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Title:
NEW APPROACH FOR SYNTHESIZING ACETYL COENZYME A AND DERIVATIVE PRODUCT THEREOF USING GLYCOLALDEHYDE
Document Type and Number:
WIPO Patent Application WO/2018/107880
Kind Code:
A1
Abstract:
Disclosed is a new approach for synthesizing an acetyl coenzyme A and a derivative product thereof (5-phosphoarabinose, acetyl phosphoric acid, acetyl phosphate, and an acetyl coenzyme A derivative compound) using glycolaldehyde. The approach comprises a reaction of glycolaldehyde and 3-phosphoglyceraldehyde under the catalysis of an enzyme to generate 5-phosphoarabinose, wherein the enzyme is selected from an aldolase, a transaldolase, an isoenzyme and a mutant enzyme thereof.

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Inventors:
MA HONGWU (CN)
YANG XUE (CN)
YUAN QIANQIAN (CN)
JIANG HUIFENG (CN)
Application Number:
PCT/CN2017/105664
Publication Date:
June 21, 2018
Filing Date:
October 11, 2017
Export Citation:
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Assignee:
TIANJIN INST IND BIOTECHNOLOGY CAS (CN)
International Classes:
C12P19/02; C12P7/04; C12P9/00; C12P19/32
Domestic Patent References:
WO2015181074A12015-12-03
WO2015144447A12015-10-01
Foreign References:
CN106755172A2017-05-31
Other References:
YIN, XIN ET AL.: "Preparation of Acetylphosphate Dilithium and its Assay", CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS, vol. 24, no. 9, 30 September 2003 (2003-09-30), pages 198 - 199
Attorney, Agent or Firm:
BEIJING BRIGHT IP AGENCY CO., LTD. (CN)
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