyl-1 H-indole-2,3-dione,1-(2,5-Dimethylbenzyl)-5-metoxy- 1H-indole-2,3-dione,1-(2,5-Dimethylbenzyl)-5-trifluorometoxy -1 7-indole-2,3-dione,1-(2,5- Dimethylbenzyl)-5-iyodo-1 H-indole-2,3-dione,1-(2,5-Dimethylbenzyl)-5-nitro-1 --indole-2,3- dione -(2,5-Dimethylbenzyl)-2,3-dioxo 1 -(2,5- Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5-carboxamide, Sodium 1 -(2,5- Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2,5-Dimethylbenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,5-Dimethylbenzyl)-7-trifluoromethyl-1 H- indole-2,3-dione,1 -(2,5-Dimethylbenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(2,5-

Dimethylbenzyl)-5-fluoro-6-chloro-1 - -indole-2,3-dione, 1 -(2,5-Dimethylbenzyl)-5-chloro-7- methyl-1 H-indole-2,3-dione,1 -(2,5-Dimethylbenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2,5- Dimethylbenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected ethylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2,6-Dimethylbenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(2,6-Dimethylbenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(2,6-Dimethylbenzyl)-5-metoxy- 1 H-indole-2,3-dione,1 -(2,6-Dimethylbenzyl)-5-trifluorometoxy-1 H-indole-2,3-dione,1 -(2,6- Dimethylbenzyl)-5-iyodo-1 H-indole-2,3-dione, 1 -(2,6-Dimethylbenzyl)-5-nitro-1 H-indole-2,3- dione,1 -(2,6-Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-carbonitryl, 1 -(2,6- Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, sodium 1 -(2,6- dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2,6-Dimethylbenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,6-Dimethylbenzyl)-7-trifluoromethyl-1 H- indole-2,3-dione,1 -(2,6-Dimethylbenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(2,6- Dimethylbenzyl)-5-fluoro-6-chloro-1 - -indole-2,3-dione, 1 -(2,6-Dimethylbenzyl)-5-chloro-7- methyl-1 H-indole-2,3-dione,1 -(2,6-Dimethylbenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2,6- Dimethylbenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected f imethylbenzyl)-1 H-indole-2,3-dione

H

and from its derivatives, for instance 1-(3,4-Dimethylbenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(3,4-Dimethylbenzyl)-5-t-butyl-1 H-indole-2,3-dione,1-(3,4-Dimethylbenzyl)-5-metoxy- 1H-indole-2,3-dione,1-(3,4-Dimethylbenzyl)-5-trifluorometoxy -1 7-indole-2,3-dione,1-(3,4- Dimethylbenzyl)-5-nitro-1H-indole-2,3-dione,1-(3,4-Dimethylb enzyl)-2,3-dioxo-2,3-dihydro- 1H-indole-5-carbonitryl, Sodium 1-(3,4-dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5- sulphonate, 1 -(3,4-Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3,4- Dimethylbenzyl)-7-trifluoromethyl-1H-indole-2,3-dione,1-(3,4 -Dimethylbenzyl)-7-metoxy-1 -- indole-2,3-dione,1-(3,4-Dimethylbenzyl)-5-fluoro-6-chloro-1H -indole-2,3-dione,1-(3,4- Dimethylbenzyl)-5-chloro-7-methyl-1H-indole-2,3-dione,1-(3,4 -Dimethylbenzyl)-5,7-dichloro- 1H-indole-2,3-dione,1-(3,4-Dimethylbenzyl)-5,7-dibromo-1H-in dole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected thylbenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3,5-Dimethylbenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1-(3,5-Dimethylbenzyl)-5-t-butyl-1 H-indole-2,3-dione,1-(3,5-Dimethylbenzyl)-5-metoxy- 1H-indole-2,3-dione,1-(3,5-Dimethylbenzyl)-5-trifluorometoxy -1 7-indole-2,3-dione,1-(3,5- Dimethylbenzyl)-5-iyodo-1 H-indole-2,3-dione,1-(3,5-Dimethylbenzyl)-5-nitro-1 --indole-2,3- dione,1-(3,5-Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-carbonitryl, 1 -(3,5- Dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-carboxamide, Sodium 1 -(3,5- dimethylbenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3,5-Dimethylbenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3,5-Dimethylbenzyl)-7-trifluoromethyl-1 H- indole-2,3-dione,1-(3,5-Dimethylbenzyl)-7-metoxy-1 7-indole-2,3-dione,1-(3,5- Dimethylbenzyl)-5-fluoro-6-chloro-1 --indole-2,3-dione,1-(3,5-Dimethylbenzyl)-5-chloro-7- methyl-1H-indole-2,3-dione,1-(3,5-Dimethylbenzyl)-5,7-dichlo ro-1H-indole-2,3-dione,1-(3,5- Dimethylbenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2,3-Difluorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2,3-Difluorobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2,3-Difluorobenzyl)-5-t-butyl-1 --indole-2,3-dione,1-(2,3-Difluorobenzyl)-5-metoxy- 1H-indole-2,3-dione,1-(2,3-Difluorobenzyl)-5-trifluorometoxy -1H-indole-2,3-dione,1-(2,3- Difluorobenzyl)-5-iyodo-1 --indole-2,3-dione,1-(2,3-Difluorobenzyl)-5-nitro-1 --indole-2,3- dione,1-(2,3-Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1H-indole -5-carbonitryl, 1-(2,3- Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(2,3- dif luorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(2,3-Difluorobenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,3-Dif luorobenzyl)-7-trifluoromethyl-1 H- indole-2,3-dione,1-(2,3-Difluorobenzyl)-7-metoxy-1H-indole-2 ,3-dione,1-(2,3-Difluorobenzyl)- 5-fluoro-6-chloro-1H-indole-2,3-dione,1 -(2,3-Dif luorobenzyl)-5-chloro-7-methyl-1H-indole-2,3- dione,1-(2,3-Difluorobenzyl)-5,7-dichloro-1H-indole-2,3-dion e,1-(2,3-Difluorobenzyl)-5,7- dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected fluorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2,4-Difluorobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2,4-Difluorobenzyl)-5-t-butyl-1 --indole-2,3-dione,1-(2,4-Difluorobenzyl)-5-metoxy- 1H-indole-2,3-dione,1-(2,4-Difluorobenzyl)-5-iyodo-1H-indole -2,3-dione,1-(2,4-

Difluorobenzyl)-5-nitro-1H-indole-2,3-dione,1-(2,4-Difluo robenzyl)-2,3-dioxo-2,3-dihydro-1H- indole-5-carbonitryl, 1 -(2,4-Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, sodium 1 -(2,4-dif luorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(2,4- Dif luorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,4-Dif luorobenzyl)-7- trifluoromethyl-1H-indole-2,3-dione,1-(2,4-Difluorobenzyl)-7 -metoxy-1 H-indole-2,3-dione,1- (2,4-Difluorobenzyl)-5-fluoro-6-chloro-1 7-indole-2,3-dione,1 -(2,4-Dif luorobenzyl)-5-chloro-7- methyl-1 H-indole-2,3-dione ,1 -(2,4-Difluorobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2,4- Difluorobenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected robenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2,5-Difluorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(2,5-Difluorobenzyl)-5-t-butyl-1 - -indole-2,3-dione,1 -(2,5-Difluorobenzyl)-5-metoxy-

1 H-indole-2,3-dione,1 -(2,5-Difluorobenzyl)-5-trifluorometoxy-1 - -indole-2,3-dione,1 -(2,5- Difluorobenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(2,5-Difluorobenzyl)-5-nitro-1 H-indole-2,3- dione,1 -(2,5-Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(2,5- Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(2,5- dif luorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(2,5-Difluorobenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,5-Dif luorobenzyl)-7-trifluoromethyl-1 H- indole-2,3-dione,1 -(2,5-Difluorobenzyl)-7-metoxy-1 - -indole-2,3-dione,1 -(2,5-Difluorobenzyl)- 5-fluoro-6-chloro-1 H-indole-2,3-dione, 1 -(2,5-Dif luorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3- dione,1 -(2,5-Difluorobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2,5-Difluorobenzyl)-5,7- dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected orobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2,6-Difluorobenzyl)-5-methyl-1 H-indole-2,3-dione,1 - (2,6-Difluorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3-dione,1 -(2,6-Difluorobenzyl)-5-t-butyl-1 H- indole-2,3-dione,1 -(2,6-Difluorobenzyl)-5-metoxy-1 - -indole-2,3-dione,1 -(2,6-Difluorobenzyl)- 5-bromo-1 H-indole-2,3-dione,1 -(2,6-Difluorobenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(2,6- Difluorobenzyl)-5-nitro-1 H-indole-2,3-dione,1 -(2,6-Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carbonitryl, 1 -(2,6-Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 - -indole-5-carboxamide, Sodium 1 -(2,6-difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2,6- Dif luorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,6-Dif luorobenzyl)-6- fluoro-1 H-indole-2,3-dione,1 -(2,6-Difluorobenzyl)-6-chloro-1 H-indole-2,3-dione,1 -(2,6- Difluorobenzyl)-6-bromo-1 H-indole-2,3-dione, 1 -(2,6-Difluorobenzyl)-7-trifluoromethyl-1 H- indole-2,3-dione,1 -(2,6-Dif luorobenzyl)-7-metoxy-1 - -indole-2,3-dione,1 -(2,6-Dif luorobenzyl)- 7-bromo-1 H-indole-2,3-dione,1 -(2,6-Difluorobenzyl)-5-fluoro-6-chloro-1 - -indole-2,3-dione,1 - (2,6-Difluorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(2,6-Difluorobenzyl)-5,7- dichloro-1 - -indole-2,3-dione,1 -(2,6-Difluorobenzyl)-5,7-dibromo-1 - -indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3,4-Difluorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(3,4-Difluorobenzyl)-5-(propane-2-yl)-1 H-indole-2,3- dione,1 -(3,4-Difluorobenzyl)-5-t-butyl-1 - -indole-2,3-dione,1 -(3,4-Difluorobenzyl)-5-metoxy- 1 H-indole-2,3-dione,1 -(3,4-Difluorobenzyl)-5-trifluorometoxy-1 - -indole-2,3-dione,1 -(3,4- Difluorobenzyl)-5-fluoro-1 H-indole-2,3-dione,1 -(3,4-Difluorobenzyl)-5-iyodo-1 - -indole-2,3- dione,1 -(3,4-Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(3,4- Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3,4- dif luorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3,4-Difluorobenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3,4-Dif luorobenzyl)-7-trifluoromethyl-1 H- indole-2,3-dione,1 -(3,4-Difluorobenzyl)-7-metoxy-1 - -indole-2,3-dione,1 -(3,4-Difluorobenzyl)- 5-fluoro-6-chloro-1 H-indole-2,3-dione, 1 -(3,4-Dif luorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3- dione,1 -(3,4-Difluorobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(3,4-Difluorobenzyl)-5,7- dibromo-1 7-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3,5-Difluorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3,5-Difluorobenzyl)-1H-indole-2,3-dione,1-(3,5- Difluorobenzyl)-5-methyl-1 H-indole-2,3-dione,1 -(3,5-Difluorobenzyl)-5-(propane-2-yl)-1 H- indole-2,3-dione,1-(3,5-Difluorobenzyl)-5-t-butyl-1H-indole- 2,3-dione,1-(3,5-Difluorobenzyl)- 5-metoxy-1 --indole-2,3-dione,1-(3,5-Difluorobenzyl)-5-trifluorometoxy- 1 H-indole-2,3-dione,1- (3,5-Difluorobenzyl)-5-fluoro-1 --indole-2,3-dione,1-(3,5-Difluorobenzyl)-5-chloro-1 H-indole- 2,3-dione,1-(3,5-Difluorobenzyl)-5-iyodo-1 --indole-2,3-dione,1-(3,5-Difluorobenzyl)-5-nitro- 1H-indole-2,3-dione,1-(3,5-Difluorobenzyl)-2,3-dioxo-2,3-dih ydro-1 --indole-5-carbonitryl,1- (3,5-Difluorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, sodium 1 -(3,5- difluorobenzyl)-2,3-dioxo-2,3-dihydro-1H-indole-5-sulphonate ,1-(3,5-Difluorobenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3,5-Difluorobenzyl)-6-fluoro-1 H-indole-2,3- dione,1-(3,5-Difluorobenzyl)-6-chloro-1 --indole-2,3-dione,1-(3,5-Difluorobenzyl)-6-bromo- 1H-indole-2,3-dione,1-(3,5-Difluorobenzyl)-7-methyl-1H-indol e-2,3-dione,1-(3,5- Difluorobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1 -(3,5-Difluorobenzyl)-7-metoxy-1 H- indole-2,3-dione,1-(3,5-Difluorobenzyl)-7-fluoro-1H-indole-2 ,3-dione,1-(3,5-Difluorobenzyl)-7- chloro-1 H-indole-2,3-dione,1-(3,5-Difluorobenzyl)-7-bromo-1 7-indole-2,3-dione,1-(3,5- Difluorobenzyl)-5-fluoro-6-chloro-1 --indole-2,3-dione,1-(3,5-Difluorobenzyl)-5-chloro-7- methyl-1H-indole-2,3-dione,1-(3,5-Difluorobenzyl)-5,7-dichlo ro-1H-indole-2,3-dione,1-(3,5- Difluorobenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2,3-Dichlorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2,3-Dichlorobenzyl)-1H-indole-2,3-dione,1-(2,3- Dichlorobenzyl)-5-methyl-1 H-indole-2,3-dione,1 -(2,3-Dichlorobenzyl)-5-(propane-2-yl)-1 H- indole-2,3-dione,1-(2,3-Dichlorobenzyl)-5-t-butyl-1H-indole- 2,3-dione,1-(2,3-Dichlorobenzyl)- 5-metoxy-1 H-indole-2,3-dione,1 -(2,3-Dichlorobenzyl)-5-trifluorometoxy-1 H-indole-2,3- dione,1-(2,3-Dichlorobenzyl)-5-fluoro-1 H-indole-2,3-dione,1-(2,3-Dichlorobenzyl)-5-chloro- 1H-indole-2,3-dione,1-(2,3-Dichlorobenzyl)-5-bromo-1H-indole -2,3-dione,1-(2,3- Dichlorobenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(2,3-Dichlorobenzyl)-5-nitro-1 H-indole-2,3- dione,1-(2,3-Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1H-indole -5-carbonitryl, 1-(2,3- Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-carboxamide, Sodium 1 -(2,3- dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1-(2,3-Dichlorobenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1-(2,3-Dichlorobenzyl)-6-bromo-1 --indole-2,3- dione,1-(2,3-Dichlorobenzyl)-7-methyl-1H-indole-2,3-dione,1- (2,3-Dichlorobenzyl)-7- trifluoromethyl-1H-indole-2,3-dione,1-(2,3-Dichlorobenzyl)-7 -m

