NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

Title:

NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2015/010054

Kind Code:

A3

Abstract:

Described herein are neuroactive steroids of the Formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

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Inventors:

MARTINEZ BOTELLA GABRIEL (US)
HARRISON BOYD L (US)
ROBICHAUD ALBERT JEAN (US)
SALITURO FRANCESCO GERALD (US)

Application Number:

PCT/US2014/047246

Publication Date:

April 09, 2015

Filing Date:

July 18, 2014

Export Citation:

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Assignee:

SAGE THERAPEUTICS INC (US)

International Classes:

A61K31/56; A61P25/00; C07J3/00

Domestic Patent References:

WO1994027608A1	1994-12-08
WO2012116290A2	2012-08-30

Other References: