Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NON-HUMAN MODEL OF GESTATIONAL AND ADULT FOLATE DEFICIENCY AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002024868
Kind Code:
A3
Abstract:
Disclosed is a genetically modified non-human animal that is a model for defective folate transport. Specifically the non-human animal comprises a genetic modification that results in decreased or absent expression and/or biological activity of the endogenous reduced folate carrier. The animal can be further modified by introduction into the genome of a nucleid acid molecule encoding the human reduced folate carrier. Such an animal can be used in methods to identify compounds useful for treating a variety of conditions associated with defective folate transport, or for the identification of anti-folate compounds useful for treating cancer. The animal can also be used to study the biochemical and molecular events associated with folate transport. Compounds identified using such a model are valuable for therapeutic treatments.

Inventors:
PATTERSON DAVID
BRENNAN MILES B
HOCHGESCHWENDER UTE
FLINTOFF WAYNE F
SADLISH HEATHER
UNDERHILL T MICHAEL
WILLIAMS FREDERICK M R
Application Number:
PCT/US2001/029966
Publication Date:
October 10, 2002
Filing Date:
September 24, 2001
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ELEANOR ROOSEVELT INST (US)
OKLAHOMA MED RES FOUND (US)
UNIV WESTERN ONTARIO (CA)
International Classes:
C07K14/705; C12N15/85; G01N33/50; (IPC1-7): A01K67/00; A01K67/027; G01N33/00
Foreign References:
US5763216A1998-06-09
Other References:
WONG ET AL.: "Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective chinese hamster overy cells", J. BIOL. CHEM., vol. 270, no. 29, 21 July 1995 (1995-07-21), pages 17468 - 17475, XP000601568
Download PDF: