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Title:
NEW USE FOR NPR-A AGONIST
Document Type and Number:
WIPO Patent Application WO/2017/082186
Kind Code:
A1
Abstract:
A drug combining (A) a natriuretic peptide receptor GC-A agonist, with, as (B) an anti-malignant tumor agent, a compound having anti-microtubule action, or a PD-1 pathway inhibitor [(B')]. By administering the drug at least 5 days before administering the (B) anti-malignant tumor agent, the natriuretic peptide receptor GC-A agonist effect is exhibited, and the (B) anti-malignant tumor agent can effectively reach the inside of the tumor cells via the bloodstream, thereby making the drug useful as an anti-malignant tumor treatment drug having a strong effect.

Inventors:
KANGAWA KENJI
NOJIRI TAKASHI
HOSODA HIROSHI
Application Number:
PCT/JP2016/082919
Publication Date:
May 18, 2017
Filing Date:
November 07, 2016
Export Citation:
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Assignee:
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
SHIONOGI & CO (JP)
International Classes:
A61K45/06; A61K31/337; A61K38/22; A61K45/00; A61P35/00; A61P43/00; C07K14/47; C07K14/58
Domestic Patent References:
WO2012118042A12012-09-07
Foreign References:
Other References:
AKITAKA MAKIYAMA ET AL.: "Aratana Kotai Chiryo no Tenkai Aratani Kaihatsu sareta Kotai Chiryo Igan", MOLECULAR TARGETED THERAPY FOR CANCER, vol. 13, no. 2, 24 July 2015 (2015-07-24), pages 194 - 202, ISSN: 1347-6955
KENJIRO NAMIKAWA: "Tokushu . Hifu Akusei Shuyo Akusei Kokushokushu ni Taisuru Bunshi Hyoteki Chiryo", THE JOURNAL OF MEDICINE, vol. 72, no. 2, 27 January 2015 (2015-01-27), pages 247 - 254, ISSN: 0389-3898
YOSHIHIKO TOMITA: "Tokushu Hinyokigan ni Taisuru Men'eki Ryoho no Genjo to Shin Tenkai Shinki Men'eki Ryoho (Immune checkpoint inhibitor) -Jin Saibogan o Chushin ni", JAPANESE JOURNAL OF UROLOGICAL SURGERY, vol. 28, no. 7, 15 July 2015 (2015-07-15), pages 1157 - 1163, ISSN: 0914-6180
BALIGA,R.S. ET AL.: "Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis", BR. J. PHARMACOL., vol. 171, no. 14, July 2014 (2014-07-01), pages 3463 - 3475, XP055384130, ISSN: 1476-5381
SHINSUKE MURAKAMI ET AL.: "POS116 C Type Natriuretic Peptide wa Koensho Sayo, Kosen'ika Sayo ni yori Mouse Hai Sen'isho o Keigen saseru", THE JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY, vol. 43, 10 April 2005 (2005-04-10), pages 150, ISSN: 1343-3490
Attorney, Agent or Firm:
HOSODA, YOSHINORI (JP)
Yoshinori Hosoda (JP)
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