NITRIC OXIDE RELEASING NAPROXEN

Title:

NITRIC OXIDE RELEASING NAPROXEN

Document Type and Number:

WIPO Patent Application WO/2011/012400

Kind Code:

A3

Abstract:

The invention relates to a nitric oxide releasing naproxen derivative of formula (I) and its use for the treatment of diseases associated with pain and inflammation. This NO releasing naproxen derivative shows a surprisingly improved gastrointestinal safety and possesses cardio-protective benefits.

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Inventors:

BIONDI STEFANO (IT)
BASTIA ELENA (IT)
RONSIN GAEL (IT)

Application Number:

PCT/EP2010/059364

Publication Date:

June 23, 2011

Filing Date:

July 01, 2010

Export Citation:

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Assignee:

NICOX SA (FR)
BIONDI STEFANO (IT)
BASTIA ELENA (IT)
RONSIN GAEL (IT)

International Classes:

C07C203/04; A61K31/21; A61K31/216; A61P29/00

Domestic Patent References:

WO2004004648A2	2004-01-15
WO2005070874A1	2005-08-04

Other References:

ELLIS, J.L. ET AL.: "NMI-1182, a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor", INFLAMMOPHARMACOLOGY, vol. 12, no. 5-6, 2005, pages 521 - 534, XP002631997

Attorney, Agent or Firm:

BARCHIELLI, Giovanna (Via L. Ariosto 21, Bresso, IT)

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