Title:
NEURAMINIC ACID DERIVATIVE, SIALIDASE ACTIVITY INHIBITOR AND ANTIINFLUENZA DRUG
Document Type and Number:
WIPO Patent Application WO/2011/081083
Kind Code:
A1
Abstract:
Provided are a neuraminic acid derivative, which selectively inhibits virus sialidase activity but little inhibits human sialidase activity, a sialidase activity inhibitor, and an antiinfluenza drug.
The aforesaid neuraminic acid derivative is characterized by comprising a compound represented by chemical formula (1), a pharmaceutically acceptable salt thereof, a hydrate of the same, a solvate of the same or a prodrug of the same.
In chemical formula (1), R1 and R2 represent hydrogen, an optionally branched C1-8 alkyl group or an optionally branched C1-8 cycloalkyl group; and R3 represents hydrogen or fluorine.
Inventors:
KISO MAKOTO (JP)
ISHIDA HIDEHARU (JP)
SADAGOPAN MAGESH (JP)
SUZUKI YASUO (JP)
MIYAGI TAEKO (JP)
ISHIDA HIDEHARU (JP)
SADAGOPAN MAGESH (JP)
SUZUKI YASUO (JP)
MIYAGI TAEKO (JP)
Application Number:
PCT/JP2010/073284
Publication Date:
July 07, 2011
Filing Date:
December 24, 2010
Export Citation:
Assignee:
UNIV GIFU (JP)
CHUBU UNIVERSITY (JP)
KISO MAKOTO (JP)
ISHIDA HIDEHARU (JP)
SADAGOPAN MAGESH (JP)
SUZUKI YASUO (JP)
MIYAGI TAEKO (JP)
CHUBU UNIVERSITY (JP)
KISO MAKOTO (JP)
ISHIDA HIDEHARU (JP)
SADAGOPAN MAGESH (JP)
SUZUKI YASUO (JP)
MIYAGI TAEKO (JP)
International Classes:
C07D309/28; A61K31/351; A61P31/16; A61P43/00
Domestic Patent References:
| WO1991016320A1 | 1991-10-31 | |||
| WO2010093706A2 | 2010-08-19 |
Foreign References:
| JP2002012555A | 2002-01-15 |
Other References:
MAGESH, S. ET AL.: "Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: Selective inhibitors of lysosomal sialidase (NEU1)", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, 2008, pages 532 - 537, XP022424699, DOI: doi:10.1016/j.bmcl.2007.11.084
Attorney, Agent or Firm:
AOYAMA, Yo (JP)
Aoyama Sun (JP)
Aoyama Sun (JP)
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