(2,3-Dichlorobenzyl)-7-fluoro-1 H-indole-2,3-dione,1 -(2,3-Dichlorobenzyl)-7-chloro-1 H-indole- 2,3-dione,1-(2,3-Dichlorobenzyl)-7-bromo-1H-indole-2,3-dione ,1-(2,3-Dichlorobenzyl)-5- fluoro-6-chloro-1 --indole-2,3-dione,1-(2,3-Dichlorobenzyl)-5-chloro-7-methyl- 1 H-indole-2,3- dione,1-(2,3-Dichlorobenzyl)-5,7-dichloro-1H-indole-2,3-dion e,1-(2,3-Dichlorobenzyl^ dibromo-1 H-indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected ichlorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2,4-Dichlorobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2,4-Dichlorobenzyl)-5-t-butyl-1 --indole-2,3-dione,1-(2,4-Dichlorobenzyl)-5-metoxy- 1H-indole-2,3-dione,1-(2,4-Dichlorobenzyl)-5-trifluorometoxy -1H-indole-2,3-dione,1-(2,4-

Dikorobenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(2,4-Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carbonitryl, 1 -(2,4-Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium1-(2,4-dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1-(2,4- Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1-(2,4-Dichlorobenzyl)-7- trifluoromethyl-1H-indole-2,3-dione,1-(2,4-Dichlorobenzyl)-7 -metoxy-1 --indole-2,3-dione,1- (2,4-Dichlorobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1-(2,4-Dichlorobenzyl)-5-chloro-7- methyl-1H-indole-2,3-dione,1-(2,4-Dichlorobenzyl)-5,7-chloro -1H-indole-2,3-dione,1-(2,4- Dichlorobenzyl)-5,7-dibromo-1 --indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2,6-Dichlorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2,6-Dichlorobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(2,6-Dichlorobenzyl)-5-t-butyl-1 --indole-2,3-dione,1-(2,6-Dichlorobenzyl)-5-metoxy- 1H-indole-2,3-dione,1-(2,6-Dichlorobenzyl)-5-trifluorometoxy -1H-indole-2,3-dione,1-(2,6- Dichlorobenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(2,6-Dichlorobenzyl)-5-nitro-1 H-indole-2,3- dione,1-(2,6-Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1H-indole -5-carbonitryl,1-(2,6- Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, sodium 1 -(2,6- dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-sulphonate,1-(2,6-Dichlorobenzyl)-2,3- dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,6-Dichlorobenzyl)-7-trifluoromethyl-1 H- indole-2,3-dione,1-(2,6-Dichlorobenzyl)-7-metoxy-1H-indole-2 ,3-dione,1-(2,6-

Dichlorobenzyl)-5-fluoro-6-chloro-1 --indole-2,3-dione,1-(2,6-Dichlorobenzyl)-5-chloro-7- methyl-1H-indole-2,3-dione,1-(2,6-Dichlorobenzyl)-5,7-dichlo ro-1H-indole-2,3-dione,1-(2,6-

Dichlorobenzyl)-5,7-dibromo-1 --indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3,4-Dichlorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3,4-Dichlorobenzyl)-5-(propane-2-yl)-1H-indole-2,3- dione,1-(3,4-Dichlorobenzyl)-5-t-butyl-1H-indole-2,3-dione,1 -(3,4-Dichlorobenzyl)-5- trifluorometoxy-1 H-indole-2,3-dione,1-(3,4-Dichlorobenzyl)-5-iyodo-1 --indole-2,3-dione,1- (3,4-Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1-(3,4-Dichlorobenzyl)- 2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3,4-dichlorobenzyl)-2,3-dioxo- 2,3-dihydro-1 7-indole-5-sulphonate, 1-(3,4-Dichlorobenzyl)-7-metoxy-1 --indole-2,3-dione,1- (3,4-Dichlorobenzyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1-(3,4-Dichlorobenzyl)-5,7- dichloro-1 --indole-2,3-dione,1-(3,4-Dichlorobenzyl)-5,7-dibromo-1 --indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected hlorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(3,5-Dichlorobenzyl)-5-methyl-1H-indole-2,3-dione,1- (3,5-Dichlorobenzyl)-5-(propane-2-yl)-1H-indole-2,3-dione,1- (3,5-Dichlorobenzyl)-5-t-butyl- 1H-indole-2,3-dione,1-(3,5-Dichlorobenzyl)-5-metoxy-1 7-indole-2,3-dione,1-(3,5- Dichlorobenzyl)-5-trifluorometoxy-1 H-indole-2,3-dione,1 -(3,5-Dichlorobenzyl)-5-fluoro-1 7- indole-2,3-dione,1-(3,5-Dichlorobenzyl)-5-chloro-1 --indole-2,3-dione,1-(3,5-Dichlorobenzyl)- 5-bromo-1 H-indole-2,3-dione,1-(3,5-Dichlorobenzyl)-5-iyodo-1 --indole-2,3-dione,1-(3,5- Dichlorobenzyl)-5-nitro-1H-indole-2,3-dione,1-(3,5-Dichlorob enzyl)-2,3-dioxo-2,3-dihydro-1H- indole-5-carbonitryl, 1 -(3,5-Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(3,5-dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 -(3,5- Dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1-(3,5-Dichlorobenzyl)-6- fluoro-1H-indole-2,3-dione,1-(3,5-Dichlorobenzyl)-6-chloro-1 H-indole-2,3-dione,1-(3,5- Dichlorobenzyl)-6-bromo-1H-indole-2,3-dione,1-(3,5-Dichlorob enzyl)-7-methyl-1H-indole-2,3- dione,1-(3,5-Dichlorobenzyl)-7-trifluoromethyl-1H-indole-2,3 -dione,1-(3,5-Dichlorobenzyl)-7- metoxy-1 --indole-2,3-dione,1-(3,5-Dichlorobenzyl)-7-fluoro-1 --indole-2,3-dione,1-(3,5- Dichlorobenzyl)-7-chloro-1 H-indole-2,3-dione,1-(3,5-Dichlorobenzyl)-7-bromo-1 --indole-2,3- dione,1-(3,5-Dichlorobenzyl)-5-fluoro-6-chloro-1 --indole-2,3-dione,1-(3,5-Dichlorobenzyl)-5- chloro-7-methyl-1H-indole-2,3-dione,1-(3,5-Dichlorobenzyl)-5 ,7-dichloro-1H-indole-2,3- dione,1 -(3,5-Dichlorobenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(2-Chloro-4-fluorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(2-Chloro-4-fluorobenzyl)-5-(propane-2-yl)-1H-indole- 2,3-dione,1-(2-Chloro-4-fluorobenzyl)-5-t-butyl-1H-indole-2, 3-dione,1-(2-Chloro-4- fluorobenzyl)-5-metoxy-1 Hindole-2,3-dio^

1 H-indole-2,3-dione,1 -(2-Chloro-4-fluorobenzyl)-5-nitro-1 H-indole-2,3-dion^

fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 Hindole-5-carbonitryl, 1 -(2-Chloro-4-fluorobenzyl)-2,3- dioxo-2,3-dihydro-1 - -indole-5-carboxamide, Sodium 1 -(2-chloro-4-fluorobenzyl)-2,3-dioxo- 2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2-Chloro-4-fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(2-Chloro-4-fluorobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1 - (2-Chloro-4-fluorobenzyl)-7-metoxy-1 -/-indole-2,3-dione,1 -(2-Chloro-4-fluorobenzyl)-5-fluoro- 6-chloro-1 H-indole-2,3-dione,1 -(2-Chloro-4-fluorobenzyl)-5-chloro-7-methyl-1 H

dione,1 -(2-Chloro-4-fluorobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2-Chloro-4- fluorobenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected oro-6-fluorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2-Chloro-6-fluorobenzyl)-5-(propane-2-yl)-1 H-indole- 2,3-dione,1 -(2-Chloro-6-fluorobenzyl)-5-t-butyl-1 H-indole-2,3-dione,1 -(2-Chloro-6- fluorobenzyl)-5-metoxy-1 - -indole-2,3-dione,1 -(2-Chloro-6-fluorobenzyl)-5-trifluorometoxy- 1 H-indole-2,3-dione,1 -(2-Chloro-6-fluorobenzyl)-5-iyodo-1 H-indole-2,3-dione,1 -(2-Chloro-6- fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1 -(2-Chloro-6-fluorobenzyl)-2,3- dioxo-2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(2-chloro-6-fluorobenzyl)-2,3-dioxo- 2,3-dihydro-1 H-indole-5-sulphonate, 1 -(2-Chloro-6-fluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonamide, 1 -(2-Chloro-6-fluorobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1 - (2-Chloro-6-fluorobenzyl)-7-metoxy-1 - -indole-2,3-dione,1 -(2-Chloro-6-fluorobenzyl)-5-fluoro- 6-chloro-1 H-indole-2,3-dione,1 -(2-Chloro-6-fluorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3- dione,1 -(2-Chloro-6-fluorobenzyl)-5,7-dichloro-1 H-indole-2,3-dione,1 -(2-Chloro-6- fluorobenzyl)-5,7-dibromo-1 - -indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -(3,4,5-Trif luorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(3,4,5-Trifluorobenzyl)-5-methyl-1 /-/-indole-2,3- dione,1 -(3,4,5-Trifluorobenzyl)-5-(propane-2-yl)-1 /-/-indole-2,3-dione,1 -(3,4,5- Trifluorobenzyl)-5-t-butyl-1 /-/-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-5-metoxy-1 H-indole- 2,3-dione,1 -(3,4,5-Trifluorobenzyl)-5-trifluorometoxy-1 7-indole-2,3-dione,1 -(3,4,5-

