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Title:
N2S2-TYPE BI-FUNCTIONAL NICOTINAMIDE CHELATING AGENTS FOR RADIOACTIVE ISOTOPES
Document Type and Number:
WIPO Patent Application WO1997010853
Kind Code:
A3
Inventors:
DINKELBORG LUDGER (DE)
HILGER CHRISTOPH STEPHAN (DE)
KRAMP WOLFGANG (DE)
PLATZEK JOHANNES (DE)
RADUECHEL BERND (DE)
Application Number:
DE9601824W
Publication Date:
August 28, 1997
Filing Date:
September 19, 1996
Export Citation:
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Assignee:
DIAGNOSTIKFORSCHUNG INST (DE)
DINKELBORG LUDGER (DE)
HILGER CHRISTOPH STEPHAN (DE)
KRAMP WOLFGANG (DE)
PLATZEK JOHANNES (DE)
RADUECHEL BERND (DE)
International Classes:
A61K51/04; A61K51/08; A61K51/10; C07D213/82; C07F13/00; C07K5/083; C07K5/103; C07K7/14; C07K14/575; (IPC1-7): A61K51/04; A61K51/08
Domestic Patent References:
WO1993015771A11993-08-19
WO1994009128A11994-04-28
WO1995019791A11995-07-27
WO1995006633A11995-03-09
WO1994000489A21994-01-06
WO1995032192A11995-11-30
Foreign References:
DE4301871A11994-07-14
EP0403243A11990-12-19
Other References:
COULAIS Y ET AL: "SYNTHESIS, CHARACTERIZATION AND BIODISTRIBUTION OF NEW 99MTC OXO AND NITRIDO COMPLEXES WITH BI- AND TETRADENDATE UNSATURATED NS AND N2S2 SCHIFF BASES DERIVED FROM 2-AMINOCYCLOPENTENE-1- DITHIOCARBOXYLIC ACID AS POTENTIAL HEART IMAGING AGENTS", NUCLEAR MEDICINE AND BIOLOGY, vol. 21, no. 2, 1 February 1994 (1994-02-01), pages 263 - 268, XP000434379
YAMAMURA T. ET AL: "Ni(II) complexes of N,N'-ethylenebis(o-mercaptobenzamide): A quadridentate thiolato amide {S2N2} ligand", BULL. CHEM. SOC. JPN., 1990, VOL. 63, NO. 4, SEITEN 999-1004, XP002034477
O'NEIL J P ET AL: "PROGESTIN RADIOPHARMACEUTICALS LABELED WITH TECHNETIUM AND RHENIUM: SYNTHESIS, BINDING AFFINITY, AND IN VIVO DISTRIBUTION OF A NEW PROGESTIN N2S2-METAL CONJUGATE", BIOCONJUGATE CHEMISTRY, vol. 5, no. 3, 1 May 1994 (1994-05-01), pages 182 - 193, XP000446095
CHI DY ET AL: "Homodimeric and heterodimeric bis(amino thiol) oxometal complexes with rhenium(V) and technetium (V). Control of heterodimeric complex formation and an approach to metal complexes that mimic steroid hormones.", J MED CHEM, APR 1 1994, VOL. 37, NO. 7, PAGES 928-37, XP002034420
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