N-HETEROCYCLIC CARBENE CATALYST AND PREPARATION METHOD THEREFOR - SHENZHEN BAY LABORATORY PINGSHAN TRANSLATIONAL MEDICINE CENTER

Title:

N-HETEROCYCLIC CARBENE CATALYST AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2022/104599

Kind Code:

A1

Abstract:

An N-heterocyclic carbene catalyst. The structural general formula of the N-heterocyclic carbene catalyst is shown in formula I; and Ar1 and Ar2 in formula I are each independently selected from any one of aryl, substituted aryl, heteroaryl, and substituted heteroaryl. According to the N-heterocyclic carbene catalyst, introducing another active site thiourea(urea) group on the basis of an N-heterocyclic carbene skeleton can form a plurality of bifunctional thiourea(urea) N-heterocyclic carbene catalysts. The N-heterocyclic carbene catalyst has good catalytic activity in the catalysis of an asymmetric aza-Michael reaction, and therefore has potential application in the field of organic asymmetric catalysis.

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Inventors:

CHEN JIEAN (CN)
HUANG YONG (CN)
GUO FANGFANG (CN)

Application Number:

PCT/CN2020/129804

Publication Date:

May 27, 2022

Filing Date:

November 18, 2020

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Assignee:

SHENZHEN BAY LABORATORY PINGSHAN TRANSLATIONAL MEDICINE CENTER (CN)

International Classes:

C07D249/16; C07D403/00

Foreign References:

CN102757416A	2012-10-31
CN105473559A	2016-04-06

Other References:

ZHENG PINGUAN, GONDO CHENAIMWOYO A., BODE JEFFREY W.: "Late-Stage Diversification of Chiral N-Heterocyclic-Carbene Precatalysts for Enantioselective Homoenolate Additions", CHEMISTRY - AN ASIAN JOURNAL, WILEY-VCH, vol. 6, no. 2, 1 February 2011 (2011-02-01), pages 614 - 620, XP055931575, ISSN: 1861-4728, DOI: 10.1002/asia.201000617
BRAND JONATHAN, SILES JOSÉ, WASER JÉRÔME: "Synthesis of Chiral Bifunctional (Thio)Urea N-Heterocyclic Carbenes", SYNLETT, GEORG THIEME VERLAG, DE, vol. 2010, no. 06, 1 April 2010 (2010-04-01), DE , pages 881 - 884, XP055931577, ISSN: 0936-5214, DOI: 10.1055/s-0029-1219543

Attorney, Agent or Firm:

SHENZHEN ZHONGYI UNION INTELLECTUAL PROPERTY AGENCY CO.,LTD. (CN)

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