Trifluorobenzyl)-5-fluoro-1 - -indole-2,3-dione,1 -(3,4, 5-Trifluorobenzyl)-5-chloro-1 /-/-indole- 2,3-dione,1 -(3,4,5-Trifluorobenzyl)-5-bromo-1 /-/-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-5- iyodo-1 /7-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-2,3-dioxo-2,3-dihydro-1 /-/-indole-5- carbonitryl, 1 -(3,4,5-Trifluorobenzyl)-2,3-dioxo-2,3-dihydro-1 /7-indole-5-carboxamide, Sodium 1 -(3,4,5-trifluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonate, 1 -(3,4,5-

Trifluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(3,4,5-Trifluorobenzyl)-6- fluoro-1 H-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-6-chloro-1 H-indole-2,3-dione,1 -(3,4,5- Trifluorobenzyl)-6-bromo-1 /7-indole-2,3-dione,1 -(3,4, 5-Trifluorobenzyl)-7-methyl-1 /-/-indole- 2,3-dione,1 -(3,4,5-Trifluorobenzyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1 -(3,4,5- Trifluorobenzyl)-7-metoxy-1 H-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-7-fluoro-1 /-/-indole- 2,3-dione,1 -(3,4,5-Trifluorobenzyl)-7-chloro-1 H-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-7- bromo-1 /-/-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-5-fluoro-6-chloro-1 /-/-indole-2,3-dione,1 - (3,4,5-Trifluorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-5,7- dichloro-1 /-/-indole-2,3-dione,1 -(3,4,5-Trifluorobenzyl)-5,7-dibromo-1 H-indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected

6-Pentafluorobenzyl)-1 H-indole-2,3-dione

and from its derivatives, for instance 1 -(2,3,4,5,6-Pentafluorobenzyl)-5-methyl-1 H-indole-2,3- dione,1 -(2,3,4,5,6-Pentafluorobenzyl)-5-(propane-2-yl)-1 Hindole-2,3-dione,1 -(2,3,4,5,6- Pentafluorobenzyl)-5-t-butyl-1 /-/-indole-2,3-dione,1 -(2,3,4,5,6-Pentafluorobenzyl)-5-metoxy- 1 /-/-indole-2,3-dione,1 -(2,3,4,5,6-Pentafluorobenzyl)-5-trifluorometoxy-1 /7-indole-2,3-dione,1 - (2,3,4,5,6-Pentafluorobenzyl)-5-fluoro-1H-indole-2,3-dione,1 -(2,3,4,5,6-Pentafluorobenzyl)-5- chloro-1 H-indole-2,3-dione -(2,3,4,5,6-Pentafluorobenzyl)-5-bromo-1 --indole-2,3-dione,1- (2,3,4,5,6-Pentafluorobenzyl)-5-iyodo-1H-indole-2,3-dione,1- (2,3,4,5,6-Pentafluorobenzyl)-5- nitro-1H-indole-2,3-dione,1-(2,3,4,5,6-Pentafluorobenzyl)-2, 3-dioxo-2,3-dihydro-1H-in carbonitryl, 1 -(2,3,4,5,6-Pentafluorobenzyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-carboxamide, Sodium 1 -(2,3,4,5,6-pentaf luorobenzyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-sulphonate, 1 - (2,3,4,5,6-Pentafluorobenzyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(2,3,4,5,6- Pentafluorobenzyl)-6-fluoro-1H-indole-2,3-dione,1-(2,3,4,5,6 -Pentafluorobenzyl)-6-chloro-1H- indole-2,3-dione,1-(2,3,4,5,6-Pentafluorobenzyl)-6-bromo-1H- indole-2,3-dione,1 -(2,3,4,5,6- Pentafluorobenzyl)-7-methyl-1 H-indole-2,3-dione,1 -(2,3,4,5,6-Pentafluorobenzyl)-7- trifluoromethyl-1H-indole-2,3-dione,1-(2,3,4,5,6-Pentafluoro benzyl)-7-metoxy-1 H-indole-2,3- dione,1-(2,3,4,5,6-Pentafluorobenzyl)-7-fluoro-1H-indole-2,3 -dione,1-(2,3, 4,5,6- Pentafluorobenzyl)-7-chloro-1 --indole-2,3-dione,1-(2,3,4,5,6-Pentafluorobenzyl)-7-bromo- 1H-indole-2,3-dione,1-(2,3,4,5,6-Pentafluorobenzyl)-5-fluoro -6-chloro-1H-indole-2,3-dione,1- (2,3,4,5,6-Pentafluorobenzyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1 -(2,3,4,5,6- Pentafluorobenzyl)-5,7-dichloro-1 --indole-2,3-dione.

In an application of the present invention, the compounds shown by Formula II are selected from 1 -Naphtylmethyl-1 H-indole-2,3-dione

and from its derivatives, for instance 1-(1-naphtylmethyl)-5-methyl-1H-indole-2,3-dione,1-(1- naphtylmethyl)-5-(propane-2-yl)-1H-indole-2,3-dione,1-(1-nap htylmethyl)-5-t-butyl-1H-indole- 2,3-dione,1-(1-naphtylmethyl)-5-metoxy-1 --indole-2,3-dione,1-(1-naphtylmethyl)-5- trifluorometoxy-1 H-indole-2,3-dione, 1 -(1 -naphtylmethyl)-5-fluoro-1 H-indole-2,3-dione,1 -(1 - naphtylmethyl)-2,3-dioxo-2,3-dihydro-1 7-indole-5-carbonitryl, 1-(1-naphtylmethyl)-2,3-dioxo- 2,3-dihydro-1 7-indole-5-carboxamide, Sodium 1 -(1 -naphtylmethyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-sulphonate, 1 -(1 -naphtylmethyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5-sulphonamide, 1 -(1 -naphtylmethyl)-6-fluoro-1 H-indole-2,3-dione,1 -(1 -naphtylmethyl)-6-chloro-1 H-indole-2,3- dione,1 -(1 -naphtylmethyl)-6-bromo-1 H-indole-2,3-dione,1 -(1 -naphtylmethyl)-7-methyl-1 H- indole-2,3-dione,1-(1-naphtylmethyl)-7-trifluoromethyl-1 H-indole-2,3-dione,1-(1- naphtylmethyl)-7-metoxy-1 --indole-2,3-dione,1-(1-naphtylmethyl)-7-fluoro-1 --indole-2,3- dione,1-(1-naphtylmethyl)-7-chloro-1 --indole-2,3-dione,1-(1-naphtylmethyl)-7-bromo-1 -- indole-2,3-dione,1-(1-naphtylmethyl)-5-fluoro-6-chloro-1 H-indole-2,3-dione,1-(1- naphtylmethyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1-(1-naphtylmethyl)-5,7-dichloro-1 -- indole-2,3-dione. In an application of the present invention, the compounds shown by Formula II are selected from 2-Na H-indole-2,3-dione

and from its derivatives, for instance 1-(2-naphtylmethyl)-5-methyl-1H-indole-2,3-dione,1-(2- naphtylmethyl)-5-(propane-2-yl)-1H-indole-2,3-dione,1-(2-nap htylmethyl)-5-t-butyl-1H-indole- 2,3-dione,1-(2-naphtylmethyl)-5-metoxy-1H-indole-2,3-dione,1 -(2-naphtylmethyl)-5- trifluorometoxy-1 H-indole-2,3-dione,1-(2-naphtylmethyl)-5-fluoro-1 --indole-2,3-dione,1-(2- naphtylmethyl)-5-nitro-1 H-indole-2,3-dione,1 -(2-naphtylmethyl)-2,3-dioxo-2,3-dihydro-1 H- indole-5-carbonitryl, Sodium 1 -(2-naphtylmethyl)-2,3-dioxo-2,3-dihydro-1 H-indole-5- sulphonate, 1-(2-naphtylmethyl)-2,3-dioxo-2,3-dihydro-1 --indole-5-sulphonamide, 1-(2- naphtylmethyl)-6-fluoro-1H-indole-2,3-dione,1-(2-naphtylmeth yl)-6-chloro-1H-indole-2,3- dione,1-(2-naphtylmethyl)-6-bromo-1 H-indole-2,3-dione,1-(2-naphtylmethyl)-7-methyl-1 H- indole-2,3-dione,1-(2-naphtylmethyl)-7-trifluoromethyl-1H-in dole-2,3-dione,1-(2- naphtylmethyl)-7-metoxy-1 --indole-2,3-dione,1-(2-naphtylmethyl)-7-fluoro-1 --indole-2,3- dione,1-(2-naphtylmethyl)-7-chloro-1 --indole-2,3-dione,1-(2-naphtylmethyl)-7-bromo-1 H- indole-2,3-dione,1-(2-naphtylmethyl)-5-fluoro-6-chloro-1H-in dole-2,3-dione,1-(2- naphtylmethyl)-5-chloro-7-methyl-1 H-indole-2,3-dione,1-(2-naphtylmethyl)-5,7-dichloro-1 -- indole-2,3-dione.

From another perspective, the present invention relates to 2-indolinon derivative molecules whose general chemical structure is shown by Formula III:

. Re

^■ 4 ϊϊϊ \

Rv In Formula III;

is hydrogen, alkyl, metoxy, trifluorometoxy, halogen, nitro, carbonitryl, carboxamide, sodium sulphonate, sulphonamide. F>2 represents hydrogen, halogen.

R ₃ represents hydrogen, alkyl, trifluoromethyl, metoxy, halogen.

R ₄ represents hydrogen, alkyl, alkenil, aralkyl, alkanoic acid, alkanoic acid alkyl ester.

R ₅ , R ₆ and R ₇ represent sulphonamide in an independent manner. In Formula III,

The alkyl substituent in R^ defines methyl, isopropyl and tersiyer butyl groups.

The halogen in R^ is fluor, chlor, bromine and iodine.

The halogen in R ₂ is fluor, chlor and bromine. The halogen in R ₃ represents fluor, chlor and bromine.

In a preferred application of the present invention, in R _{1 :} fluor groups are defined and in R ₂ , chlor groups are defined, in R _{1 :} chlor groups are defined and in R ₃ , methyl groups are defined, in R^ and R ₃ , dichlor groups are defined, in R^ and R ₃ , dibromine groups are defined.

R ₄ represents saturated or unsaturated, branched or unbranched Ci_ ₃ alkyl, branched or unbranched C ₂ . ₄ alkanoic acid, C ₂ . ₄ branched or unbranched alkanoic acid, branched or unbranched C ₂ . ₄ alkyl ester.

In R ₄ , as saturated or unsaturated, branched or unbranched Ci_ ₃ alkyl, methyl, ethyl, n- propyl, isopropyl and allyl are defined.

In R ₄ , branched or unbranched C ₂ . ₄ alkanoic acid is represented by acetic acid, 2- methylacetic acid, propanonic acid, butanoic acid. In R ₄ , branched or unbranched C ₂ . ₄ alkyl ester of the C ₂ . ₄ branched or unbranched alkanoic acid is represented by ethyl acetate, isopropyl acetate, tersiyer butyl acetate, ethyl propanoate, ethyl 2-methylacetate, ethyl butanoate. In R ₄ , substituted benzyl carries Ci_ ₄ straight or branched alkyl, trifluoromethyl, metoxy, trifluorometoxy, fluor, chlor, bromine, iodine, nitro, carbonitryl, carboxy, hydroxy groups in positions 2, 3 or 4 of the phenyl ring. Here, Ci_ ₄ straight or branched alkyl defines methyl, ethyl, isopropyl and tersiyer butyl groups. Substituted benzyl moreover carries 2,4-dimethyl, 2,5-dimethyl, 2,6-dimethyl, 3,4-dimethyl, 3,5-dimethyl, 2,3-difluor, 2,4-difluor, 2,5-difluor, 2,6- difluor, 3,4-difluor, 3,5-difluor, 2,4-dichlor, 2,6-dichlor, 3,4-dichlor, 3,5-dichlor, 2-chlor-4-fluor, 2-chlor-6-fluor, 3,4,5-trifluor, 2,3,4,5,6-pentafluor in the phenyl ring.

In the sulphonamide benzene ring in R ₅ , R ₆ and R ₇ , when it is placed in R ₅ , hydrogen is provided in R ₆ and R ₇ , when it is placed in R ₆ , hydrogen is provided in R ₅ and R ₇ , and when it is placed in R ₇ , hydrogen is provided in R ₅ and R ₆ .

