Title:
NICOTINAMIDE MONONUCLEOTIDE INTERMEDIATE AND METHOD FOR SYNTHESIZING NICOTINAMIDE MONONUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2021/092919
Kind Code:
A1
Abstract:
Disclosed are a nicotinamide mononucleotide intermediate and a method for synthesizing nicotinamide mononucleotide, and the present invention belongs to the field of chemical synthesis. Provided is a method for synthesizing a nicotinamide mononucleotide intermediate as represented by formula III, wherein the nicotinamide mononucleotide intermediate is obtained by reacting compounds I and II under the action of a Lewis acid. Further provided is a method for preparing nicotinamide mononucleotide, the method involving: first synthesizing nicotinamide mononucleotide intermediate III, then removing a protection group, and then performing phosphorylation. The synthesis method has the advantages of a high stereoselectivity, a low cost and being environmentally friendly.
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Inventors:
WEI XIAWEI (CN)
WEI YUQUAN (CN)
YELLA RAMESH (CN)
ZHOU ZHENGYANG (CN)
DUPATI GAUTAM (CN)
MORTHALA RAO RAGHAVENDAR (CN)
SENANAYEKE HUGH CHRIS (CN)
GUO PENG (CN)
WEI YUQUAN (CN)
YELLA RAMESH (CN)
ZHOU ZHENGYANG (CN)
DUPATI GAUTAM (CN)
MORTHALA RAO RAGHAVENDAR (CN)
SENANAYEKE HUGH CHRIS (CN)
GUO PENG (CN)
Application Number:
PCT/CN2019/118852
Publication Date:
May 20, 2021
Filing Date:
November 15, 2019
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07H19/048; C07H1/00
Domestic Patent References:
| WO2018089830A1 | 2018-05-17 | |||
| WO2019122084A1 | 2019-06-27 |
Foreign References:
| CN109053838A | 2018-12-21 |
Other References:
MAKAROV M. V., HARRIS N. W., RODRIGUES M., MIGAUD M. E.: "Scalable syntheses of traceable ribosylated NAD + precursors", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 17, no. 38, 2 October 2019 (2019-10-02), pages 8716 - 8720, XP055812690, ISSN: 1477-0520, DOI: 10.1039/C9OB01981B
LEE JAEMOON ET AL.: "A chemical synthesis of nicotinamide adenine dinucleotide(NAD+)", CHEM. COMMUN., no. 8, 31 December 1999 (1999-12-31), XP055103548, DOI: 10.1039/a809930h
FRANCHETTI, P. ; PASQUALINI, M. ; PETRELLI, R. ; RICCIUTELLI, M. ; VITA, P. ; CAPPELLACCI, L.: "Stereoselective synthesis of nicotinamide beta-riboside and nucleoside analogs", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 14, no. 18, 20 September 2004 (2004-09-20), Amsterdam , NL, pages 4655 - 4658, XP027347993, ISSN: 0960-894X
MIKHAIL V MAKAROV, MIGAUD M E: "Syntheses and chemical properties of ò-nicotinamide riboside and its analogues and derivatives", BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, BIOMED CENTRAL, LONDON, GB, vol. 15, 13 February 2019 (2019-02-13), GB, pages 401 - 430, XP055638913, ISSN: 1860-5397, DOI: 10.3762/bjoc.15.36
LEE JAEMOON ET AL.: "A chemical synthesis of nicotinamide adenine dinucleotide(NAD+)", CHEM. COMMUN., no. 8, 31 December 1999 (1999-12-31), XP055103548, DOI: 10.1039/a809930h
FRANCHETTI, P. ; PASQUALINI, M. ; PETRELLI, R. ; RICCIUTELLI, M. ; VITA, P. ; CAPPELLACCI, L.: "Stereoselective synthesis of nicotinamide beta-riboside and nucleoside analogs", BIORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 14, no. 18, 20 September 2004 (2004-09-20), Amsterdam , NL, pages 4655 - 4658, XP027347993, ISSN: 0960-894X
MIKHAIL V MAKAROV, MIGAUD M E: "Syntheses and chemical properties of ò-nicotinamide riboside and its analogues and derivatives", BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, BIOMED CENTRAL, LONDON, GB, vol. 15, 13 February 2019 (2019-02-13), GB, pages 401 - 430, XP055638913, ISSN: 1860-5397, DOI: 10.3762/bjoc.15.36
Attorney, Agent or Firm:
CHENGDU HONGQIAO PATENT LAW OFFICE (CN)
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