Title:
NITROGEN-CONTAINING HETEROCYCLIC 5-HT3 RECEPTOR MODULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/110052
Kind Code:
A1
Abstract:
A nitrogen-containing heterocyclic 5-HT3 receptor modulator, a preparation method therefor and use thereof, relating to the field of medicinal chemistry. The nitrogen-containing heterocyclic 5-HT3 receptor modulator is a compound as represented by formula I, or a salt thereof, or a stereoisomer thereof, or a tautomer thereof, or a prodrug thereof, or a solvate thereof, or a hydrate thereof. Experiments prove that the prepared compound has a strong affinity for 5-HT3 receptor, has high activity as a 5-HT3 receptor modulator, can be used for preparing the 5-HT3 receptor modulator, and can also be used for preparing a medicament for treating diseases (such as irritable bowel syndrome, nausea, vomiting, gastroenteritis, gastric dysfunction, diarrhea, pain, carcinoid syndrome, and drug addiction) related to the 5-HT3 receptor, and thus has a good application prospect.
Inventors:
XIE DEJIAN (CN)
CHEN FANG (CN)
LI XIAOXIA (CN)
LIU JIACHUAN (CN)
ZHANG WEI (CN)
HUANG JINKUN (CN)
CHEN FANG (CN)
LI XIAOXIA (CN)
LIU JIACHUAN (CN)
ZHANG WEI (CN)
HUANG JINKUN (CN)
Application Number:
PCT/CN2020/132398
Publication Date:
June 02, 2022
Filing Date:
November 27, 2020
Export Citation:
Assignee:
SCIMOUNT BIOTECHNOLOGY SHENZHEN CO LTD (CN)
International Classes:
A61K31/55; C07D471/16; A61K45/06; A61P1/00; A61P3/04; A61P11/06; A61P17/10; A61P25/00; A61P25/16; A61P25/22; A61P25/30; A61P25/32; C07D519/00
Foreign References:
| CN112390799A | 2021-02-23 | |||
| CN102459267A | 2012-05-16 | |||
| CN111825702A | 2020-10-27 | |||
| CN102046176A | 2011-05-04 | |||
| CN111217818A | 2020-06-02 | |||
| CN111662299A | 2020-09-15 |
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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