N-TYPE CALCIUM CHANNEL BLOCKERS

Title:

N-TYPE CALCIUM CHANNEL BLOCKERS

Document Type and Number:

WIPO Patent Application WO2005070919

Kind Code:

A8

Abstract:

The present invention relates to 3-amino pyrrolidine derivatives of Formula (1) or (2) Where : X is CR<3> or N; W is L<2>-A<3> or X'(A<1>)(A<2>); A<1>, A<2>, and A<3> are 5- or 6- membered aliphatic or aromatic rings optionally containing one heteroatom selected from 0, N, and S, and optionally fused to an additional ring; L' and L<2> are C1-10 alkyl or C2-10 alkenyl, wherein C is optionally replaced by a heteroatom selected from N, 0, or S, and/or further substituted with =0; R', R<2>, and R<3> vary amongst several possible substituents; and n is 0 to 7.The present invention further relates to methods for modulating calcium channel activity. Compounds of formula (1) and (2) are useful in treating conditions associated which benefit from blocking calcium ion channels.

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Inventors:

PAJOUHESH HASSAN (CA)
PAJOUHESH HOSSEIN (CA)
DING YANBING (CA)
SNUTCH TERRANCE P (CA)

Application Number:

PCT/CA2005/000073

Publication Date:

October 20, 2005

Filing Date:

January 21, 2005

Export Citation:

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Assignee:

NEUROMED TECH INC (CA)
PAJOUHESH HASSAN (CA)
PAJOUHESH HOSSEIN (CA)
DING YANBING (CA)
SNUTCH TERRANCE P (CA)

International Classes:

A61K31/40; A61K31/4439; C07D207/14; C07D207/16; C07D207/273; C07D207/30; C07D401/06; C07D207/26; (IPC1-7): C07D401/06; A61K31/40; A61K31/4439; C07D207/14; C07D207/26

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