The general chemical name of the compounds shown by Formula III is 2-(2-oxo-1 ,2-dihydro- 3 - -indole-3-yliden)-/V-(2/3/4-sulphamoilphenyl)hydrazine carbothioamide derivatives. In order to generally describe these molecules within the scope of the present invention, "Formula III" and/or "2-(2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2/3/4 sulphamoilphenyl) hydrazine carbothioamide" and/or 1 H-indole-2,3-dione 3-/V-(2/3/4-sulphamoilphenyl) thiosemi-carbazone terms can be interchangeably used.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(2-sulphamoilphenyl) hydrazine- carbothioamide

and from its derivatives, for instance 2-[5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3- yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-(5-t-butyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(5-metoxy-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(5-iyodo-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(5- cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl) hydrazinecarbothio- amide, 2-(5-karbamoil-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl) hydrazinecarbothioamide, Sodium 3-[2-oxo-3-[2-(sulphamoilphenyl)karbamotioil]hydrazine- yliden]-2,3-dihydro-1 7-indole-5-sulphonate, 2-(5-sulphamoil-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-(6-fluoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(6-chloro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(6-bromo-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(7- methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)

hydrazinecarbothioamide, 2-(7-trifluoromethyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(7-metoxy-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-(7-fluoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(7-chloro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl) hydrazinecarbothioamide, 2-(7-bromo-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(5- fluoro-6-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)

hydrazinecarbothioamide, 2-(5-chloro-7-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(5,7-dichloro-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1-Methyl-2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(2-sulphamoilphenyl) hydrazinecarbothioamide and from its derivatives, for instance 2-(1 -methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 ,5-dimethyl-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -methyl-5-(propane-2-yl)-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-f luoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-2-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -methyl-5-chloro-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-5-bromo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl) hydrazinecarbothioamide, 2-(1 -methyl-5-iyodo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl) hydrazinecarbothioamide, 2-(1 -methyl-5-nitro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-5-cyano-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-5-karbamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, Sodium 3-[1 -methyl-2-oxo-3-[2-

(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihyd ro-1 7-indole-5-sulphonate, 2-(1 - methyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-6-f luoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-6-chloro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-6-bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-7-fluoro-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-bromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-5-fluoro-6- chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-chloro-7-methyl-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -methyl- 5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5,7-dibromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1-Ethyl-2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(2-sulphamoilphenyl) hydrazinecarbothioamide

and from its derivatives, for instance 2-(1 -ethyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-[1 -ethyl-5-(propane-2- yl)-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -ethyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-fluoro-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-chloro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-5- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-iyodo-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-nitro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-5- cyano-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-karbamoil-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, Sodium 3-[1 -ethyl-2-oxo-3- [2-(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihyd ro-1 7-indole-5-sulphonate, 2-(1 - ethyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-6-fluoro-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-6-chloro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-6- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -ethyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -ethyl-7-fluoro-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-bromo-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-fluoro-6-chloro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - ethyl-5-chloro-7-methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5,7-dichloro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(2-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -ethyl-5,7-dibromo-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(2-sulphamoilph

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1 -Allyl-2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(2-sulphamoilphenyl) e

and from its derivatives, for instance 2-[1 -(2-propenyl)-2-oxo-1 ,2-dihydro-3 7-indole-3-yliden]- /V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-propenyl)-5-methyl-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide,2-[1 -(2- propenyl)-5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-propenyl)-5-t-butyl-2-oxo-1 ,2-dihydro- 3H-indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothi oamide, 2-[1 -(2-propenyl)-5- metoxy-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-propenyl)-5-trif luorometoxy-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- propenyl)-5-fluoro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-propenyl)-5-chloro-2-oxo-1 ,2-dihydro- 3H-indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothi oamide, 2-[1 -(2-propenyl)-5- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-propenyl)-5-iyodo-2-oxo-1 ,2-dihydro-3H- indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-[1 -(2-propenyl)-5-nitro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 - (2-propenyl)-5-cyano-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-propenyl)-5-karbamoil-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, Sodium 3-[1 - (2-propenyl)-2-oxo-3-[2-(sulphamoilphenyl)karbamotioil]hydra zineiliden]-2,3-dihydro-1 H- indole-5-sulphonate, 2-[1 -(2-propenyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V- (2-sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(2-propenyl)-6-fluoro-2-oxo-1 ,2-dihydro- 3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2-propenyl)-6- chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(2-propenyl)-6-bromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide,2-[1 -(2-propenyl)-7-methyl- 2-0X0-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarboth

(2-propenyl)-7-trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/\/-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(2-propenyl)-7-metoxy-2-oxo-1 ,2-dihydro- 3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinecarbothio am

fluoro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(2-propenyl)-7-chloro-2-oxo-1 ,2-dihydro-3H indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinecarbothioam

2-0X0-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilph

(2-propenyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(2-propenyl)-5-chloro-7-methyl-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioamid

propenyl)-5,7-dichloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(2-propenyl)-5J-dibromo-2-oxo-1 ,2-dihydro- 3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinecarbothioa mide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H- indole-1-aceticacid

and from its derivatives, for instance 2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 - -indole-1 -aceticacid,5-methyl- 2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid,5-(propane-2-yl)-2-oxo-3-[2-[(2-sulphamoilphenyl) karbamotioil]hydrazineiliden]- 2,3-dihydro-1 H-indole-1 -aceticacid,5-t-butyl-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 - -indole-1 -aceticacid,5-metoxy- 2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid,5-trifluorometoxy-2-oxo-3-[2-[(2-sulphamoilphenyl )karbamotioil]hydrazineiliden]- 2,3-dihydro-1 Hindole-1 -aceticacid,5-f luoro-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 - -indole-1 -aceticacid,5-chloro- 2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid,5-bromo-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamoti oil]hydrazineiliden]-2,3- dihydro-1 H-indole-1 -aceticacid,5-iyodo-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid,5-cyano- 2-oxo-3-[2-[(2-sulphamoilphenyl)karbamoti H-indole-1 - aceticacid,5-karbamoil-2-oxo-3-[2-[(2-sulph

dihydro-1 H-indole-1 -aceticacid, sodium 1 -(carboxymethyl)-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 Hindole-5-sulphon

2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineili den]-2,3-dihydro-1 H-indole-1 - aceticacid, 6-chloro-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2, 3- dihydro-1 H-indole-1 -aceticacid, 6-bromo-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 7-methyl- 2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid, 7-trifluoromethyl-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotio il]hydrazineiliden]- 2,3-dihydro-1 H-indole-1 -aceticacid, 7-metoxy-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 7-fluoro-2- oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineiliden]- 2,3-dihydro-1 H-indole-1 - aceticacid, 7-chloro-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2, 3- dihydro-1 H-indole-1 -aceticacid, 7-bromo-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 7-fluoro-2- oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineiliden]- 2,3-dihydro-1 H-indole-1 - aceticacid, 5-fluoro-6-chloro-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotio il]hydrazineiliden]- 2,3-dihydro-1 H-indole-1 -aceticacid, 5-chloro-7-methyl-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 5,7- dichloro-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2,3-dihydro-1 H-indole- 1 -aceticacid, 5, 7-dibromo-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydra zineiliden]-2, 3- dihydro-1 H-indole-1 -aceticacid. In an application of the present invention, the compounds shown by Formula III are selected from ethyl 2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro- 1 H-indole-1 -acetate

and from its derivatives, for instance ethyl 2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, Ethyl 5- methyl-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazin eiliden]-2,3-dihydro-1 H-indole- 1 -acetate, ethyl 5-(propane-2-yl)-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, ethyl 5-t- butyl-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazine iliden]-2,3-di acetate, ethyl 5-metoxy-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2,3- dihydro-1 H-indole-1 -acetate, ethyl 5-trif luorometoxy-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, ethyl 5- fluoro-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazin eiliden]-2,3-dihydro-1 - -indole-1 - acetate, ethyl 5-chloro-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2,3- dihydro-1 H-indole-1 -acetate, ethyl 5-bromo-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, ethyl 5- iyodo-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazine iliden]-2,3-dihydro-1 H-indole-1 - acetate, ethyl 5-cyano-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazi neiliden]-2,3- dihydro-1 H-indole-1 -acetate, ethyl 5-karbamoil-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, Sodium 1 - (2-etoxy-2-oxoethyl)-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamo tioil]hydrazineiliden]-2,3- dihydro-1 H-indole-5-sulphonate, ethyl 6-bromo-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, ethyl 7- methyl-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazin eiliden]-2,3-dihydro-1 H-indole- 1 -acetate, ethyl 7-trifluoromethyl-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, ethyl 7- metoxy-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazin eiliden]-2,3-dihydro-1 H-indole- 1 -acetate, ethyl 7-fluoro-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2,3- dihydro-1 H-indole-1 -acetate, ethyl 7-chloro-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, ethyl 7- bromo-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazine iliden]-2,3-dihydro-1 H-indole- 1 -acetate, ethyl 7-fluoro-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2,3- dihydro-1 H-indole-1 -acetate, ethyl 5-fluoro-6-chloro-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, ethyl 5- chloro-7-methyl-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil ]hydrazineiliden]-2,3-dihydro- 1 H-indole-1 -acetate, ethyl 5,7-dichloro-2-oxo-3-[2-[(2- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -acetate, ethyl 5,7- dibromo-2-oxo-3-[2-[(2-sulphamoilphenyl)karbamotioil]hydrazi neiliden]-2,3-dihydro-1 H- indole-1 -acetate.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1 -Benzyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-A/-(2- sulphamoilphenyl)hydrazinecarbothioamide s

S0 ₂ NH ₂

and from its derivatives, for instance2-(1 -benzyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-[1 -benzyl-5-(propane-2- yl)-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -benzyl-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-fluoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-5-chloro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - benzyl-5-bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-iyodo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-5-nitro-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - benzyl-5-cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-karbamoil-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, Sodium 3-[1 -benzyl-2-oxo- 3-[2-(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dih ydro-1 - -indole-5-sulphonate, 2- (1 -benzyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-6-fluoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-6-chloro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - benzyl-6-bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-7-fluoro-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - benzyl-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-bromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(2-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -benzyl-5-fluoro-6- chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-chloro-7-methyl-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(2-sulphamoilphenyl)hydrazineca rbothioami^ 2-(1 -benzyl- 5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5,7-dibromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(2-sulphamoilphenyl)hydrazinecarbothioami de.

