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Title:
NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/183809
Kind Code:
A1
Abstract:
The present invention relates to a nebivolol synthesis method and intermediate compound thereof. Specifically, the present invention relates to a method for synthesizing nebivolol, intermediate compound thereof and method for preparing the intermediate compound.

Inventors:
ZHENG ZHIGUO (CN)
Application Number:
PCT/CN2015/079329
Publication Date:
November 24, 2016
Filing Date:
May 19, 2015
Export Citation:
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Assignee:
ZHEJIANG AUSUN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D311/58; C07C41/18; C07C41/20; C07C41/22; C07C41/30; C07C43/225; C07C43/23; C07D301/14; C07D301/19; C07D303/22; C07F7/08
Foreign References:
CN104650022A2015-05-27
DE102014107132A12015-11-26
CN102858759A2013-01-02
CN102344431A2012-02-08
US20110250454A12011-10-13
CN101463024A2009-06-24
CN101541791A2009-09-23
CN103833717A2014-06-04
CN102816141A2012-12-12
CN101553485A2009-10-07
Other References:
ZHANG, QINGSHAN ET AL.: "Asymmetric Synthesis of Nebivolol Intermidiate", JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, vol. 25, no. 6, 30 June 2005 (2005-06-30), pages 546 - 550, XP009504633
BARRY M. TROST ET AL.: "Synthesis of Chiral Chromans by the Pd-Catalyzed Asymmetric Allylic Alkylation (AAA): Scope, Mechanism, and Applications", J. AM. CHEM. SOC., vol. 126, no. 38, 3 September 2004 (2004-09-03), pages 11966 - 11983, XP055330381
S. CHANDRASEKHAR ET AL.: "Enantioselective Total Synthesis of the Antihypertensive Agent (S, R,R, R)-Nebivolol", TETRAHEDRON, vol. 56, no. 34, 31 December 2000 (2000-12-31), pages 6339 - 6344, XP004214993
See also references of EP 3299364A4
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
北京市中咨律师事务所 (CN)
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