NEW CRYSTAL FORM OF CEFATHIAMIDINE COMPOUND AND PREPARATION METHOD THEREFOR

Title:

NEW CRYSTAL FORM OF CEFATHIAMIDINE COMPOUND AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2016/107331

Kind Code:

A1

Abstract:

A new crystal form of a Cefathiamidine compound and a preparation method therefor. The method comprises: dissolving a Cefathiamidine compound with the purity greater than or equal to 98% in a solvent selected from methanol and the like to form a solution with the concentration of 0.05 g/mL to 0.2 g/mL, and dropwise adding in the solution a solvating-out agent selected from n-propyl alcohol and the like; cooling the solution to 0°C to 10°C at a cooling speed of 0.2°C/min to 1°C/min; and continuing to stir for 1 to 3 h, separating the obtained solid-liquid suspension, and drying to obtain the new crystal form product.

Inventors:

HAO HONGXUN (CN)
TAO LINGGANG (CN)
SUN ZHIHONG (CN)
HOU BAOHONG (CN)
LV JUN (CN)
YIN QIUXIANG (CN)
WANG YONGLI (CN)
GONG JUNBO (CN)
XIE CHUANG (CN)
BAO YING (CN)

Application Number:

PCT/CN2015/095233

Publication Date:

July 07, 2016

Filing Date:

November 20, 2015

Export Citation:

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Assignee:

UNIV TIANJIN (CN)
HAINAN LINGKANG PHARMACEUTICAL (CN)

International Classes:

C07D501/12; C07D501/28

Foreign References:

CN104530083A	2015-04-22
CN1495187A	2004-05-12
CN1462751A	2003-12-24
CN103012434A	2013-04-03

Other References:

LIU, SHUYU ET AL.: "Studies on Preparation and Stability of Polymorphs of Cefathiamidine", CHINESE JOURNAL OF ANTIBIOTICS, vol. 35, no. 10, 31 October 2010 (2010-10-31), pages 760 - 762

Attorney, Agent or Firm:

BEIJING CONCEPT INTELLECTUAL PROPERTY AGENCY (CN)
北京康思博达知识产权代理事务所（普通合伙） (CN)

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