In an application of the present invention, the compounds shown by Formula III are selected from 2-[1-(4-trifluoromethylbenzyl)-2-oxo-1 ,2-dihydro-3W-indole-3-yliden]-A -(2- sulphamoilphenyl)hydrazinecarbothioamide and from its derivatives, for instance2-[1 -(4-trifluoromethylbenzyl)-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide,2-[1 -(4- trifluoromethylbenzyl)-5-methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trifluoromethylbenzyl)-5-(propane-2-yl)-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide,2-[1 -(4- trifluoromethylbenzyl)-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trifluoromethylbenzyl)-5-metoxy-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide,2-[1 -(4- trifluoromethylbenzyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trifluoromethylbenzyl)-5-fluoro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide,2-[1 -(4- trifluoromethylbenzyl)-5-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trifluoromethylbenzyl)-5-bromo-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide,2-[1 -(4- trifluoromethylbenzyl)-5-iyodo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trifluoromethylbenzyl)-5-nitro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide,2-[1 -(4- trifluoromethylbenzyl)-5-cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trifluoromethylbenzyl)-5-karbamoil-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, sodium 3- [1 -(4-trifluoromethylbenzyl)-2-oxo-3-[2-(sulphamoilphenyl)karb amotioil]hydrazineiliden]-2,3- dihydro-1 7-indole-5-sulphonate,2-[1 -(4-trif luoromethylbenzyl)-5-sulphamoil-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioam

trifluoromethylbenzyl)-6-fluoro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trif luoromethylbenzyl)-6-chloro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioamide,2-[

trifluoromethylbenzyl)-6-bromo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trif luoromethylbenzyl)-7-methyl-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide,2-[ trifluoromethylbenzyl)-7-trifluoromethyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trif luoromethylbenzyl)-7-metoxy-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide,2-[ trifluoromethylbenzyl)-7-fluoro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trif luoromethylbenzyl)-7-chloro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioamide,2-[1 -^ trifluoromethylbenzyl)-7-bromo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(4-trif luoromethylbenzyl)-5-fluoro-6-chloro-2- oxo-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide,2-[1 ^ trifluoromethylbenzyl)-5-chloro-7-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(4-trif luoromethylbenzyl)-5,7-dichloro-2- oxo-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 - (4-trif luoromethylbenzyl)-5,7-dibromo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-[1-(3-trifluoromethylbenzyl)-2-oxo-1 ,2-dihydro-3W-indole-3-yliden]-A -(2- sulphamoilphenyl)hydrazinecarbothioamide

and from its derivatives, for instance2-[1 -(3-trifluoromethylbenzyl)-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-[1 -(3- trifluoromethylbenzyl)-5-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(3-trifluoromethylbenzyl)-5-(propane-2-yl)-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 (3-trifluoromethylbenzyl)-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-5-metoxy-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 -(3- trifluoromethylbenzyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3/-/-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-5-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(3- trifluoromethylbenzyl)-5-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-5-bromo-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 -(3- trifluoromethylbenzyl)-5-iyodo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-5-nitro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioamide,2-[1 -(3- trifluoromethylbenzyl)-5-cyano-2-oxo-1 ,2-dihydro-3Hindole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-5-karbamoil-2- oxo-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide, sodium 3-[1 -(3-trifluoromethylbenzyl)-2-oxo-3-[2- (sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro- 1 H-indole-5-sulphonate,^ trifluoromethylbenzyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(3-trifluoromethylbenzyl)-6-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioamide,2-[1 -(3- trifluoromethylbenzyl)-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(3-trifluoromethylbenzyl)-6-bromo-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide,2-[1 -^ trifluoromethylbenzyl)-7-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-7-trifluoromethyl- 2-0X0-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 - (3-trifluoromethylbenzyl)-7-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-7-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(3- trifluoromethylbenzyl)-7-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-7-bromo-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 -(3- trifluoromethylbenzyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(3-trifluoromethylbenzyl)-5-chloro-7-methyl- 2-0X0-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 - (3-trifluoromethylbenzyl)-5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(3-trifluoromethylbenzyl)-57-dibromo-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioamide. In an application of the present invention, the compounds shown by Formula III are selected from 2-[1-(2-trifluoromethylbenzyl)-2-oxo-1 ,2-dihydro-3W-indole-3-yliden]-A -(2- sulphamoilphenyl)hydrazinecarbothioamide

and from its derivatives, for instance2-[1 -(2-trifluoromethylbenzyl)-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioam ide, 2-[1 -(2- trifluoromethylbenzyl)-5-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-5-(propane-2-yl)- 2-0X0-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 - (2-trifluoromethylbenzyl)-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trif luoromethylbenzyl)-5-metoxy-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide,2-[1 -(2- trifluoromethylbenzyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-5-fluoro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide,2-[1 -(2- trifluoromethylbenzyl)-5-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-5-bromo-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- trifluoromethylbenzyl)-5-iyodo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-5-nitro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- trifluoromethylbenzyl)-5-cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-5-karbamoil-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, sodium 3-[1 -(2-trif luoromethylbenzyl)-2-oxo-3-[2-

(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihyd ro-1 - -indole-5-sulphonate, 2-[1 -(2-thfluoromethylbenzyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(2-trif luoromethylbenzyl)-6-fluoro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- trifluoromethylbenzyl)-6-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trif luoromethylbenzyl)-6-bromo-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- trifluoromethylbenzyl)-7-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-7-trifluoromethyl- 2-0X0-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin e 2-[1 -

(2-trifluoromethylbenzyl)-7-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-7-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioamid 2-[1 -(2- trifluoromethylbenzyl)-7-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-7-bromo-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioam 2-[1 -(2- trifluoromethylbenzyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide,2-[1 -(2-trifluoromethylbenzyl)-5-ch

2-0X0-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin e 2-[1 -

(2-trifluoromethylbenzyl)-5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-A -(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-trifluoromethylbenzyl)-5,7-dibromo-2- oxo-1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioami

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1-Naphtylmethyl-2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(2-sulphamoilphenyl) mide

and from its derivatives, for instance2-[1 -(1 -naphtylmethyl)-2-oxo-1 ,2-dihydro-3H-indole-3- yliden]-N-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-methyl-2- oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazi necarbothioamide, 2-[1 - (1 -naphtylmethyl)-5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-t-butyl-2-oxo-1 ,2- dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinec arbothioamide, 2-[1 -(1 - naphtylmethyl)-5-metoxy-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-trif luorometoxy-2-oxo- 1 ,2-dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazi necarbothioamide, 2-[1 -(1 - naphtylmethyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-fluoro-2-oxo-1 ,2- dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinec arbothioamide, 2-[1 -(1 - naphtylmethyl)-5-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-bromo-2-oxo-1 ,2- dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinec arbothioami 2-[1 -(1 - naphtylmethyl)-5-iyodo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-nitro-2-oxo-1 ,2- dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinec arbothioami 2-[1 -(1 - naphtylmethyl)-5-cyano-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-karbamoil-2-oxo-1 ,2- dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinec arbothioami Sodium 3-[1 - (1 -naphtylmethyl)-2-oxo-3-[2-(sulphamoilphenyl)karbamotioil]hy drazineiliden]-2,3-di

1 H-indole-5-sulphonate, 2-[1 -(1 -naphtylmethyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3- yliden)-N-(2-sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-6-fluoro-2- oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(2-sulphamoilphenyl]hydrazi necarbothioamide, 2-[1 - (1 -naphtylmethyl)-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-6-bromo-2-oxo-1 ,2- dihydro-3H-indole-3-yliden)-N-(2-sulphamoilphenyl]hydrazinec arbothioamide, 2-[1 -(1 - naphtylmethyl)-7-methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-trifluoromethyl-2-oxo- 1 ,2-dihydro-3H-indole-3-yliden)-N-(2-sulphamoilphenyl]hydrazi necarbothioamide, 2-[1 -(1 - naphtylmethyl)-7-metoxy-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-fluoro-2-oxo-1 ,2- dihydro-3H-indole-3-yliden)-N-(2-sulphamoilphenyl]hydrazinec arbothioamide, 2-[1 -(1 - naphtylmethyl)-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-bromo-2-oxo-1 ,2- dihydro-3H-indole-3-yliden)-N-(2-sulphamoilphenyl]hydrazinec arbothioamide, 2-[1 -(1 - naphtylmethyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-chloro-7-methyl-2-oxo- 1 ,2-dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazi necarbothioamide, 2-[1 -(1 - naphtylmethyl)-5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5,7-dibromo-2-oxo-1 ,2- dihydro-3H-indole-3-yliden]-N-(2-sulphamoilphenyl)hydrazinec arbothioamide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(2-Naphtylmethyl-2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(2- sulphamoilphenyl)hydrazinecarbothioamide

and from its derivatives, for instance2-[1 -(2-naphtylmethyl)-2-oxo-1 ,2-dihydro-3Hindole-3- yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-methyl-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 - (2-naphtylmethyl)-5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-t-butyl-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-trifluorometoxy-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-fluoro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-bromo-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-iyodo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-nitro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-cyano-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-karbamoil-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(2-sulphamoilphenyl)hydrazinecarbothioa mide, sodium 3-[1 -(2- naphtylmethyl)-2-oxo-3-[2-(sulphamoilphenyl)karbamotioil]hyd razineiliden]-2,3-dihydro-1 - - indole-5-sulphonate, 2-[1 -(2-naphtylmethyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(2-sulphamoilphenyl]hydrazinecarbothioamide,2-[1 -(2-naphtylmethyl)-6-fluoro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 - (2-naphtylmethyl)-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-6-bromo-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-7-methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-trifluoromethyl-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-7-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(2-sulphamoilphenyl]hydrazineca rbothioami 2-[1 -(2- naphtylmethyl)-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(2-sulphamoilphenyl]hydrazineca rbothioami 2-[1 -(2- naphtylmethyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(2- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-chloro-7-methyl-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazin ecarbothioam 2-[1 -(2- naphtylmethyl)-5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-A -(2- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5,7-dibromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(2-sulphamoilphenyl)hydrazineca rbothioam

In an application of the present invention, the compounds shown by Formula III are selected from 2-(2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(3-sulphamoilphenyl) hydrazinecarbothioamide

and from its derivatives, for instance2-(2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(5-methyl-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-[5-(propane-2-yl)-2-oxo-1 ,2- dihydro-3H-indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazine carbothioamide, 2-(5-t-butyl-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(5- metoxy-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(5-trifluorometoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(5-fluoro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(5-chloro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3-sulphamoilphenylhydrazinecarbothioam ide, 2-(5- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(5-iyodo-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-(5-nitro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(5-cyano-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(5- karbamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, Sodium 3-[2-oxo-3-[3- (sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro- 1 H-i

sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(6-fluoro-2-oxo-1 ,2-dihydro-3 - -indole-3- yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-(6-chloro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(6-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazineca rbothioam 2-(7-methyl-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazin ecarbothioam 2-(7- trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(7-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3- yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-(7-fluoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(7-chloro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazineca ^ 2-(7-bromo-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazin ecarbothioam Methyl 3-[2-oxo-3-[3-(sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-7- yl]prop-2-enoat, 2-(5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(5-chloro-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(5,7-dichloro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazineca rbothioamide, 2-(5,7- dibromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1-Methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-A/-(3- sulphamoilphenyl)hydrazinecarbothioamide

and from its derivatives, for instance2-(1 -methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 ,5-dimethyl-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -methyl-5-(propane-2-yl)-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-f luoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -methyl-5-chloro-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazin ecarbothioam 2-(1 - methyl-5-bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-iyodo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -methyl-5-nitro-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazin ecarbothioam 2-(1 - methyl-5-cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-karbamoil-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, Sodium 3-[1 -methyl-2-oxo- 3-[3-(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dih ydro-1 Hindole-5-sulph 2- (1 -methyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-6-f luoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-6-chloro-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazin ecarbothioamide, 2-(1 - methyl-6-bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-A -(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-7-fluoro-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazin ecarbothioamide, 2-(1 - methyl-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-bromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-5-fluoro-6- chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-chloro-7-methyl-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl)hydrazineca rbothioamide, 2-(1 -methyl- 5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5,7-dibromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1-Ethyl-2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(3-sulphamoilphenyl) hydrazinecarbothioamide

and from its derivatives, for instance2-(1 -ethyl-2-oxo-1 ,2-dihydro-3/-/-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-[1 -ethyl-5-(propane-2- yl)-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide,

2- (1 -ethyl-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -ethyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-fluoro-2-oxo-1 ,2-dihydro-3 7-indole-

3- yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide,2-(1 -ethyl-5-chloro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-5- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-iyodo-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-nitro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-5- cyano-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-karbamoil-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, Sodium 3-[1 -ethyl-2-oxo-3- [3-(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihyd ro-1 7-indole-5-sulphonate, 2-(1 - ethyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-6-fluoro-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-6-chloro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-6- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -ethyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -ethyl-7-f luoro-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide:, 2-(1 -ethyl- 7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-bromo-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-chloro-7-methyl-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sul^ 2-(1 - ethyl-5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5,7-dibromo-2-oxo-1 ,2-dihydro-3H indole-3-yliden)-/V-(3-sulphamoilphenyl) hydrazinecarbothioamide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-

and from its derivatives, for instance2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid,5- methyl-2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazin eilidene]-2,3-dihydro-1 - -indole-

1 - aceticacid,5-(propane-2-yl)-2-oxo-3-[2-[(3-sulphamoilphenyl) karbamotioil]hydrazineilidene]- 2,3-dihydro-1 H-indole-1 -aceticacid,5-t-butyl-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid, 5- metoxy-2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazin eilidene]-2,3-dihydro-1 H- indole-1 -aceticacid, 5-trifluorometoxy-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid, 5-fluoro-

2- oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazineilidene] -2,3-dihydro-1 H-indole-1 - aceticacid, 5-chloro-2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydraz ineilidene]-2, 3- dihydro-1 H-indole-1 -aceticacid, 5-bromo-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid, 5-iyodo- 2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazineiliden e]-2,3-dihydro-1 H-indole-1 - aceticacid, 5-cyano-2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazi neilidene]-2, 3- dihydro-1 H-indole-1 -aceticacid, 5-karbamoil-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid, sodium

1 - (carboxymethyl)-2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil ]hydrazineilidene]-2,3- dihydro-1 H-indole-5-sulphonate,6-fluoro-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid, 6-chloro-

2- oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazineilidene] -2,3-dihydro-1 H-indole-1 - aceticacid, 6-bromo-2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazi neilidene]-2, 3- dihydro-1 H-indole-1 -aceticacid, 7-methyl-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid, 7- trifluoromethyl-2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil ]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid,7-metoxy-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- ^

2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazineili dene]-2,3-dihydro-1 H^

aceticacid,7-chloro-2-oxo-3-[2-[(3-sulphamoilphenyl)karba m

dihydro-1 H-indole-1 -aceticacid,7-bromo-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid,7-fluoro- 2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydrazineiliden e]-2,3-dihydro-1 H-indole-1 - aceticacid,5-fluoro-6-chloro-2-oxo-3-[2-[(3-sulphamoilphenyl )karbamotioil]hydrazineilidene]- 2,3-dihydro-1 H-indole-1 -aceticacid,5-chloro-7-methyl-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid,5,7- dichloro-2-oxo-3-[2-[(3-sulphamoilphenyl)karbamotioil]hydraz ineilidene]-2,3-dihydro-1 H- indole-1 -aceticacid,5,7-dibromo-2-oxo-3-[2-[(3- sulphamoilphenyl)karbamotioil]hydrazineilidene]-2,3-dihydro- 1 H-indole-1 -aceticacid.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1 -Benzyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide and from its derivatives, for instance2-(1 -benzyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-methyl-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-[1 -benzyl-5-(propane-2- yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-N-(3-sulphamoilphenyl)hydrazi necarbothioamide, 2-(1 -benzyl-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-metoxy-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -benzyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-fluoro-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -benzyl-5-chloro-2- oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazi necarbothioamide, 2-(1 - benzyl-5-bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-iyodo-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -benzyl-5-nitro-2-oxo- 1 ,2-dihydro-3H-indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazi necarbothioamide, 2-(1 - benzyl-5-cyano-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-karbamoil-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, Sodium 3-[1 -benzyl-2-oxo- 3-[3-(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dih ydro-1 H-indole-5-sulp 2- (1 -benzyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-6-fluoro-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -benzyl-6-chloro-2- oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazi necarbothioamide, 2-(1 - benzyl-6-bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-methyl-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -benzyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-metoxy-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -benzyl-7-fluoro-2-oxo- 1 ,2-dihydro-3H-indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazi necarbothioamide, 2-(1 - benzyl-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-bromo-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -benzyl-5-fluoro-6- chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-chloro-7-methyl-2-oxo-1 ,2- dihydro-3H-indole-3-yliden)-N-(3-sulphamoilphenyl)hydrazinec arbothioamide, 2-(1 -benzyl- 5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-N-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5,7-dibromo-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(3-sulphamoilphenyl) hydrazinecarbothioamide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-[1-(1-naphtylmethyl)-2-oxo-1 ,2-dihydro-3W-indole-3-yliden]-A -(3- sulphamoilphenyl) hydrazinecarbothioamide

and from its derivatives, for instance2-[1 -(1 -naphtylmethyl)-2-oxo-1 ,2-dihydro-3 - -indole-3- yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-methyl-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 - (1 -naphtylmethyl)-5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-t-butyl-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-5-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-trif luorometoxy-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 -(1 - naphtylmethyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-5-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/\/-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-5-iyodo-2-oxo-1 ,2-dihydro-3Hindole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-nitro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-5-cyano-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-karbamoil-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazineca rbothioamide, Sodium 3-[1 -

(1 -naphtylmethyl)-2-oxo-3-[3-(sulphamoilphenyl)karbamotioil]hy drazineiliden]-2,3-di

1 H-indole-5-sulphonate, 2-[1 -(1 -naphtylmethyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(3-sulphamoilphenyl]hydrazinecarbothioamide,2-[1 -(1 -naphtylmethyl)-6-fluoro-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazin ecarbothioamide, 2-[1 - (1 -naphtylmethyl)-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-6-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-7-methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-trifluoromethyl-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazin ecarbothioamide, 2-[1 -(1 - naphtylmethyl)-7-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-chloro-7-methyl-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 -(1 - naphtylmethyl)-4,5-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5,7-dichloro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazineca rbothioam 2-[1 -(1 - naphtylmethyl)-5,7-dibromo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-[1-(2-naphtylmethyl)-2-oxo-1 ,2-dihydro-3W-indole-3-yliden]-A -(3- sulphamoilphenyl) hydrazinecarbothioamide

and from its derivatives, for instance2-[1 -(2-naphtylmethyl)-2-oxo-1 ,2-dihydro-3Hindole-3- yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-methyl-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 - (2-naphtylmethyl)-5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-t-butyl-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-trifluorometoxy-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-fluoro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-bromo-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-iyodo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-nitro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-karbamoil-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(3-sulphamoilphenyl)hydrazinecarbothioa mide, sodium 3-[1 -(2- naphtylmethyl)-2-oxo-3-[3-(sulphamoilphenyl)karbamotioil]hyd razineiliden]-2,3-dihydro-1 - - indole-5-sulphonate, 2-[1 -(2-naphtylmethyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-N-(3-sulphamoilphenyl]hydrazinecarbothioamide,2-[1 -(2-naph

oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilph 2-[1 -

(2-naphtylmethyl)-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-6-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazineca rbothioamide 2-[1 -(2- naphtylmethyl)-7-methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-trifluoromethyl-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazin ecarbothioami 2-[1 -(2- naphtylmethyl)-7-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazineca rbothioamide 2-[1 -(2- naphtylmethyl)-7-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(3-sulphamoilphenyl]hydrazineca rbothioamide 2-[1 -(2- naphtylmethyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-chloro-7-methyl-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazin ecarbothioam 2-[1 -(2- naphtylmethyl)-5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(3- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5,7-dibromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(3-sulphamoilphenyl)hydrazineca rbothioamide

In an application of the present invention, the compounds shown by Formula III are selected from 2-(2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(4-sulphamoilphenyl) hydrazinecarbothioamide

and from its derivatives, for instance2-[5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3- yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-(5-t-butyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(5-metoxy-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(5-iyodo-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(5- cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(5-karbamoil-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, Sodium 3-[2-oxo-3-[4- (sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihyd 2-(5- sulphamoil-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(6-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioami de, 2-(6-chloro-7-methyl-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioam 2-(6- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(7-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3- yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-(7-trifluoromethyl-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazineca rbothioam 2-(7-metoxy-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioam 2-(7- fluoro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(7-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3- yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-(7-bromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioami de, 2-(5-fluoro-6-chloro-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioami 2-(5- chloro-7-methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(5,7-dichloro-2-oxo-1 ,2-dihydro-3 - -indole-3- yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioamide. In an application of the present invention, the compounds shown by Formula III are selected from 2-(1-Methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-A/-(4- sulphamoilphenyl)hydrazinecarbothioamide

and from its derivatives, for instance2-(1 -methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 ,5-dimethyl-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -methyl-5-(propane-2-yl)-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-f luoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-5-chloro-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin eca 2-(1 - methyl-5-bromo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-iyodo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -methyl-5-nitro-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioam 2-(1 - methyl-5-cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-karbamoil-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioami de, Sodium 3-[1 -methyl-2-oxo- 3-[4-(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dih ydro-1 Hindole-5-sulp 2- (1 -methyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-6-f luoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-6-chloro-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioamide, 2-(1 - methyl-6-bromo-2-oxo-1 ,2-dihydro-3Hindole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-7-fluoro-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioamide, 2-(1 - methyl-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-7-bromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -methyl-5-fluoro-6- chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5-chloro-7-methyl-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazineca rbothioamide, 2-(1 -methyl- 5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-5,7-dibromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1 -Ethyl-2-oxo-1 ,2-d i hyd ro-3 W-i ndole-3-yl iden)-A -(4- razinecarbothioamide

and from its derivatives, for instance2-(1 -ethyl-2-oxo-1 ,2-dihydro-3/-/-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl) hydrazinecarbothioamide, 2-(1 -ethyl-5-methyl-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl) hydrazinecarbothioamide, 2-[1 -ethyl- 5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-t-butyl-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-metoxy-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-fluoro-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-chloro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-5- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-iyodo-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-nitro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-5- cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-karbamoil-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, Sodium 3-[1 -ethyl-2-oxo-3- [4-(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihyd ro-1 7-indole-5-sulphonate, 2-(1 - ethyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-6-fluoro-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -methyl-6-chloro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 -ethyl-6- bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -ethyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -ethyl-7-f luoro-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - methyl-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-7-bromo-2-oxo-1 ,2-dihydro-3 7-indole- 3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5-fluoro-6-chloro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-(1 - ethyl-5-chloro-7-methyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -ethyl-5,7-dichloro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioami de, 2-(1 -ethyl-5,7-dibromo-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioam

In an application of the present invention, the compounds shown by Formula III are selected from 2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H- indole-1-aceticacid

and from its derivatives, for instance2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 - -indole-1 -aceticacid,5-methyl- 2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid,5-(propane-2-yl)-2-oxo-3-[2-[(4-sulphamoilphenyl) karbamotioil]hydrazineiliden]- 2,3-dihydro-1 H-indole-1 -aceticacid, 5-t-butyl-2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 5-metoxy- 2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid, 5-trifluorometoxy-2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotio il]hydrazineiliden]- 2,3-dihydro-1 H-indole-1 -aceticacid, 5-f luoro-2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 5-chloro- 2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid, 5-bromo-2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazi neiliden]-2, 3- dihydro-1 H-indole-1 -aceticacid, 5-iyodo-2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 5-cyano- 2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid, 5-karbamoil-2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hyd razineiliden]-2, 3- dihydro-1 H-indole-1 -aceticacid, sodium 1 -(carboxymethyl)-2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-5-sulphonate, 6-fluoro- 2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid, 6-chloro-2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2, 3- dihydro-1 H-indole-1 -aceticacid, 6-bromo-2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 7-methyl- 2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazineiliden ]-2,3-dihydro-1 H-indole-1 - aceticacid, 7-trifluoromethyl-2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotio il]hydrazineiliden]- 2,3-dihydro-1 H-indole-1 -aceticacid, 7-metoxy-2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 7-fluoro-2- oxo-3-[2-[(4-sulphamoilphenyl)karbam

aceticacid, 7-chloro-2-oxo-3-[2-[(4-sulphamoilphenyl)karbam

dihydro-1 H-indole-1 -aceticacid, 7-bromo-2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-^

oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydrazineilide n]-2,3-dihydro-1 H-indole-1 - aceticacid,5-fluoro-6-chloro-2-oxo-3-[2-[(4-sulphamoilphenyl )karbamotioil]hydrazineiliden 2,3-dihydro-1 H-indole-1 -aceticacid, 5-chloro-7-methyl-2-oxo-3-[2-[(4- sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dihydro-1 H-indole-1 -aceticacid, 5,7- dichloro-2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydraz ineiliden]-2,3-dihydro-1 H-indole- 1 -aceticacid, 5, 7-dibromo-2-oxo-3-[2-[(4-sulphamoilphenyl)karbamotioil]hydra zineiliden]-2,3- dihydro-1 H-indole-1 -aceticacid.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1 -Benzyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-A/-(4- sulphamoilphenyl)hydrazinecarbothioamide and from its derivatives, for instance2-(1 -benzyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-methyl-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-[1 -benzyl-5-(propane-2- yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(4-sulphamoilphenyl)hydraz inecarbothioamide, 2-(1 -benzyl-5-t-butyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-metoxy-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-5- trifluorometoxy-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-fluoro-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-5-chloro-2- oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4-sulphamoilphenyl)hydraz inecarbothioamide, 2-(1 - benzyl-5-bromo-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-iyodo-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-5-nitro-2-oxo- 1 ,2-dihydro-3H-indole-3-yliden)-/V-(4-sulphamoilphenyl)hydraz inecarbothioamide, 2-(1 - benzyl-5-cyano-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-karbamoil-2-oxo-1 ,2-dihydro-3H- indole-3-yliden)-N-(4-sulphamoilphenyl)hydrazinecarbothioami de, Sodium 3-[1 -benzyl-2-oxo- 3-[4-(sulphamoilphenyl)karbamotioil]hydrazineiliden]-2,3-dih ydro-1 Hindole-5-sul^ 2- (1 -benzyl-5-sulphamoil-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-6-fluoro-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-6-chloro-2- oxo-1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioamide, 2-(1 - benzyl-6-bromo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-methyl-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-7- trifluoromethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-metoxy-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-7-fluoro-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazin ecarbothioamide, 2-(1 - benzyl-7-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-7-bromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide, 2-(1 -benzyl-5-fluoro-6- chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5-chloro-7-methyl-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl)hydrazineca rbothioamide, 2-(1 -benzyl- 5,7-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-(1 -benzyl-5,7-dibromo-2-oxo-1 ,2-dihydro-3 7- indole-3-yliden)-/V-(4-sulphamoilphenyl)hydrazinecarbothioam ide.

