Title:
NANOPARTICLES COMPRISING DRUG DIMERS, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/194298
Kind Code:
A1
Abstract:
The present invention relates to nanoparticles comprising drug dimers, and a use thereof. The nanoparticles comprising drug dimers, of the present invention, can increase drug content and improve the drug dispersibility. In addition, the nanoparticles have increased targeting efficiency. Therefore, an effective pharmacological effect can be obtained by using a smaller amount of a drug, and thus commercial applicability is excellent.
Inventors:
HWANG DO WON (KR)
KI YOUNG WOOK (KR)
LEE DONGWON (KR)
YOO DONGHYUCK (KR)
KI YOUNG WOOK (KR)
LEE DONGWON (KR)
YOO DONGHYUCK (KR)
Application Number:
PCT/KR2021/003765
Publication Date:
September 30, 2021
Filing Date:
March 26, 2021
Export Citation:
Assignee:
THERABEST CO LTD (KR)
INDUSTRIAL COOPERATION FOUNDATION JEONBUK NATIONAL UNIV (KR)
INDUSTRIAL COOPERATION FOUNDATION JEONBUK NATIONAL UNIV (KR)
International Classes:
A61K47/36; C07C403/24; A61K47/69; C07C69/76; C07C323/26; C07D305/14; C07D491/22; C07F5/02; C07H15/252; C07J41/00
Foreign References:
| DE4032187A1 | 1992-04-16 |
Other References:
LU LU; DU YAWEI; ISMAIL MUHAMMAD; LING LONGBING; YAO CHEN; FU ZHENGLIN; LI XINSONG: "Liposomes assembled from dimeric retinoic acid phospholipid with improved pharmacokinetic properties", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 112, 15 January 2018 (2018-01-15), NL, pages 186 - 194, XP085319902, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2017.11.017
ATASHRAZM FARZANEH, LOWENTHAL RAY M., DICKINSON JOANNE L., HOLLOWAY ADELE F., WOODS GREGORY M.: "Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo", ONCOTARGET, vol. 7, no. 29, 19 July 2016 (2016-07-19), pages 46028 - 46041, XP055853422, DOI: 10.18632/oncotarget.10016
HAN LINGFEI, HU LEJIAN, LIU FULEI, WANG XIN, HUANG XIAOXIAN, LIU BOWEN, FENG FENG, LIU WENYUAN, QU WEI: "Redox-sensitive micelles for targeted intracellular delivery and combination chemotherapy of paclitaxel and all-trans-retinoid acid", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 14, no. 5, 1 September 2019 (2019-09-01), NL, pages 531 - 542, XP055853427, ISSN: 1818-0876, DOI: 10.1016/j.ajps.2018.08.009
PEI QING, HU XIULI, ZHOU JUNLI, LIU SHI, XIE ZHIGANG: "Glutathione-responsive paclitaxel dimer nanovesicles with high drug content", BIOMATERIALS SCIENCE, vol. 5, no. 8, 1 January 2017 (2017-01-01), pages 1517 - 1521, XP055853432, ISSN: 2047-4830, DOI: 10.1039/C7BM00052A
MILENA MENOZZI ET AL., JPHARMSCI, 1 June 1984 (1984-06-01)
ATASHRAZM FARZANEH, LOWENTHAL RAY M., DICKINSON JOANNE L., HOLLOWAY ADELE F., WOODS GREGORY M.: "Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo", ONCOTARGET, vol. 7, no. 29, 19 July 2016 (2016-07-19), pages 46028 - 46041, XP055853422, DOI: 10.18632/oncotarget.10016
HAN LINGFEI, HU LEJIAN, LIU FULEI, WANG XIN, HUANG XIAOXIAN, LIU BOWEN, FENG FENG, LIU WENYUAN, QU WEI: "Redox-sensitive micelles for targeted intracellular delivery and combination chemotherapy of paclitaxel and all-trans-retinoid acid", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 14, no. 5, 1 September 2019 (2019-09-01), NL, pages 531 - 542, XP055853427, ISSN: 1818-0876, DOI: 10.1016/j.ajps.2018.08.009
PEI QING, HU XIULI, ZHOU JUNLI, LIU SHI, XIE ZHIGANG: "Glutathione-responsive paclitaxel dimer nanovesicles with high drug content", BIOMATERIALS SCIENCE, vol. 5, no. 8, 1 January 2017 (2017-01-01), pages 1517 - 1521, XP055853432, ISSN: 2047-4830, DOI: 10.1039/C7BM00052A
MILENA MENOZZI ET AL., JPHARMSCI, 1 June 1984 (1984-06-01)
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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