Title:
NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2021/012721
Kind Code:
A1
Abstract:
Disclosed in the present invention are a naphthalenesulfonamide compound, a preparation method, and an application. The naphthalenesulfonamide compound provided by the present invention can interfere with Keap1-Nrf2 binding and activate Nrf2 to relieve inflammatory damage and improve an inflammatory microenvironment, has a potential anti-inflammatory activity, and can be used for preparing an anti-inflammatory drug for inflammatory damage of various inflammation-related diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal Inflammations, rheumatoid arthritis, etc.
Inventors:
YOU QIDONG (CN)
JIANG ZHENGYU (CN)
LIU YUTING (CN)
LU MENGCHEN (CN)
SHAO HONGLI (CN)
ZHAO JING (CN)
XU XIAOLI (CN)
GUO XIAOKE (CN)
WANG LEI (CN)
JIANG ZHENGYU (CN)
LIU YUTING (CN)
LU MENGCHEN (CN)
SHAO HONGLI (CN)
ZHAO JING (CN)
XU XIAOLI (CN)
GUO XIAOKE (CN)
WANG LEI (CN)
Application Number:
PCT/CN2020/084460
Publication Date:
January 28, 2021
Filing Date:
April 13, 2020
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07C311/29; A61P1/00; A61P3/10; A61P9/10; A61P11/00; A61P13/12; A61P19/02; A61P25/16; A61P25/28; A61P29/00; A61P39/06; C07C303/40; C07D307/82
Foreign References:
| CN110256305A | 2019-09-20 | |||
| CN108101821A | 2018-06-01 | |||
| CN108752245A | 2018-11-06 | |||
| EP2998294A1 | 2016-03-23 |
Other References:
LU MENG-CHEN, ZHANG XIAN, WU FENG, TAN SHI-JIE, ZHAO JING, YOU QI-DONG, JIANG ZHENG-YU: "Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 14, 25 July 2019 (2019-07-25), US, pages 6796 - 6813, XP055774950, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00818
HANGZHOU DAVID, SCIENCE AND EDUCATION INSTRUMENT CO
HANGZHOU DAVID, SCIENCE AND EDUCATION INSTRUMENT CO
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
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