Title:
N-CONTAINING DERIVATIVE OF SUBSTITUTED PHENOL HYDROXY ACID ESTER, AND PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/078073
Kind Code:
A1
Abstract:
Provided are an N-containing derivative of substituted phenol hydroxy acid ester, and the preparation and use thereof. A compound is represented by formula (I). A salt of the compound of formula (I) has good water solubility, and, in vivo, can rapidly and completely release substituted phenols having a pharmacological effect, which can improve the water solubility of substituted phenols, rapidly exert the pharmacological effects of substituted phenols in vivo, and has good safety. Also disclosed are a method for preparing the above-mentioned compound and the use thereof in the preparation of drugs that produce anaesthesia and/or sedative and hypnotic effects on humans and animals.
Inventors:
YANG JUN (CN)
LIU JIN (CN)
ZHANG WEIYI (CN)
LIU JIN (CN)
ZHANG WEIYI (CN)
Application Number:
PCT/CN2020/121527
Publication Date:
April 29, 2021
Filing Date:
October 16, 2020
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07C229/08; A61K31/215; A61P23/00; A61P25/20; C07C69/017; C07D205/02; C07D207/00; C07D211/00; C07D265/28
Domestic Patent References:
| WO2006017351A1 | 2006-02-16 |
Foreign References:
| CN102381997A | 2012-03-21 | |||
| CN102617380A | 2012-08-01 |
Other References:
YANG, JUN ET AL.: "Synthesis and characterization of novel quick-release propofol prodrug via lactonization", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 18 January 2013 (2013-01-18), XP028986072, DOI: 10.1016/j.bmcl.2013.01.034
ALTOMARE C. ET AL: "Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino esters", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 20, no. 1, 1 September 2003 (2003-09-01), NL, pages 17 - 26, XP002990063, ISSN: 0928-0987, DOI: 10.1016/S0928-0987(03)00161-1
ALTOMARE C. ET AL: "Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino esters", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 20, no. 1, 1 September 2003 (2003-09-01), NL, pages 17 - 26, XP002990063, ISSN: 0928-0987, DOI: 10.1016/S0928-0987(03)00161-1
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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