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Title:
NITROGEN-CONTAINING POLYCYCLIC FUSED RING COMPOUNDS, AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/023209
Kind Code:
A1
Abstract:
The present invention relates to the field of medicinal chemistry, and relates in particular to nitrogen-containing polycyclic fused ring compounds represented by formula I, and a pharmaceutical composition thereof, a preparation method therefor and an application thereof. The compounds of the present invention may be used as highly selective and very effective RET inhibitors. The described class of compounds have strong inhibitory effects on RET gate-keeper residue mutant RET V804M mutation, RET solvent front residue mutant RET G810R and other clinically relevant RET mutants and RET wt. The compounds may also significantly inhibit the growth of TT cell lines originating from thyroid cancer and Ba/F3 cells transformed by various RET mutants, and may significantly induce the death of TT cells.

Inventors:
ZHONG JUN (CN)
LIU YONGBO (CN)
LIU LIBIN (CN)
CHEN XIAOHU (CN)
WANG HAO (CN)
LU YING (CN)
Application Number:
PCT/CN2020/107049
Publication Date:
February 11, 2021
Filing Date:
August 05, 2020
Export Citation:
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Assignee:
APPLIED PHARMACEUTICAL SCIENCE INC (CN)
International Classes:
C07D519/00; A61K31/444; A61P35/00
Domestic Patent References:
WO2017011776A12017-01-19
WO2020064009A12020-04-02
Foreign References:
US10112942B22018-10-30
US8426437B22013-04-23
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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