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Title:
NEW AMPHOTERICIN ANALOGOUS COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO/2012/085784
Kind Code:
A3
Abstract:
The present invention relates to polyene macrolide derivatives according to the formula (I): wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.

Inventors:
ANTILLON DIAZ ARMANDO (MX)
CARRILLO TRIPP MAURICIO (MX)
FERNANDEZ ZERTUCHE MARIO (MX)
FLORES ROMERO JOSE DAVID (MX)
JIMENEZ MONTEJO FABIOLA ELOISA (MX)
LEON BUITIMEA ANGEL (MX)
MORALES NAVA ROSMARBEL (MX)
OCAMPO MARTINEZ LILIA (MX)
ORTEGA BLAKE IVAN (MX)
REYES ESPARZA JORGE ALBERTO (MX)
RODRIGUEZ FRAGOSO MARIA DE LOURDES (MX)
SANTIAGO ANGELINO TANIA MINERVA (MX)
VARGAS GONZALEZ MARIA CRISTINA (MX)
Application Number:
PCT/IB2011/055721
Publication Date:
November 22, 2012
Filing Date:
December 16, 2011
Export Citation:
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Assignee:
CT INVESTIG Y ESTUDIOS DEL IPN (MX)
UNIV AUTONOMA DEL ESTADO DE MORELOS (MX)
UNIV MEXICO NACIONAL AUTONOMA (MX)
ANTILLON DIAZ ARMANDO (MX)
CARRILLO TRIPP MAURICIO (MX)
FERNANDEZ ZERTUCHE MARIO (MX)
FLORES ROMERO JOSE DAVID (MX)
JIMENEZ MONTEJO FABIOLA ELOISA (MX)
LEON BUITIMEA ANGEL (MX)
MORALES NAVA ROSMARBEL (MX)
OCAMPO MARTINEZ LILIA (MX)
ORTEGA BLAKE IVAN (MX)
REYES ESPARZA JORGE ALBERTO (MX)
RODRIGUEZ FRAGOSO MARIA DE LOURDES (MX)
SANTIAGO ANGELINO TANIA MINERVA (MX)
VARGAS GONZALEZ MARIA CRISTINA (MX)
International Classes:
C07H17/08
Domestic Patent References:
WO1991009047A11991-06-27
WO2001091758A12001-12-06
Foreign References:
EP0489308A11992-06-10
EP0434943A11991-07-03
US4041232A1977-08-09
US4783527A1988-11-08
GB2055812A1981-03-11
Other References:
BRUZZESE T ET AL: "Amide derivatives of partricin A with potent antifungal activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 31, no. 12, 1 January 1996 (1996-01-01), pages 965 - 972, XP004071791, ISSN: 0223-5234, DOI: 10.1016/S0223-5234(97)86175-2
Attorney, Agent or Firm:
CARREÑO SÁNCHEZ, Luis Antonio (2508 Col. San Pedro Zacatenco, Edificio,Administrativo, 3er. piso, Subdirección de,Vinculación Tecnológica,Méxic, D.F. ., MX)
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