Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NEW SACCHARIDE MIMICS AND THEIR USE AS INHIBITORS OF ANGIOGENESIS AND METASTASIS FORMATION
Document Type and Number:
WIPO Patent Application WO/2012/093091
Kind Code:
A3
Abstract:
The present invention relates to saccharide mimics which show a better biological activity at low concentrations as known saccharide mimics in inhibiting angiogenesis and inhibiting formation of metastasis by inhibiting adhesion and/or migration of human cancer cells, particularly in concentrations lower than 5 mM, and to pharmaceutical compositions comprising these saccharide mimics. The compounds of the present invention are useful as mimics of cell surface structures and, thus, for influencing cell-cell and cell-extracellular (ECM) interactions, which are controlled by bonds between protein-protein, saccharide-saccharide or saccharide-lectin on the cell - surface. Exemplary compounds are: formulae (I), (II), (III), (IV).

Inventors:
SCHWARTZ-ALBIEZ REINHARD (DE)
MARANO GRAZIA (DE)
FREI EVA (DE)
FRANK MARTIN (DE)
MEISTER BETINA (DE)
Application Number:
PCT/EP2012/000040
Publication Date:
October 11, 2012
Filing Date:
January 05, 2012
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
DEUTSCHES KREBSFORSCH (DE)
SCHWARTZ-ALBIEZ REINHARD (DE)
MARANO GRAZIA (DE)
FREI EVA (DE)
FRANK MARTIN (DE)
MEISTER BETINA (DE)
International Classes:
C07H15/26; A61K31/7048; A61P35/04
Foreign References:
US20040059101A12004-03-25
Other References:
GRONEWOLD, CLAAS: "Synthetic saccharide mimetics interfere with different steps of the metastatic cascade of malignant melanoma cells in vitro", 22 March 2005 (2005-03-22), XP002626866, Retrieved from the Internet [retrieved on 20110304]
Attorney, Agent or Firm:
SCH√úSSLER, Andrea (Truderingerstr. 246, M√ľnchen, DE)
Download PDF: