NON-AROMATIC DIFLUORO ANALOGUES OF RESORCYLIC ACID LACTONES

Title:

NON-AROMATIC DIFLUORO ANALOGUES OF RESORCYLIC ACID LACTONES

Document Type and Number:

WIPO Patent Application WO/2016/196256

Kind Code:

A3

Abstract:

This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro analogues of resorcylic acid lactones, and methods of treatment comprising non-aromatic difluoro analogues of resorcylic acid lactones.

Inventors:

PEARCE CEDRIC (US)
CROATT MITCHELL P (US)
FAKHOURI LARA (US)
OBERLIES NICHOLAS H (US)

Application Number:

PCT/US2016/034562

Publication Date:

June 01, 2017

Filing Date:

May 27, 2016

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Assignee:

UNIV OF NORTH CAROLINA AT GREENSBORO (US)
PEARCE CEDRIC (US)

International Classes:

C07D313/00; A61K31/335; A61K31/336; C07D493/04

Domestic Patent References:

WO2006036941A2	2006-04-06
WO2008021213A1	2008-02-21

Other References:

NINOMIYA-TSUJI, J. ET AL.: "A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 20, 2003, pages 48485 - 18490, XP055385204
HILDEBRAND, A. ET AL.: "Aromatic hydroxylation and catechol formation: a novel metabolic pathway of the growth promotor zeranol'' , Toxicology letters", vol. 192, no. 3, pages 379 - 386, XP026885874
FAKHOURI, L. ET AL.: "Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, no. 21, pages 6993 - 6999, XP029298995

Attorney, Agent or Firm:

KIM, Julia (US)

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