Title:
NON-VIRAL IMMUNO-TARGETING
Document Type and Number:
WIPO Patent Application WO/2021/007453
Kind Code:
A3
Abstract:
The disclosure provides compositions and methods for delivering a payload to cells or tissues that express GLUT4. In some embodiments, the compositions comprise an antibody, or fragment or derivative thereof, that specifically binds to glucose transporter 4 ("GLUT4") protein, and a therapeutic payload conjugated thereto. In some exemplary embodiments, the compositions are useful for methods of treating a disease or condition in a subject with a genetic mutation in a gene encoding dystrophin protein, wherein the payload comprises a nucleic acid encoding a functional dystrophin protein or functional fragment thereof to ameliorate aspects of the disease.
Inventors:
FROEHNER STANLEY C (US)
WHITEHEAD NICHOLAS P (US)
WHITEHEAD NICHOLAS P (US)
Application Number:
PCT/US2020/041441
Publication Date:
April 08, 2021
Filing Date:
July 09, 2020
Export Citation:
Assignee:
UNIV WASHINGTON (US)
International Classes:
A61K8/14; C07K14/28; A61K39/395; A61P21/00; C07H21/00
Foreign References:
| US20050170509A1 | 2005-08-04 | |||
| US20170196833A1 | 2017-07-13 | |||
| US20080249052A1 | 2008-10-09 |
Other References:
TUCKER ET AL.: "Isolation of state-dependent monoclonal antibodies against the 12- transmembrane domain glucose transporter 4 using virus-like particles", PROC. NAT. ACAD. SCI., vol. 115, no. 22, 29 May 2018 (2018-05-29), pages E4990 - E4999, XP055806882, DOI: 10.1073/pnas.1716788115
DEAS ET AL.: "In vivo-targeted gene delivery using antibody-based nonviral vector", HUM GENE THER, vol. 13, no. 9, 10 June 2002 (2002-06-10), pages 1101 - 1114, XP002449008, DOI: 10.1089/104303402753812502
DATABASE UniProt [online] 1 April 1990 (1990-04-01), "GLUT4_HUMAN", XP055811568, retrieved from UniProt Database accession no. P14672
MANN ET AL.: "Differences in DNA condensation and release by lysine and arginine homopeptides govern their DNA delivery efficiencies", MOL PHARM., vol. 8, no. 5, 3 October 2011 (2011-10-03), pages 1729 - 1741, XP055110957, DOI: 10.1021/mp2000814
DEAS ET AL.: "In vivo-targeted gene delivery using antibody-based nonviral vector", HUM GENE THER, vol. 13, no. 9, 10 June 2002 (2002-06-10), pages 1101 - 1114, XP002449008, DOI: 10.1089/104303402753812502
DATABASE UniProt [online] 1 April 1990 (1990-04-01), "GLUT4_HUMAN", XP055811568, retrieved from UniProt Database accession no. P14672
MANN ET AL.: "Differences in DNA condensation and release by lysine and arginine homopeptides govern their DNA delivery efficiencies", MOL PHARM., vol. 8, no. 5, 3 October 2011 (2011-10-03), pages 1729 - 1741, XP055110957, DOI: 10.1021/mp2000814
Attorney, Agent or Firm:
NOWAK, Thomas S. (US)
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