In an application of the present invention, the compounds shown by Formula III are selected from 2-(1 -Naphtylmethyl-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-A/-(4- sulphamoilphenyl)hydrazinecarbothioamide

and from its derivatives, for instance2-[1 -(1 -naphtylmethyl)-2-oxo-1 ,2-dihydro-3 - -indole-3- yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-methyl-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 - (1 -naphtylmethyl)-5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-t-butyl-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazineca rbothioami 2-[1 -(1 - naphtylmethyl)-5-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-trif luorometoxy-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazin ecarbothioamide, 2-[1 -(1 - naphtylmethyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-5-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-5-iyodo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-nitro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazineca rbothioamide, 2-[1 -(1 - naphtylmethyl)-5-cyano-2-oxo-1 ,2-dihydro-3Hindole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-karbamoil-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazineca rbothioamide, sodium 3-[1 -(1 - naphtylmethyl)-2-oxo-3-[4-(sulphamoilphenyl)karbamotioil]hyd razineiliden]-2,3-dihydro-1 - - indole-5-sulphonate, 2-[1 -(1 -naphtylmethyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-N-(4-sulphamoilphenyl]hydrazinecarbothioamide,2-[1 -(1 -naphtylmethyl)-6-fluoro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 - (1 -naphtylmethyl)-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-6-bromo-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 -(1 - naphtylmethyl)-7-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-trifluoromethyl-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 -(1 - naphtylmethyl)-7-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-fluoro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 -(1 - naphtylmethyl)-7-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-7-bromo-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 -(1 - naphtylmethyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3/-/-indole-3-yliden]-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5-chloro-7-methyl-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(1 - naphtylmethyl)-5,7-dichloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(1 -naphtylmethyl)-5,7-dibromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazineca rbothioam

In an application of the present invention, the compounds shown by Formula III are selected from 2-(2-Naphtylmethyl-2-oxo-1 ,2-dihydro-3W-indole-3-yliden)-A -(4- sulphamoilphenyl)hydrazinecarbothioamide

and from its derivatives, for instance 2-[1 -(2-naphtylmethyl)-2-oxo-1 ,2-dihydro-3 - -indole- 3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-methyl- 2-OXO-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 - (2-naphtylmethyl)-5-(propane-2-yl)-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-t-butyl-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-trifluorometoxy-2-oxo- 1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-trifluorometoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-fluoro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-bromo-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-iyodo-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-nitro-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, 2-[1 -(2- naphtylmethyl)-5-cyano-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-karbamoil-2-oxo-1 ,2- dihydro-3 - -indole-3-yliden]-/V-(4-sulphamoilphenyl)hydrazinecarbothioa mide, Sodium 3-[1 - (2-naphtylmethyl)-2-oxo-3-[4-(sulphamoilphenyl)karbamotioil] hydrazineiliden]-2,3-dihydro- 1 H-indole-5-sulphonate, 2-[1 -(2-naphtylmethyl)-5-sulphamoil-2-oxo-1 ,2-dihydro-3 7-indole-3- yliden)-/V-(4-sulphamoilphenyl]hydrazinecarbothioamide,2-[1 -(2-naphtylmethyl)-6-fluoro-2- oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4-sulphamoilphenyl]hydrazinecarbothioa mide, 2-[1 - (2-naphtylmethyl)-6-chloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden)-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-6-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl]hydrazineca rbothioam 2-[1 -(2- naphtylmethyl)-7-methyl-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-trifluoromethyl-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden)-N-(4-sulpham 2-[1 -(2- naphtylmethyl)-7-metoxy-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-fluoro-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl]hydrazineca rbothioam^ 2-[1 -(2- naphtylmethyl)-7-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden)-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-7-bromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden)-N-(4-sulphamoilphenyl]hydrazineca rbothioam^ 2-[1 -(2- naphtylmethyl)-5-fluoro-6-chloro-2-oxo-1 ,2-dihydro-3 - -indole-3-yliden]-/V-(4- sulphamoilphenyl]hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5-chloro-7-methyl-2-oxo- 1 ,2-dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazin ecarbothioam 2-[1 -(2- naphtylmethyl)-57-dichloro-2-oxo-1 ,2-dihydro-3H-indole-3-yliden]-/V-(4- sulphamoilphenyl)hydrazinecarbothioamide, 2-[1 -(2-naphtylmethyl)-5,7-dibromo-2-oxo-1 ,2- dihydro-3Hindole-3-yliden]-N-(4-sulphamoilphenyl)hydrazineca rbothioam

Thus, from one perspective, the present invention relates to molecules shown by Formula II and Formula III whose general structures and specific examples are given above.

From another perspective, the present invention relates to a method to be used in preparation of the molecules shown by Formula II. In an application of the present invention, the substances shown by Formula II described in the present invention can be prepared by means of different methods by taking into consideration the beginning substances shown by Formula I.

In order to describe the molecule shown by Formula I, the terms of "Formula I", "1 H-indole- 2,3-dione derivatives", "isatin derivatives" or " can be interchangeably used.

In the subject matter method, the beginning substance shown by Formula I and R ₄ Y are used;

Here;

R _{1 =} H, CH ₃ , CH(CH ₃ ) ₂ , C(CH ₃ ) ₃ , OCH ₃ , OCF ₃ , F, CI, Br, I, N0 ₂ , CN, CONH ₂ , S0 ₃ Na, S0 ₂ NH ₂ ,

Y= CI, Br, I

R ₂ = H, F, CI, Br

R ₃ = H, CH ₃ , CF ₃ , OCH ₃ , F, CI, Br

R _{1 =} F, R ₂ = CI; R _{1 =} CI, R ₃ = CH ₃ ; R _{1 =} R ₃ = CI; R _{1 =} R ₃ = Br

R ₄ = H, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , CH(CH ₃ ) ₂ , CH ₂ CH=CH ₂ , CH ₂ COOH, (CH ₂ ) ₂ COOH, CH(CH ₃ )COOH, (CH ₂ ) ₃ COOH, CH ₂ COOC ₂ H ₅ , CH ₂ COOCH(CH ₃ ) ₂ , CH ₂ COOC(CH ₃ ) ₃ , (CH ₂ ) ₂ COOC ₂ H _5! CH(CH ₃ )COOC ₂ H _5! (CH ₂ ) ₃ COOC ₂ H ₅

The specific procedures related to preparation of Formula II molecule by means of the subject matter method are given in examples section, and all of said methods can be applied to the subject matter molecules.

From another perspective, the present invention relates to a method to be used in preparation of the molecules shown by Formula III.

In a method in accordance with the present invention, the Formula III compounds are obtained by means of (i) obtaining substance B from compound A shown below, (ii) afterwards, obtaining compound C from compound B and (iii) reacting this compound C with the compound shown by Formula I or II. Within the scope of the present invention, compound A is mentioned as "A", compound B is mentioned as "B" and compound C is mentioned as "C".

In this method, first of all, compound A is transformed into compound B (i):

Here, it is shown as R ₅ = R ₆ = R ₇ = H, S0 ₂ NH ₂ . und C (ii):

Here, it is shown as R ₅ = R ₆ = R ₇ = H, S0 ₂ NH ₂ .

In the final step, this compound C is reacted with the compound shown by Formula I or II,

H, CH ₃ , CH(CH ₃ ) ₂ , C(CH ₃ ) ₃ , OCH ₃ , OCF ₃ , F, CI, Br, I, N0 ₂ , CN, CONH ₂ , S0 ₃ Na, S0 ₂ NH ₂ , R ₂ = H, F, CI, Br

R ₃ = H, CH ₃ , CF ₃ , OCH ₃ , F, CI, Br

R _{1 =} F, R ₂ = CI; R _{1 =} CI, R ₃ = CH ₃ ; R _{1 =} R ₃ = CI; R _{1 =} R ₃ = Br R ₄ = H, CH ₃ , C ₂ H ₅ , n-C ₃ H ₇ , CH(CH ₃ ) ₂ , CH ₂ CH=CH ₂ , CH ₂ COOH, (CH ₂ ) ₂ COOH, CH(CH ₃ )COOH, (CH ₂ ) ₃ COOH, CH ₂ COOC ₂ H ₅ , CH ₂ COOCH(CH ₃ ) ₂ , CH ₂ COOC(CH ₃ ) ₃ , (CH ₂ ) ₂ COOC ₂ H ₅ , CH(CH ₃ )COOC ₂ H ₅ , (CH ₂ ) ₃ COOC ₂ H ₅

R5= R6= R7= H, S02NH2

Y=

By means of the subject matter molecules shown by Formula II and Formula III, it is aimed to blunt the specifically related enzyme or receptor mechanisms against pluralities of diseases including the diseases in the cancer and immunity system. Within this scope, the molecules shown by Formula II and Formula III can be used as medicine in treatment of pluralities of diseases including cancer and the diseases of the immunity system. Now, the present invention will be described with reference to the below mentioned examples which are only for exemplary purposes and which shall not be interpreted to delimit the scope of the present invention in any manner. EXAMPLES:

Example 1 : 1st method which can be used in preparation of the Formula II substances

1 H-indole-2,3-dione (isatin) derivatives are heated and mixed for 1 hour at 40-60°C inside approximately 10 mL dimethyl formamide (DMF) where I (10 mmole) and potassium carbonate (K ₂ C0 ₃ ) (14.5 mmole) are solvents. R ₄ halogenure (1 1 .0 mmole) and potassium iodure (Kl) (2.0 mmole) as catalyst are added to the formed dark colored suspension. The mixture is continued to be heated and mixed at 40-60°C by being controlled by means of thin layer chromatography such that no I residue remains. The mixture is neutralized with hydrochloric acid (HCI), and it is extracted by means of 20 mL ethyl acetate four times and it is dried with the help of anhydrous sodium sulphate (Na ₂ S0 ₄ ). The solvent is removed from the medium under vacuum. The remaining solid part is purified with the help of column chromatography.

Example 2: 2nd method which can be used in preparation of the Formula II substances

I (0.01 mole) and K ₂ C0 ₃ (0.015 mmole) are mixed inside approximately 30 mL DMF as solvent such that I is completely dissolved. R ₄ halogenure (0.011 moles) is added in the form of small portions to the dark brilliant red colored suspension formed at the end of stirring 30 minutes, and it is stirred 12-14 hours more. The mixture formed at the end of the reaction is diluted with water. It is extracted with dichloromethane (CH ₂ CI ₂ ) and it is washed with water, and it is dried with the help of anhydrous Na ₂ S0 ₄ . The solvent is vaporized in roto vapor under pressure. The remaining solid part is purified and cleaned with the help of column chromatography including silica gel.

