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Patent Searching and Data


Title:
NEAR INFRARED PORPHYRIN COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/133816
Kind Code:
A1
Abstract:
The present invention provides a porphyrin compound and a preparation method therefor and use thereof, and a pharmaceutical composition using the porphyrin compound as an active ingredient. The porphyrin compound has a novel and adjustable structure, and can be derivatized and modified at a plurality of sites to achieve biocompatible modification and function change. The absorption wavelength of the porphyrin compound is in the near infrared region, which can achieve a deeper tissue penetration depth and has good photodynamic therapeutic activity.

Inventors:
ZHANG JUNLONG (CN)
NING YINGYING (CN)
YANG ZISHU (CN)
WANG BINGWU (CN)
Application Number:
PCT/CN2020/138669
Publication Date:
June 30, 2022
Filing Date:
December 23, 2020
Export Citation:
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Assignee:
UNIV BEIJING (CN)
International Classes:
A61K31/7056; C07D491/22
Foreign References:
CN112279862A2021-01-29
US9649625B12017-05-16
CN105622620A2016-06-01
Other References:
AKHIGBE JOSHUA, HASKOOR JOHN, KRAUSE JEANETTE A., ZELLER MATTHIAS, BRÜCKNER CHRISTIAN: "Formation, structure, and reactivity of meso-tetraaryl-chlorolactones, -porpholactams, and -chlorolactams, porphyrin and chlorin analogues incorporating oxazolone or imidazolone moieties", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 11, no. 22, 14 June 2013 (2013-06-14), pages 3616 - 3628, XP009537704, ISSN: 1477-0520, DOI: 10.1039/C3OB40138C
SAMANKUMARA LALITH P., DORAZIO SARINA J., AKHIGBE JOSHUA, LI RUOSHI, NIMTHONG-ROLDÁN ARUNPATCHA, ZELLER MATTHIAS, BRÜCKNER CHRISTI: "Indachlorins: Nonplanar Indanone-Annulated Chlorin Analogues with Panchromatic Absorption Spectra between 300 and 900 nm", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 21, no. 31, 27 July 2015 (2015-07-27), DE, pages 11118 - 11128, XP055945032, ISSN: 0947-6539, DOI: 10.1002/chem.201501230
YAO YUHANG, ET AL.: "Porpholactone Chemistry: Regioisomeric Effect of β-Substituents and Biological Applications of Rare Earth Complexes", ZHONGGUO-XITU-XUEBAO: JIKAN = JOURNAL OF THE CHINESE RARE EARTH SOCIETY, BEIJING : YEJIN GONGYE CHUBANSHE, CN, vol. 39, no. 3, 14 December 2020 (2020-12-14), CN , pages 456 - 468, XP055945033, ISSN: 1000-4343, DOI: 10.11785/S1000-4343.20210309
Attorney, Agent or Firm:
BEIJING CONCEPT INTELLECTUAL PROPERTY AGENCY (CN)
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