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Title:
N-CONTAINING HETEROARYL DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES COMPRISING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/107919
Kind Code:
A1
Abstract:
The present invention relates to: an N-containing heteroaryl derivative; an isomer thereof; a hydrate thereof; a solvate thereof or a pharmaceutically acceptable salt thereof; a method for preparing same; and a pharmaceutical composition which is for preventing or treating protein kinase-related diseases and comprises same as an active ingredient. The N-containing heteroaryl derivative according to the present invention exhibits high inhibitory ability against various protein kinases, and thus a pharmaceutical composition containing same as an active ingredient can be effectively used for preventing or treating protein kinase-related diseases, for example, cancer, degenerative brain disease, or inflammatory disease.

Inventors:
JO SEO HYUN (KR)
KIM HYUN KYUNG (KR)
KIM SEUNG SU (KR)
CHOI HYEON JIN (KR)
MA DA HOON (KR)
RYU HEE SUN (KR)
SON JUNG BEOM (KR)
KIM SUNG HWAN (KR)
KIM NAM DOO (KR)
Application Number:
PCT/KR2020/016377
Publication Date:
May 27, 2022
Filing Date:
November 19, 2020
Export Citation:
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Assignee:
VORONOI CO LTD (KR)
VORONOIBIO INC (KR)
International Classes:
C07D471/08; A61K31/517; A61K31/519; A61P25/28; A61P29/00; A61P35/00; C07D401/14; C07D487/04; C07D491/048; C07D495/04
Domestic Patent References:
WO2007023382A22007-03-01
WO2002022607A12002-03-21
Foreign References:
KR20120089648A2012-08-13
Other References:
CRAWFORD JAMES J., LEE WENDY, ALIAGAS IGNACIO, MATHIEU SIMON, HOEFLICH KLAUS P., ZHOU WEI, WANG WEIRU, ROUGE LIONEL, MURRAY LESLEY: "Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 58, no. 12, 25 June 2015 (2015-06-25), US , pages 5121 - 5136, XP055931857, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b00572
CHENZHOU HAO, ZHAO FAN, SONG HONGYAN, GUO JING, LI XIAODONG, JIANG XIAOLIN, HUAN RAN, SONG SHUAI, ZHANG QIAOLING, WANG RUIFENG, WA: "Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 61, no. 1, 11 January 2018 (2018-01-11), US , pages 265 - 285, XP055767957, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01342
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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