Example 3: 3rd method which can be used in preparation of the Formula II substances

I (0.66 mmole) is dissolved in approximately 4 mL DMF with K ₂ C0 ₃ or sodium hydride (NaH) (0.92 mmole). The mixture is mixed under nitrogen gas at 4°C for 3 hours. The formed I sodium salt is reacted with suitable R ₄ halogenure under the Kl catalyst, and it is heated for 18 hours more at 50°C. 80 mL water is added to the formed solution and 1 M HCI (2 mL) is added until pH is 1 . The formed suspension is filtered and the obtained precipitation is washed with water. The solid part is purified and cleaned with the help of flash chromatography.

Example 4: 4th method which can be used in preparation of the Formula II substances I (1 g) is dissolved by mixing in icy medium inside anhydrous DMF. After solid K ₂ C0 ₃ (7.2 mmole) is added, the temperature is brought to room temperature, and it is continued to be mixed for 1 hour. At the end of the duration, R ₄ halogenure (1 g) is added, and the reaction is heated and mixed for 5-24 hours at 80°C under the Kl (6 mmole) catalyst. The end of the reaction is controlled with TLC, and the mixture is poured into 50 ml_ HCI, and it is extracted with 50 ml ethyl acetate. The ethyl acetate layer is washed with salty water, and it is dried with the help of MgS0 ₄ , and it is removed from the medium under solvent vacuum.

Example 5: 5th method which can be used in preparation of the Formula II substances I (1 mmole) is dissolved in approximately 20 ml_ DMF. Anhydrous K ₂ C0 ₃ (3 mmole) is added to the reaction medium. The mixture is mixed at room temperature such that there remains no I residue. The solvent is removed from the medium under vacuum. The remaining solid part is purified and cleaned with the help of column chromatography. Example 6: 6th method which can be used in preparation of the Formula II substances

Γ (34 mmole) is added to solution in approximately 100 ml_ tetra hydrofuran (THF) with tersiyer potassium butoxide (tert-BuOK) (43.8 mmole) at 0°C. After the mixture is stirred for 30 minutes, R ₄ halogenure (40.8 mmole) is added drop by drop to the reaction medium at 0°C within duration of 20 minutes. The reaction temperature is brought to room temperature and it is stirred for 16 hours more. Afterwards, it is concentrated under low pressure. The remaining residue is dissolved in ethyl acetate. It is washed with water and it is dried with the help of MgS0 ₄ .The solid part is purified and cleaned with the help of flash chromatography.

Example 7: 7th method which can be used in preparation of the Formula II substances I (1 equiv.), Γ in 0.1 mmole corresponding to 1 ml_ is dissolved in anhydrous DMF. It is cooled and stirred in ice. Solid K ₂ C0 ₃ or cesium carbonate (Cs ₂ C0 ₃ ) (1 .2 equiv.) is added to the medium. The dark colored suspension formed is stirred for 1 hour at room temperature. R ₄ halogenure (1 .1 equiv.) and Kl (0.2 equiv.) are added thereon, and the reaction is heated and mixed for 5-24 hours at 80°C until there remains no I residue in the medium. The reaction mixture is poured into HCI (0.5 M, 50 ml_) and it is extracted with ethyl acetate. The ethyl acetate layer is washed with salty water. It is dried with the help of MgS0 ₄ . The solvent is removed from the medium and it is purified and cleaned with the help of solid flash chromatography. Example 8: 8th method which can be used in preparation of the Formula II substances

5 ml_ DMF is added to I (3 mmole) and calcium hydride (CaH ₂ ) (10 mmole) mixture. The obtained solution or suspension is stirred at 40-50°C and it is heated for 15-30 minutes. At the end of the duration, R ₄ halogenure is added to the reaction medium. Stirring continues at room temperature or at low temperature such that no I residue remains. The reaction mixture is poured into 10% NaCI (50 ml) aqueous solution acidified with 0.2 M HCI, and afterwards, it is extracted three times with 25 ml_ ethyl acetate. The part with ethyl acetate is separated, and it is washed with 25 ml_ salty water, and it is dried and filtered with the help of anhydrous Na ₂ S0 ₄ . The solvent is removed from the medium and solid part is purified and cleaned with the help of column chromatography.

Example 9: 9th method which can be used in preparation of the Formula II substances I (0.10 mmole) and CaH ₂ (0.10 mole) are stirred in 50 ml_ DMF. The reaction mixture is heated in oil bath for 1 hour at 100°C. At the end of the duration, the mixture is cooled down to approximately 40°C. Afterwards, R ₄ halogenure (1 10-150 mmole) is slowly added to medium. After the adding process is completed, the mixture is heated for 2-4 hours by being controlled chromatographically with ITK until there remains no isatin residue in the oil bath at 100°C. When it is cooled, the part precipitating in the medium is separated, and it is poured in watery HCI (200 ml_, 0.5 M). The watery solution is filtered and the remaining residue is washed with water. It is recommended to extract the watery part with ethyl acetate for increasing efficiency. The formed solid product is crystallized and cleaned from the hexane/ CHCI ₂ mixture.

Example 10: 10th method which can be used in preparation of the Formula II substances

NaH (13.19 mmol; in 60% dispersion mineral oil) at 0°C is added to the solution in I (10.99 mmole) 30 ml_ anhydrous DMF. The heterogeneous mixture is stirred for 1 hour at room temperature. R ₄ halogenure is added to the mixture at the end of the duration, and the mixture is continued to the stirred at room temperature for a night. At the end of the duration, cold icy water is added to the medium, and the precipitating solid part is filtered, and it is removed from the medium. It is washed with water and petrol ether and it is dried under vacuum.

Example 11 : 11th method which can be used in preparation of the Formula II substances

I (1 mmole), a suitable base (1 .3 mmole) (Na ₂ C0 ₃ , K ₂ C0 ₃ , Cs ₂ C0 ₃ , CaH ₂ , TEA, LiOH, NMM, NaEt) and R ₄ halogenure (1 .1 mmole) mixture is subjected to microwave rays under 160-400 watt energy for duration between 2-7 minutes inside polar aprotic solvent (DMF, DMA, HMPT, MeCN, DMSO, NMP). The reaction is cooled until room temperature. The compound, formed when it is substantially stirred with icy water, is filtered and removed from the medium.

Example 12: 12th method which can be used in preparation of the Formula II substances

The solution of sodium (0.8 g) in 16 ml_ absolute ethanol is added to I provided in suspension form in 24 ml_ absolute alcohol. The sodium salt of the formed purple-black colored I is removed from the medium. It is substantially washed with alcohol and benzene and dried. The sodium salt (1 mmole) of the obtained I and R ₄ halogenure (1 .1 mmole) are heated by being subject to microwave rays under 200-500 watt energy in durations changing between 3-5 minutes. The reaction is cooled down to room temperature. The compound formed when substantially mixed with icy water is filtered and removed from the medium.

Example 13: 13th method which can be used in preparation of the Formula II substances

Neutral aluminum (400 mg) is added to the solution of sodium salt (Na ) (1 mmole) of I in very small amount of water. The excessive portion of the solvent is vaporized in rato vapor, and the solid portion is dried at 1 10°C for one hour and the R ₄ halogenure (1 .1 mmole) is absorbed to the aluminum in I. The reaction is subjected to microwave rays under 400-800 watt energy in durations changing between 4-10 minutes. The mixture is extracted with CH ₂ CI ₂ after it is cooled down to room temperature. The solid part is purified after the solvent is vaporized.

Example 14: 14th method which can be used in preparation of the Formula II substances

I (2.1 1 mmole) is put into 1 ,8-diazabicyclo[5.4.0]undec-7-en (DBU) (1.1 eq) and R4 halogenure (1 .1 eq) 3 ml_ ethanol selected as base. With the help of a magnetic stirrer, the reaction is subjected to microwave radiation under power of 300 watt in durations changing between 10-25 minutes at 120-140°C and the reaction is heated. Afterwards the reaction is cooled down to room temperature. It is waited in a deep freezer for a night and it is filtered with the help of vacuum. The filtered portion is vaporized under low pressure. The greasy part is purified with the help of solid column chromatography.

Example 15: General Synthesis Method for 2/3/4-lsothiocyanato benzensulphonamide Derivatives (B)

10 g 2/3/4-aminobenzensulphonamide A (60 mmole)is dissolved in 100 ml water including 25 ml concentrated HCI. 6.79 g (60 mmole) thiophosgene is added to the mixture and afterwards, the mixture is stirred until the red color of the thiophosgene is removed. The formed white crystallized sulphamoil phenyl isothiocyanate is filtered and it is washed with water. Example 16: General Synthesis Method for [N-(2/3/4-Sulphamoil)phenyl]thiosemi carbazide Derivatives (C)

The solution of 10.7 g 2/3/4-isothiocyanatobenzene sulphonamide B (50 mmole) in 20 ml ethanol is added drop by drop to the solution of 2.4 ml (50 mmole) hydrazine hydrate which was cooled in icy water by stirring continuously. The precipitated product is filtered immediately, and it is crystallized from ethanol.

Example 17: 1st method which can be used in preparation of the Formula III substances

The solution of non-substituted/1 -substituted 1 H-indole-2,3-dione I or II (2 mmole) in 10 ml ethanol is heated and dissolved in water bath. 0.49 g [N-(2/3/4-sulphamoil)phenyl]thiosemi carbazide C (2 mmole) is added thereon. The mixture is heated under cooler which returns 2-6 hours and it is waited for a night. The formed product is filtered, and it is washed in ethanol or it is purified by means of crystallization. Example 18: 2nd method which can be used in preparation of the Formula III substances

The solution of I or II and C, having equal molar amount, in ethanol or anhydrous ethanol is heated under the cooler which returns to 2-8 hours in the presence of acid (H ₂ S0 ₄ , p-toluene sulphonic acid) added as catalyst. The formed product is filtered from the medium. It is cleaned by being washed with a suitable solvent and by being crystallized.

Example 19: 3rd method which can be used in preparation of the Formula III substances

As catalyst, 1 -2 drops of concentrated hydrochloric acid or glacial acetic acid (HCI, g.CH ₃ COOH) is added to the solution of I or II and C in ethanol, having equal molar amount, and the mixture is continuously stirred and it is heated for between 30 minutes to 1 -5 hours. It is cooled down to room temperature. It is waited for a night. The thiosemicarbazone which precipitates in the reaction medium is filtered and it is cleaned by being washed by cold alcohol. It is crystallized and cleaned from the suitable solvent.

Example 20: 4th method which can be used in preparation of the Formula III substances C is added to the solution of I or II having equal molar amount into the solution of approximately 30 ml_ ethanol. The mixture is heated for approximately 30 minutes - 2 hours. At the end of the duration, it is cooled down to room temperature and it is waited for a night. The precipitated solid substance is filtered and removed from the medium and it is washed by alcohol and dried.

Example 21 : 5th method which can be used in preparation of the Formula III substances

1 -2 drops of concentrated HCI acid is added as catalyst to the solution of I or II and C, having equal molar amount, in 20-30 ml_ ethanol. The reaction is stirred for 1 hour with the help of a magnetic stirrer at room temperature. The precipitating substance in the reaction medium is filtered and removed from the medium, and it is washed three times with 10 ml_ ethanol and it is cleaned. Example 22: 6th method which can be used in preparation of the Formula III substances

The solution of I or II (10 mmole), C (12 mmole) and triethylamin (0.4 mmole) mixture in 10 ml_ ethanol is heated by being mixed for 6 hours at 80 ⁵ C. When the reaction is cooled down to room temperature, the precipitated III is filtered from the medium and it is washed and cleaned by approximately 25 ml_ ethanol.

Example 23: 7th method which can be used in preparation of the Formula III substances

I or II (0.01 mole), C (0.01 1 mole) is subjected to 160 watt microwave radiation for 4 minutes under the catalyst of some drops of glacial acetic acid added to the medium. At the end of the reaction duration, it is controlled with TLC and the mixture is extracted three times by means of 20 ml_ CH ₂ CI ₂ and the solvent is vaporized and the solid part is crystallized in ethanol. Example 24: 8th method which can be used in preparation of the Formula III substances

I or II (0.01 mole) and C (0.01 1 mole) is subjected to 160 watt microwave radiation for 4 minutes under the catalyst of some drops of glacial acetic acid added in 15 mL ethanol. At the end of the reaction duration, the reaction is cooled down to room temperature. The mixture is filtered and it is washed with 10 mL water, and the precipitating solid part is crystallized in 2 mL ethanol and cleaned.