N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Title:

N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES, METHODS OF PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Document Type and Number:

WIPO Patent Application WO/2014/123364

Kind Code:

A1

Abstract:

The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an actice ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.

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WO/1999/029314	NOVEL SALTS OF METFORMIN AND METHOD
WO/2017/042126	METHOD FOR PRODUCING BIGUANIDE SALTS AND S-TRIAZINES

Inventors:

MIN CHANG HEE (KR)
KIM YONG EUN (KR)
OH BYUNG KYU (KR)
LEE JI SUN (KR)
HEO HYE JIN (KR)
OH JU HOON (KR)
CHO WOONG (KR)

Application Number:

PCT/KR2014/001006

Publication Date:

August 14, 2014

Filing Date:

February 06, 2014

Export Citation:

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Assignee:

HANALL BIOPHARMA CO LTD (KR)

International Classes:

C07C279/26; A61K31/155; C07C277/02

Domestic Patent References:

WO1992007560A1

1992-05-14

Foreign References:

KR20110081093A	2011-07-13
US3960949A	1976-06-01
US4080460A	1978-03-21

Other References: