Title:
N-SUBSTITUTED OSELTAMIVIR DERIVATIVES WITH ANTIMICROBIAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2020/259471
Kind Code:
A1
Abstract:
Provided herein are oseltamivir analogs useful for the treatment and prevention of viral infections, pharmaceutical compositions comprising the same and methods preparation and use thereof.
Inventors:
MA CONG (CN)
YANG XIAO (CN)
YE JIQING (CN)
CHAN PAUL KAY-SHEUNG (CN)
CHAN WAN YI (CN)
YANG XIAO (CN)
YE JIQING (CN)
CHAN PAUL KAY-SHEUNG (CN)
CHAN WAN YI (CN)
Application Number:
PCT/CN2020/097602
Publication Date:
December 30, 2020
Filing Date:
June 23, 2020
Export Citation:
Assignee:
UNIV HONG KONG POLYTECHNIC (CN)
UNIV HONG KONG CHINESE (CN)
UNIV HONG KONG CHINESE (CN)
International Classes:
C07D207/325; A61K31/16; A61K31/185; A61K31/215; A61K31/341; A61K31/381; A61K31/41; A61K31/415; A61K31/4155; A61K31/42; A61K31/422; A61K31/4427; A61P31/16; C07C231/02; C07C233/52; C07D207/323; C07D307/38; C07D407/04; C07D409/04; C07D413/04
Foreign References:
| CN107056636A | 2017-08-18 | |||
| CN103923060A | 2014-07-16 | |||
| CN109553554A | 2019-04-02 |
Other References:
ZIMA, VĂCLAV ET AL.: "Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, 17 May 2019 (2019-05-17), pages 2935 - 2947, XP085704946, DOI: 10.1016/j.bmc.2019.05.024
YE, JIQING ET AL.: "Novel N-Substituted oseltamivir derivatives as potent influenza neuramindase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 182, 22 August 2019 (2019-08-22), pages 111635, XP085874921, DOI: 10.1016/j.ejmech.2019.111635
YE, JIQING ET AL.: "Novel N-Substituted oseltamivir derivatives as potent influenza neuramindase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 182, 22 August 2019 (2019-08-22), pages 111635, XP085874921, DOI: 10.1016/j.ejmech.2019.111635
Attorney, Agent or Firm:
BEIJING PAT SF INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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