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Title:
NAPHTHYLUREA AND NAPHTHYLACETAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 (VR1) ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2003/014064
Kind Code:
A1
Abstract:
Naphthylurea and naphthylacetamide derivatives of formula (I) which have vanilloid receptor 1 (VR1) antagonistic activity are disclosed, formula (I) wherein Y represents formula (II) and formula (III) and the variables Q, X, R6, R7, R8, R8a, R9, R10 and R11 are as defined in the claims. The compounds are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.

Inventors:
YURA TAKESHI (JP)
MOGI MUNETO (JP)
IKEGAMI YUKA (JP)
MASUDA TSUTOMA (JP)
KOKUBO TOSHIO (JP)
URBAHNS KLAUS (JP)
LOWINGER TIMOTHY B (DE)
YOSHIDA NAGAHIRO (JP)
FREITAG JOACHIM (DE)
MEIER HEINRICH (DE)
WITTKA-NOPPER REILINDE (DE)
MARUMO MAKIKO (JP)
SHIROO MASAHIRO (JP)
TAJIMI MASAOMI (JP)
TAKESHITA KEISUKE (JP)
MORIWAKI TOSHIYA (JP)
TSUKIMI YASUHIRO (JP)
Application Number:
PCT/EP2002/008493
Publication Date:
February 20, 2003
Filing Date:
July 31, 2002
Export Citation:
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Assignee:
BAYER AG (DE)
YURA TAKESHI (JP)
MOGI MUNETO (JP)
IKEGAMI YUKA (JP)
MASUDA TSUTOMA (JP)
KOKUBO TOSHIO (JP)
URBAHNS KLAUS (JP)
LOWINGER TIMOTHY B (DE)
YOSHIDA NAGAHIRO (JP)
FREITAG JOACHIM (DE)
MEIER HEINRICH (DE)
WITTKA-NOPPER REILINDE (DE)
MARUMO MAKIKO (JP)
SHIROO MASAHIRO (JP)
TAJIMI MASAOMI (JP)
TAKESHITA KEISUKE (JP)
MORIWAKI TOSHIYA (JP)
TSUKIMI YASUHIRO (JP)
International Classes:
C07D295/12; A61K31/17; A61K31/18; A61K31/192; A61K31/24; A61K31/343; A61K31/357; A61K31/36; A61K31/381; A61K31/403; A61K31/4184; A61K31/42; A61K31/421; A61K31/433; A61K31/47; A61K31/505; A61K31/5375; A61P7/12; A61P9/10; A61P13/00; A61P13/10; A61P25/00; A61P25/04; A61P25/28; A61P29/00; A61P43/00; C07C235/38; C07C275/32; C07C275/34; C07C275/36; C07C275/38; C07C275/40; C07C275/42; C07C311/08; C07C311/47; C07C311/51; C07C323/42; C07C323/44; C07D209/88; C07D215/38; C07D235/10; C07D239/69; C07D261/14; C07D261/16; C07D263/10; C07D285/06; C07D295/135; C07D307/88; C07D317/66; C07D319/18; C07D333/20; C07D333/54; (IPC1-7): C07C235/38; A61K31/17; A61P13/10; C07C275/32; C07C275/34; C07C275/36; C07C275/38; C07C275/40; C07C275/42; C07C311/08; C07C311/47; C07C323/44; C07D209/88; C07D215/38; C07D235/10; C07D239/69; C07D261/14; C07D261/16; C07D263/10; C07D285/06; C07D295/135; C07D307/88; C07D317/66; C07D319/18; C07D333/20; C07D333/54
Domestic Patent References:
WO2000050387A12000-08-31
Other References:
HONMA, TERUKI ET AL: "Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: New de Novo Design Strategy and Library Design", JOURNAL OF MEDICINAL CHEMISTRY (2001), 44(26), 4615-4627, XP002220243
LECLERC, VERONIQUE ET AL: "Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands", BIOORGANIC & MEDICINAL CHEMISTRY (1998), 6(10), 1875-1887, XP002220244
ANDRIEUX, J. ET AL: "Synthesis of new naphthalene analogs of serotonin", CHIM. THERAP. (1966), (2), 57-61, XP009000513
DRAY A: "NEUROPHARMACOLOGICAL MECHANISMS OF CAPSAICIN AND RELATED SUBSTANCES", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 44, no. 4, 18 August 1992 (1992-08-18), pages 611 - 615, XP000576776, ISSN: 0006-2952
Attorney, Agent or Firm:
BAYER HEALTHCARE AG (Patents and Licensing, Leverkusen, DE)
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