Title:
NEW DIAMINE COMPOUND AND BRAIN PROTECTING AGENT CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/1992/002487
Kind Code:
A1
Abstract:
Diamine compounds represented by general formula (I) and acid addition salts thereof, and a brain protecting agent containing the same, wherein R1 to R6 may be the same or different from one another and each represents hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyloxy, lower alkylsulfonyloxy or amino, among which the lower alkyl and lower alkoxy may be each substituted by halogen or phenyl; R7 and R8 may be the same or different from each other and each represents lower alkyl, or they may be combined together to form alkylene having 1 to 4 carbon atoms; A and A' may be the same or different from each other and each represents a single bond, -O-, -NH-, -NHCO->, -CONH->, -NHCOO->, -NHCONH-, -SONH2-> or -COS->, wherein symbol "->" represents a bond to Y or Y'; and Y and Y' may be the same or different from each other and each represents lower alkylene or lower alkenylene. They have an excellent activity of protecting the brain, are highly safe, and can exhibit potent activities by oral administration. Medicines containing them are effecting in treating or preventing the progress of cerebral dysfunctions accompanying cerebral hemorrhage, cerebral infarction, subarachnoid hemorrhage, transient cerebral ischemic attack, or cerebrovascular diseases.
Inventors:
SATO SEIICHI (JP)
KAWAMURA KIYOSHI (JP)
TAKAHASHI YOSIO (JP)
WATANABE KOICHIRO (JP)
SHIMIZU SADAHIRO (JP)
OHTA TOMIO (JP)
KAWAMURA KIYOSHI (JP)
TAKAHASHI YOSIO (JP)
WATANABE KOICHIRO (JP)
SHIMIZU SADAHIRO (JP)
OHTA TOMIO (JP)
Application Number:
PCT/JP1990/000970
Publication Date:
February 20, 1992
Filing Date:
July 30, 1990
Export Citation:
Assignee:
KOWA CO (JP)
International Classes:
A61K31/165; A61K31/18; A61K31/195; A61K31/22; A61K31/24; A61K31/245; A61K31/25; A61K31/255; A61K31/27; A61K31/135; A61K31/4164; A61K31/495; A61K31/55; A61K31/551; A61P25/28; C07C211/09; C07C211/27; C07C211/28; C07C211/29; C07C211/49; C07C235/50; C07C237/04; C07C271/28; C07C275/28; C07C275/34; C07C309/65; C07C311/18; C07C311/29; C07C311/41; C07C327/26; C07C327/28; C07C327/30; C07C327/32; C07C327/34; C07C327/36; C07D243/08; C07D295/04; C07D295/06; C07D295/08; C07D295/12; C07D295/13; C07D295/14; (IPC1-7): A61K31/25; A61K31/27; A61K31/495; C07C211/27; C07C271/28; C07C309/65; C07C327/36; C07D243/08
Foreign References:
JPS60181058A | 1985-09-14 | |||
JPS6075469A | 1985-04-27 | |||
JPS5732255A | 1982-02-20 |
Other References:
See also references of EP 0541798A4
Download PDF:
Previous Patent: PROCESSES FOR PREPARING SECONDARY AND TERTIARY AMINES
Next Patent: PROPYLAMINE DERIVATIVES
Next Patent: PROPYLAMINE DERIVATIVES