Title:
NAPHTHOQUINONE FUSED TRIAZOLE DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/232807
Kind Code:
A1
Abstract:
Provided are a naphthoquinone fused triazole derivative, preparation method and application thereof. The naphthoquinone fused triazole derivative has a structure represented by the following formula (I), wherein X is C or N; R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 are each independently any one of hydrogen, halogen, hydroxyl, cyano, sulfydryl, amino, nitro, nitroso, alkyl, alkoxy, ester group, carboxyl and sulfonyl. Also provided is the application of the naphthoquinone fused triazole derivative or a pharmaceutically acceptable salt or hydrate thereof in preparation of a medicament for treating a disease with abnormal signal transduction of STAT3.
Inventors:
LIU JIAWEI (CN)
YU QIANG (CN)
MA HONGYAN (CN)
ZHANG QING (CN)
ZENG XINLING (CN)
WEN LIANGXI (CN)
LIU JINGLI (CN)
YU QIANG (CN)
MA HONGYAN (CN)
ZHANG QING (CN)
ZENG XINLING (CN)
WEN LIANGXI (CN)
LIU JINGLI (CN)
Application Number:
PCT/CN2019/095288
Publication Date:
November 26, 2020
Filing Date:
July 09, 2019
Export Citation:
Assignee:
GUANGZHOU UNIV OF CHINESE MEDICINE GUANGZHOU ACADEMY OF CHINESE MEDICINE (CN)
International Classes:
C07D249/22; A61P35/00; C07D471/04
Domestic Patent References:
| WO2012021409A2 | 2012-02-16 | |||
| WO2009023558A1 | 2009-02-19 |
Foreign References:
| EP0033214A2 | 1981-08-05 | |||
| EP0033215A2 | 1981-08-05 | |||
| CN101854937A | 2010-10-06 |
Other References:
WU, JIAN-SUNG ET AL.: "Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2, 3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 19, 8 September 2015 (2015-09-08), XP055755260, DOI: 20200218100407X
ABU-ORABI, SULTAN T. ET AL.: "Synthesis of mono- and bis-triazoles via 1, 3-dipolar cycloaddition reactions of azide derivatives with naphtho- and benzoquinone", JORDAN JOURNAL OF CHEMISTRY, vol. 1,, no. 2,, 31 December 2006 (2006-12-31), XP055755261, DOI: 20200218100846X
ACS: "Registry-1", REGISTRY, 16 November 1984 (1984-11-16), DOI: 20200218101055X
ABU-ORABI, SULTAN T. ET AL.: "Synthesis of mono- and bis-triazoles via 1, 3-dipolar cycloaddition reactions of azide derivatives with naphtho- and benzoquinone", JORDAN JOURNAL OF CHEMISTRY, vol. 1,, no. 2,, 31 December 2006 (2006-12-31), XP055755261, DOI: 20200218100846X
ACS: "Registry-1", REGISTRY, 16 November 1984 (1984-11-16), DOI: 20200218101055X
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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