Title:
N-CONTAINING HETEROCYCLIC COMPOUNDS AND THEIR USE AS 5-HT ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2001087845
Kind Code:
A3
Abstract:
A compound of the formula (I): wherein A is a hydrogen atom, an optionally substituted, unsaturated, N-containing heterocyclic group or a group of the formula (a) : wherein R is an optionally substituted aryl group or an optionally substituted heterocyclic group;M is -(CH2)n-, -(CH2)n-O-(CH2)m- or -(CH2)n-NH-(CH2)m-, wherein n and m are independently 0,1 or 2; Q is an optionally substituted cycloalkylene group, an optionally substituted arylene group or an optionally substituted divalent heterocyclic group; andthe moiety of the formula (b): is an optionally substituted, unsaturated, mono-, di-, tri- or tetra-cyclic, N-containing heterocyclic group which may contain additional hetero atom(s) selected from the group consisting of nitrogen, oxygen and sulfur atoms as the ring member(s), its prodrug or a pharmaceutically acceptable salt thereof.
Inventors:
YAMADA AKIRA (JP)
SPEARS GLEN (JP)
HAYASHIDA HISASHI (JP)
TOMISHIMA MASAKI (JP)
ITO KIYOTAKA (JP)
IMANISHI MASASHI (JP)
SPEARS GLEN (JP)
HAYASHIDA HISASHI (JP)
TOMISHIMA MASAKI (JP)
ITO KIYOTAKA (JP)
IMANISHI MASASHI (JP)
Application Number:
PCT/JP2001/004002
Publication Date:
August 29, 2002
Filing Date:
May 14, 2001
Export Citation:
Assignee:
FUJISAWA PHARMACEUTICAL CO (JP)
YAMADA AKIRA (JP)
SPEARS GLEN (JP)
HAYASHIDA HISASHI (JP)
TOMISHIMA MASAKI (JP)
ITO KIYOTAKA (JP)
IMANISHI MASASHI (JP)
YAMADA AKIRA (JP)
SPEARS GLEN (JP)
HAYASHIDA HISASHI (JP)
TOMISHIMA MASAKI (JP)
ITO KIYOTAKA (JP)
IMANISHI MASASHI (JP)
International Classes:
A61P43/00; C07D217/08; C07D237/26; C07D261/20; C07D277/60; C07D277/82; C07D401/12; C07D401/14; C07D403/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D491/04; C07D495/04; C07D498/04; C07D521/00; (IPC1-7): C07D217/22; A61K31/395; A61P43/00; C07D217/08; C07D237/26; C07D237/34; C07D261/20; C07D277/60; C07D277/82; C07D401/12; C07D401/14; C07D403/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D491/04; C07D495/04; C07D498/04
Domestic Patent References:
| WO1997012880A1 | 1997-04-10 | |||
| WO1993011106A1 | 1993-06-10 | |||
| WO1993020066A1 | 1993-10-14 | |||
| WO1999009845A1 | 1999-03-04 |
Foreign References:
| US5424431A | 1995-06-13 |
Other References:
MOLINA, PEDRO ET AL: "New methodology for the preparation of pyrrole and indole derivatives via iminophosphoranes:synthesis of pyrrolo[1,2- a]quinoxalines, indolo[3,2-c]quinolines and indolo[1,2- c]quinazolines", TETRAHEDRON (1990), 46(3), 1063-78, XP002093042
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